human-LIPG

Homo sapiens (Human) endothelial lipase LIPG_HUMAN flj43354

Comment

Endothelial lipase is a phospholipase and triglyceride lipase (predominantly phospholipase). Endothelial lipase regulates the circulating level of high density lipoprotein cholesterol (HDL-C) (the phospholipid-enriched high-density lipoprotein (HDL) is its preferred substrate). LIPG is expressed in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary, but is not detected in heart, brain and muscle. It can also form a molecular bridge between endothelial cells and lipoproteins or circulating macrophages through interaction with heparan sulfate proteoglycans. This nonenzymatic action can increase cellular lipoprotein uptake and monocyte adhesion and contribute to atherosclerosis. Endothelial lipase (EL\/LIPG) is a hallmark of Triple-negative breast cancer TNBC. LIPG is associated with long non-coding RNA DANCR whu=ich maintains extression in TNBC

Relationship

Family : Lipoprotein_Lipase

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Sequence

Peptide

MSNSVPLLCF WSLCYCFAAG SPVPFGPEGR LEDKLHKPKA TQTEVKPSVR FNLRTSKDPE HEGCYLSVGH SQPLEDCSFN MTAKTFFIIH GWTMSGIFEN WLHKLVSALH TREKDANVVV VDWLPLAHQL YTDAVNNTRV VGHSIARMLD WLQEKDDFSL GNVHLIGYSL GAHVAGYAGN FVKGTVGRIT GLDPAGPMFE GADIHKRLSP DDADFVDVLH TYTRSFGLSI GIQMPVGHID IYPNGGDFQP GCGLNDVLGS IAYGTITEVV KCEHERAVHL FVDSLVNQDK PSFAFQCTDS NRFKKGICLS CRKNRCNSIG YNAKKMRNKR NSKMYLKTRA GMPFRVYHYQ MKIHVFSYKN MGEIEPTFYV TLYGTNADSQ TLPLEIVERI EQNATNTFLV YTEEDLGDLL KIQLTWEGAS QSWYNLWKEF RSYLSQPRNP GRELNIRRIR VKSGETQRKL TFCTEDPENT SISPGRELWF RKCRDGWRMK NETSPTVELP

References (75)

Title : Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins - Sylvers-Davie_2024_Sci.Rep_14_4246
Author(s) : Sylvers-Davie KL , Bierstedt KC , Schnieders MJ , Davies BSJ
Ref : Sci Rep , 14 :4246 , 2024
PubMedID: 38379026
Gene_locus related to this paper: human-LIPG

Title : Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins - Sylvers-Davie_2023_bioRxiv__
Author(s) : Sylvers-Davie KL , Bierstedt KC , Schnieders MJ , Davies BSJ
Ref : Biorxiv , : , 2023
PubMedID: 37693454
Gene_locus related to this paper: human-LIPG

Title : Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients - Klobucar_2023_Int.J.Mol.Sci_24_2073
Author(s) : Klobucar I , Stadler JT , Klobucar L , Lechleitner M , Trbusic M , Pregartner G , Berghold A , Habisch H , Madl T , Marsche G , Frank S , Degoricija V
Ref : Int J Mol Sci , 24 :2073 , 2023
PubMedID: 36768410
Gene_locus related to this paper: human-LIPG

Title : Functional involvement of endothelial lipase in hepatitis B virus infection - Shirasaki_2023_Hepatol.Commun_7_e0206
Author(s) : Shirasaki T , Murai K , Ishida A , Kuroki K , Kawaguchi K , Wang Y , Yamanaka S , Yasukawa R , Kawasaki N , Li YY , Shimakami T , Sumiyadorj A , Nio K , Sugimoto S , Orita N , Takayama H , Okada H , Thi Bich PD , Iwabuchi S , Hashimoto S , Ide M , Tabata N , Ito S , Matsushima K , Yanagawa H , Yamashita T , Kaneko S , Honda M
Ref : Hepatol Commun , 7 :e0206 , 2023
PubMedID: 37655967
Gene_locus related to this paper: human-LIPG

