Title : Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children - Yamakawa-Kobayashi_2003_Hum.Genet_113_311 |
Author(s) : Yamakawa-Kobayashi K , Yanagi H , Endo K , Arinami T , Hamaguchi H |
Ref : Hum Genet , 113 :311 , 2003 |
Abstract :
Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels. |
PubMedSearch : Yamakawa-Kobayashi_2003_Hum.Genet_113_311 |
PubMedID: 12884003 |
Gene_locus related to this paper: human-LIPG |
Gene_locus | human-LIPG |
Yamakawa-Kobayashi K, Yanagi H, Endo K, Arinami T, Hamaguchi H (2003)
Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
Hum Genet
113 :311
Yamakawa-Kobayashi K, Yanagi H, Endo K, Arinami T, Hamaguchi H (2003)
Hum Genet
113 :311