| Title : Development of a multivalent acetylcholinesterase inhibitor via dynamic combinatorial chemistry - Xu_2020_Int.J.Biol.Macromol_150_1184 |
| Author(s) : Xu J , Zhao S , Zhang S , Pei J , Li Y , Zhang Y , He X , Hu L |
| Ref : Int J Biol Macromol , 150 :1184 , 2020 |
|
Abstract :
In this study, we report the generation of a polymer based dynamic combinatorial library (DCL) using aldehyde-functionalized linear poly(glycidol) and hydrazide derivatives as initial building blocks. In combination with tetrameric acetylcholinesterase (AChE), a certain type of amplified acylhydrazone side chain is identified and further used for the synthesis of a multivalent AChE inhibitor. The cytotoxicity and inhibition properties of the multivalent inhibitor are evaluated, and the results indicate superior bioactivity compared to the commercial reference Edrophonium chloride. |
| PubMedSearch : Xu_2020_Int.J.Biol.Macromol_150_1184 |
| PubMedID: 31758986 |
Xu J, Zhao S, Zhang S, Pei J, Li Y, Zhang Y, He X, Hu L (2020)
Development of a multivalent acetylcholinesterase inhibitor via dynamic combinatorial chemistry
Int J Biol Macromol
150 :1184
Xu J, Zhao S, Zhang S, Pei J, Li Y, Zhang Y, He X, Hu L (2020)
Int J Biol Macromol
150 :1184