Title : Mechanistic analysis of endothelial lipase G promotion of the occurrence and development of cervical carcinoma by activating the phosphatidylinositol-4,5-bisphosphate 3-kinase\/protein kinase B\/mechanistic target of rapamycin kinase signalling pathway - Huang_2023_J.Obstet.Gynaecol_43_2151353
Author(s) : Huang J , Liu R , Zhang Y , Sheng X
Ref : J Obstet Gynaecol , 43 :2151353 , 2023
PubMedID: 36606668
Gene_locus related to this paper: human-LIPG

Title : Plasma HDL pattern, cholesterol efflux and cholesterol loading capacity of serum in carriers of a novel missense variant (Gly176Trp) of endothelial lipase - Pisciotta_2022_J.Clin.Lipidol_S1933-2874_00235
Author(s) : Pisciotta L , Ossoli A , Ronca A , Garuti A , Fresa R , Favari E , Calabresi L , Calandra S , Bertolini S
Ref : J Clin Lipidol , : , 2022
PubMedID: 36002365
Gene_locus related to this paper: human-LIPG

Title : LIPG is a novel prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma - Wang_2022_J.Clin.Lab.Anal__e24824
Author(s) : Wang S , Chen Z , Lv H , Wang C , Wei H , Yu J
Ref : J Clin Lab Anal , :e24824 , 2022
PubMedID: 36572999
Gene_locus related to this paper: human-LIPG

Title : A Proof-of-Concept Inhibitor of Endothelial Lipase Suppresses Triple-Negative Breast Cancer Cells by Hijacking the Mitochondrial Function - Yang_2022_Cancers.(Basel)_14_3763
Author(s) : Yang R , Han S , Clayton J , Haghighatian M , Tsai CC , Yao Y , Li P , Shen J , Zhou Q
Ref : Cancers (Basel) , 14 :3763 , 2022
PubMedID: 35954428
Gene_locus related to this paper: human-LIPG

Title : Sphingosine-1-phosphate: metabolism, transport, atheroprotection and effect of statin treatment - Therond_2022_Curr.Opin.Lipidol_33_199
Author(s) : Therond P , Chapman MJ
Ref : Curr Opin Lipidol , 33 :199 , 2022
PubMedID: 35695616
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins - Khetarpal_2021_PLoS.Genet_17_e1009802
Author(s) : Khetarpal SA , Vitali C , Levin MG , Klarin D , Park J , Pampana A , Millar JS , Kuwano T , Sugasini D , Subbaiah PV , Billheimer JT , Natarajan P , Rader DJ
Ref : PLoS Genet , 17 :e1009802 , 2021
PubMedID: 34543263
Gene_locus related to this paper: mouse-Lipg , human-LIPG

Title : LIPG endothelial lipase and breast cancer risk by subtypes - Gago-Dominguez_2021_Sci.Rep_11_10436
Author(s) : Gago-Dominguez M , Redondo CM , Calaza M , Matabuena M , Bermudez MA , Perez-Fernandez R , Torres-Espanol M , Carracedo A , Castelao JE
Ref : Sci Rep , 11 :10436 , 2021
PubMedID: 34001944
Gene_locus related to this paper: human-LIPG

Title : LIPG: an inflammation and cancer modulator - Hong_2021_Cancer.Gene.Ther_28_27
Author(s) : Hong C , Deng R , Wang P , Lu X , Zhao X , Wang X , Cai R , Lin J
Ref : Cancer Gene Therapy , 28 :27 , 2021
PubMedID: 32572177
Gene_locus related to this paper: human-LIPG

Title : Significant association between the endothelial lipase gene 584C\/T polymorphism and coronary artery disease risk - Wu_2020_Biosci.Rep_40_
Author(s) : Wu YE , Ma L , Zhang H , Chen XR , Xu XY , Hu ZP
Ref : Bioscience Reports , 40 : , 2020
PubMedID: 32893849
Gene_locus related to this paper: human-LIPG

Title : LIPG SNPs, their haplotypes and gene-environment interactions on serum lipid levels - Yang_2019_Lipids.Health.Dis_18_10
Author(s) : Yang S , Yin RX , Miao L , Zhou YG , Wu J , Zhang QH
Ref : Lipids Health Dis , 18 :10 , 2019
PubMedID: 30621702
Gene_locus related to this paper: human-LIPG

Title : Benzothiazole-based compounds as potent endothelial lipase inhibitors - Meng_2019_Bioorg.Med.Chem.Lett__126673
Author(s) : Meng W , Adam LP , Behnia K , Zhao L , Yang R , Kopcho LM , Locke GA , Taylor DS , Yin X , Wexler RR , Finlay H
Ref : Bioorganic & Medicinal Chemistry Lett , :126673 , 2019
PubMedID: 31519373
Gene_locus related to this paper: human-LIPG

Title : Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase - Kim_2019_Bioorg.Med.Chem.Lett_29_1918
Author(s) : Kim SH , Johnson JA , Jiang J , Parkhurst B , Phillips M , Pi Z , Qiao JX , Tora G , Ye Chen A , Liu E , Yin X , Yang R , Zhao L , Taylor DS , Basso M , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Adam LP , Gordon D , Wexler RR , Finlay HJ
Ref : Bioorganic & Medicinal Chemistry Lett , 29 :1918 , 2019
PubMedID: 31176700
Gene_locus related to this paper: human-LIPG

Title : LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer - Lo_2018_Elife_7_e31334
Author(s) : Lo PK , Yao Y , Lee JS , Zhang Y , Huang W , Kane MA , Zhou Q
Ref : Elife , 7 : , 2018
PubMedID: 29350614
Gene_locus related to this paper: human-LIPG

Title : PK\/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor - Hangeland_2018_ACS.Med.Chem.Lett_9_673
Author(s) : Hangeland JJ , Abell LM , Adam LP , Jiang J , Friends TJ , Haque LE , Neels J , Onorato JM , Chen AYA , Taylor DS , Yin X , Harrity TW , Basso MD , Yang R , Sleph PG , Gordon DA , Huang CS , Wexler RR , Finlay HJ , Lawrence RM
Ref : ACS Med Chem Lett , 9 :673 , 2018
PubMedID: 30034599
Gene_locus related to this paper: human-LIPG

Title : Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase - Johnson_2018_ACS.Med.Chem.Lett_9_1263
Author(s) : Johnson JA , Tora G , Pi Z , Phillips M , Yin X , Yang R , Zhao L , Chen AY , Taylor DS , Basso M , Rose A , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Galella M , Adam LP , Gordon D , Wexler RR , Finlay HJ
Ref : ACS Med Chem Lett , 9 :1263 , 2018
PubMedID: 30613337
Gene_locus related to this paper: human-LIPG

Title : Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits - Wang_2017_Arterioscler.Thromb.Vasc.Biol_37_1282
Author(s) : Wang C , Nishijima K , Kitajima S , Niimi M , Yan H , Chen Y , Ning B , Matsuhisa F , Liu E , Zhang J , Chen YE , Fan J
Ref : Arterioscler Thromb Vasc Biol , 37 :1282 , 2017
PubMedID: 28546217
Gene_locus related to this paper: human-LIPG

Title : Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms - Amin_2017_Mol.Psychiatry_22_537
Author(s) : Amin N , Jovanova O , Adams HH , Dehghan A , Kavousi M , Vernooij MW , Peeters RP , de Vrij FM , van der Lee SJ , van Rooij JG , van Leeuwen EM , Chaker L , Demirkan A , Hofman A , Brouwer RW , Kraaij R , Willems van Dijk K , Hankemeier T , van Ijcken WF , Uitterlinden AG , Niessen WJ , Franco OH , Kushner SA , Ikram MA , Tiemeier H , van Duijn CM
Ref : Mol Psychiatry , 22 :537 , 2017
PubMedID: 27431295
Gene_locus related to this paper: human-LIPG

Title : FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth - Slebe_2016_Nat.Commun_7_11199
Author(s) : Slebe F , Rojo F , Vinaixa M , Garcia-Rocha M , Testoni G , Guiu M , Planet E , Samino S , Arenas EJ , Beltran A , Rovira A , Lluch A , Salvatella X , Yanes O , Albanell J , Guinovart JJ , Gomis RR
Ref : Nat Commun , 7 :11199 , 2016
PubMedID: 27045898
Gene_locus related to this paper: human-LIPG

Title : Association of endothelial lipase gene-384A\/C with coronary artery disease in Han Chinese people - Xie_2015_BMJ.Open_5_e007621
Author(s) : Xie L , Sun Y , Tong Y , Liu Y , Deng Y
Ref : BMJ Open , 5 :e007621 , 2015
PubMedID: 26124511
Gene_locus related to this paper: human-LIPG

Title : Investigation of the Association Between 584C\/T Polymorphism of EL Gene and Risk of Premature Coronary Artery Disease in Fars Province - Toosi_2015_J.Cardiovasc.Thorac.Res_7_118
Author(s) : Toosi S , Senemar S , Ahmadi Z , Radmanesh S
Ref : J Cardiovasc Thorac Res , 7 :118 , 2015
PubMedID: 26430500
Gene_locus related to this paper: human-LIPG

Title : The associations between endothelial lipase 584C\/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis - Cai_2014_Lipids.Health.Dis_13_85
Author(s) : Cai G , Huang Z , Zhang B , Weng W , Shi G
Ref : Lipids Health Dis , 13 :85 , 2014
PubMedID: 24886585
Gene_locus related to this paper: human-LIPG

Title : Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins - Yang_2014_Lipids_49_987
Author(s) : Yang P , Belikova NA , Billheimer J , Rader DJ , Hill JS , Subbaiah PV
Ref : Lipids , 49 :987 , 2014
PubMedID: 25167836
Gene_locus related to this paper: human-LIPG

Title : Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population - Cai_2014_Genet.Mol.Res_13_1059
Author(s) : Cai GJ , He GP , Huang ZY , Qi CP
Ref : Genet Mol Res , 13 :1059 , 2014
PubMedID: 24634127
Gene_locus related to this paper: human-LIPG

Title : Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity - Miksztowicz_2014_Arterioscler.Thromb.Vasc.Biol_34_669
Author(s) : Miksztowicz V , Schreier L , McCoy M , Lucero D , Fassio E , Billheimer J , Rader DJ , Berg G
Ref : Arterioscler Thromb Vasc Biol , 34 :669 , 2014
PubMedID: 24458708
Gene_locus related to this paper: human-LIPC , human-LPL , human-LIPG

Title : Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species - Yang_2014_Lipids_49_505
Author(s) : Yang Y , Kuwano T , Lagor WR , Albert CJ , Brenton S , Rader DJ , Ford DA , Brown RJ
Ref : Lipids , 49 :505 , 2014
PubMedID: 24777581
Gene_locus related to this paper: human-LIPC , human-LIPG

Title : Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways - Essaji_2013_Lipids_48_769
Author(s) : Essaji Y , Yang Y , Albert CJ , Ford DA , Brown RJ
Ref : Lipids , 48 :769 , 2013
PubMedID: 23794138
Gene_locus related to this paper: human-LIPG

Title : Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics - Larach_2013_Clin.Lipidol_8_635
Author(s) : Larach DB , Cuchel M , Rader DJ
Ref : Clin Lipidol , 8 :635 , 2013
PubMedID: 25374625
Gene_locus related to this paper: human-LIPG

Title : Genetic and structure-function studies of missense mutations in human endothelial lipase - Razzaghi_2013_PLoS.One_8_e55716
Author(s) : Razzaghi H , Tempczyk-Russell A , Haubold K , Santorico SA , Shokati T , Christians U , Churchill ME
Ref : PLoS ONE , 8 :e55716 , 2013
PubMedID: 23536757
Gene_locus related to this paper: human-LIPG

Title : Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice - Sun_2013_Bioorg.Med.Chem_21_7724
Author(s) : Sun S , Dean R , Jia Q , Zenova A , Zhong J , Grayson C , Xie C , Lindgren A , Samra P , Sojo L , van Heek M , Lin L , Percival D , Fu JM , Winther MD , Zhang Z
Ref : Bioorganic & Medicinal Chemistry , 21 :7724 , 2013
PubMedID: 24211162
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium - Tatematsu_2013_Arterioscler.Thromb.Vasc.Biol_33_1788
Author(s) : Tatematsu S , Francis SA , Natarajan P , Rader DJ , Saghatelian A , Brown JD , Michel T , Plutzky J
Ref : Arterioscler Thromb Vasc Biol , 33 :1788 , 2013
PubMedID: 23723371
Gene_locus related to this paper: human-LIPG

Title : The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development - Dalan_2013_Mol.Biol.Rep_40_5143
Author(s) : Dalan AB , Toptas B , Bugra Z , Polat N , Yilmaz-Aydogan H , Cimen A , Isbir T
Ref : Mol Biol Rep , 40 :5143 , 2013
PubMedID: 23673478
Gene_locus related to this paper: human-LIPG

Title : Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels - Razzaghi_2012_Front.Genet_3_89
Author(s) : Razzaghi H , Santorico SA , Kamboh MI
Ref : Front Genet , 3 :89 , 2012
PubMedID: 22723803
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes - Connelly_2012_J.Histochem.Cytochem_60_694
Author(s) : Connelly MA , D'Andrea MR , Qi J , Dzordzorme KC , Damiano BP
Ref : Journal of Histochemistry & Cytochemistry , 60 :694 , 2012
PubMedID: 22740344
Gene_locus related to this paper: human-LIPG

Title : Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients - Durlach_2011_Diabetes.Metab_37_64
Author(s) : Durlach V , Durlach A , Movesayan I , Socquard E , Zellner C , Clavel C , Nazeyrollas P , Malloy MJ , Pullinger CR , Kane JP , Ducasse A , Aouizerat BE
Ref : Diabetes Metab , 37 :64 , 2011
PubMedID: 21145773
Gene_locus related to this paper: human-LIPG

Title : Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol - Edmondson_2011_Circ.Cardiovasc.Genet_4_145
Author(s) : Edmondson AC , Braund PS , Stylianou IM , Khera AV , Nelson CP , Wolfe ML , Derohannessian SL , Keating BJ , Qu L , He J , Tobin MD , Tomaszewski M , Baumert J , Klopp N , Doring A , Thorand B , Li M , Reilly MP , Koenig W , Samani NJ , Rader DJ
Ref : Circ Cardiovasc Genet , 4 :145 , 2011
PubMedID: 21303902
Gene_locus related to this paper: human-LIPG

Title : Interactions of the LIPG 584C>T polymorphism and alcohol consumption on serum lipid levels - Liu_2011_Alcohol_45_681
Author(s) : Liu WY , Yin RX , Zhang L , Wu DF , Htet Aung LH , Hu XJ , Cao XL , Miao L
Ref : Alcohol , 45 :681 , 2011
PubMedID: 21816559
Gene_locus related to this paper: human-LIPG

Title : Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol - Khetarpal_2011_PLoS.Genet_7_e1002393
Author(s) : Khetarpal SA , Edmondson AC , Raghavan A , Neeli H , Jin W , Badellino KO , Demissie S , Manning AK , Derohannessian SL , Wolfe ML , Cupples LA , Li M , Kathiresan S , Rader DJ
Ref : PLoS Genet , 7 :e1002393 , 2011
PubMedID: 22174694
Gene_locus related to this paper: human-LIPG

Title : A novel fluorogenic substrate for the measurement of endothelial lipase activity - Darrow_2011_J.Lipid.Res_52_374
Author(s) : Darrow AL , Olson MW , Xin H , Burke SL , Smith C , Schalk-Hihi C , Williams R , Bayoumy SS , Deckman IC , Todd MJ , Damiano BP , Connelly MA
Ref : J Lipid Res , 52 :374 , 2011
PubMedID: 21062953
Gene_locus related to this paper: human-LIPG

Title : Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport - Annema_2011_Curr.Atheroscler.Rep_13_257
Author(s) : Annema W , Tietge UJ
Ref : Curr Atheroscler Rep , 13 :257 , 2011
PubMedID: 21424685
Gene_locus related to this paper: human-LIPC , human-LIPG

Title : Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT - Vergeer_2010_Atherosclerosis_211_558
Author(s) : Vergeer M , Cohn DM , Boekholdt SM , Sandhu MS , Prins HM , Ricketts SL , Wareham NJ , Kastelein JJ , Khaw KT , Kamphuisen PW , Dallinga-Thie GM
Ref : Atherosclerosis , 211 :558 , 2010
PubMedID: 20466371
Gene_locus related to this paper: human-LIPG

Title : Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo - Kojima_2010_Cardiovasc.Res_87_385
Author(s) : Kojima Y , Ishida T , Sun L , Yasuda T , Toh R , Rikitake Y , Fukuda A , Kume N , Koshiyama H , Taniguchi A , Hirata K
Ref : Cardiovascular Research , 87 :385 , 2010
PubMedID: 20045866
Gene_locus related to this paper: human-LIPG

Title : Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins - Brown_2010_Circ.Res_107_357
Author(s) : Brown RJ , Lagor WR , Sankaranaravanan S , Yasuda T , Quertermous T , Rothblat GH , Rader DJ
Ref : Circulation Research , 107 :357 , 2010
PubMedID: 20558822
Gene_locus related to this paper: human-LIPC , human-LIPG

Title : A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis - Brown_2009_J.Lipid.Res_50_1910
Author(s) : Brown RJ , Edmondson AC , Griffon N , Hill TB , Fuki IV , Badellino KO , Li M , Wolfe ML , Reilly MP , Rader DJ
Ref : J Lipid Res , 50 :1910 , 2009
PubMedID: 19411705
Gene_locus related to this paper: human-LIPG

Title : Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - Smith_2009_Atherosclerosis_206_500
Author(s) : Smith CE , Arnett DK , Tsai MY , Lai CQ , Parnell LD , Shen J , Laclaustra M , Junyent M , Ordovas JM
Ref : Atherosclerosis , 206 :500 , 2009
PubMedID: 19380136
Gene_locus related to this paper: human-LIPG

Title : Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors - Goodman_2009_Bioorg.Med.Chem.Lett_19_27
Author(s) : Goodman KB , Bury MJ , Cheung M , Cichy-Knight MA , Dowdell SE , Dunn AK , Lee D , Lieby JA , Moore ML , Scherzer DA , Sha D , Suarez DP , Murphy DJ , Harpel MR , Manas ES , McNulty DE , Annan RS , Matico RE , Schwartz BK , Trill JJ , Sweitzer TD , Wang DY , Keller PM , Krawiec JA , Jaye MC
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :27 , 2009
PubMedID: 19058966
Gene_locus related to this paper: human-LIPG

Title : Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans - Edmondson_2009_J.Clin.Invest_119_1042
Author(s) : Edmondson AC , Brown RJ , Kathiresan S , Cupples LA , Demissie S , Manning AK , Jensen MK , Rimm EB , Wang J , Rodrigues A , Bamba V , Khetarpal SA , Wolfe ML , Derohannessian S , Li M , Reilly MP , Aberle J , Evans D , Hegele RA , Rader DJ
Ref : J Clinical Investigation , 119 :1042 , 2009
PubMedID: 19287092
Gene_locus related to this paper: human-LIPG

Title : The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations - Jensen_2009_Eur.Heart.J_30_1584
Author(s) : Jensen MK , Rimm EB , Mukamal KJ , Edmondson AC , Rader DJ , Vogel U , Tjonneland A , Sorensen TI , Schmidt EB , Overvad K
Ref : Eur Heart J , 30 :1584 , 2009
PubMedID: 19411665
Gene_locus related to this paper: human-LIPG

Title : Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia - Tanaka_2009_J.Atheroscler.Thromb_16_327
Author(s) : Tanaka H , Ishida T , Johnston TP , Yasuda T , Ueyama T , Kojima Y , Kundu RK , Quertermous T , Ishikawa Y , Hirata K
Ref : J Atheroscler Thromb , 16 :327 , 2009
PubMedID: 19672025
Gene_locus related to this paper: human-LIPG

Title : A high-throughput screen for endothelial lipase using HDL as substrate - Keller_2008_J.Biomol.Screen_13_468
Author(s) : Keller PM , Rust T , Murphy DJ , Matico R , Trill JJ , Krawiec JA , Jurewicz A , Jaye M , Harpel M , Thrall S , Schwartz B
Ref : J Biomol Screen , 13 :468 , 2008
PubMedID: 18566479
Gene_locus related to this paper: human-LIPG

Title : Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population - Tang_2008_J.Lipid.Res_49_369
Author(s) : Tang NP , Wang LS , Yang L , Zhou B , Gu HJ , Sun QM , Cong RH , Zhu HJ , Wang B
Ref : J Lipid Res , 49 :369 , 2008
PubMedID: 17986713
Gene_locus related to this paper: human-LIPG

Title : Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase - Shimamura_2007_Arterioscler.Thromb.Vasc.Biol_27_366
Author(s) : Shimamura M , Matsuda M , Yasumo H , Okazaki M , Fujimoto K , Kono K , Shimizugawa T , Ando Y , Koishi R , Kohama T , Sakai N , Kotani K , Komuro R , Ishida T , Hirata K , Yamashita S , Furukawa H , Shimomura I
Ref : Arterioscler Thromb Vasc Biol , 27 :366 , 2007
PubMedID: 17110602
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels - Shimizu_2007_Circ.J_71_842
Author(s) : Shimizu M , Kanazawa K , Hirata K , Ishida T , Hiraoka E , Matsuda Y , Iwai C , Miyamoto Y , Hashimoto M , Kajiya T , Akita H , Yokoyama M
Ref : Circ J , 71 :842 , 2007
PubMedID: 17526978
Gene_locus related to this paper: human-LIPG

Title : Fluorogenic substrates for high-throughput measurements of endothelial lipase activity - Mitnaul_2007_J.Lipid.Res_48_472
Author(s) : Mitnaul LJ , Tian J , Burton C , Lam MH , Zhu Y , Olson SH , Schneeweis JE , Zuck P , Pandit S , Anderson M , Maletic MM , Waddell ST , Wright SD , Sparrow CP , Lund EG
Ref : J Lipid Res , 48 :472 , 2007
PubMedID: 17090660
Gene_locus related to this paper: human-LIPG

Title : Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues - Chen_2007_Biochim.Biophys.Acta_1771_1319
Author(s) : Chen S , Subbaiah PV
Ref : Biochimica & Biophysica Acta , 1771 :1319 , 2007
PubMedID: 17905648
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase: its role in cardiovascular disease - Paradis_2006_Can.J.Cardiol_22 Suppl B_31B
Author(s) : Paradis ME , Lamarche B
Ref : Can J Cardiol , 22 Suppl B :31B , 2006
PubMedID: 16498510
Gene_locus related to this paper: human-LIPG

Title : Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans - Hutter_2006_Atherosclerosis_185_78
Author(s) : Hutter CM , Austin MA , Farin FM , Viernes HM , Edwards KL , Leonetti DL , McNeely MJ , Fujimoto WY
Ref : Atherosclerosis , 185 :78 , 2006
PubMedID: 16023652
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine - Gauster_2005_J.Lipid.Res_46_1517
Author(s) : Gauster M , Rechberger G , Sovic A , Horl G , Steyrer E , Sattler W , Frank S
Ref : J Lipid Res , 46 :1517 , 2005
PubMedID: 15834125
Gene_locus related to this paper: human-LIPG

Title : Long-chain polyunsaturated fatty acids, endothelial lipase and atherosclerosis - Das_2005_Prostaglandins.Leukot.Essent.Fatty.Acids_72_173
Author(s) : Das UN
Ref : Prostaglandins Leukot Essent Fatty Acids , 72 :173 , 2005
PubMedID: 15664301
Gene_locus related to this paper: human-LIPG

Title : Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels - Mank-Seymour_2004_Biochim.Biophys.Acta_1636_40
Author(s) : Mank-Seymour AR , Durham KL , Thompson JF , Seymour AB , Milos PM
Ref : Biochimica & Biophysica Acta , 1636 :40 , 2004
PubMedID: 14984737
Gene_locus related to this paper: human-LIPG

Title : Structural basis of endothelial lipase tropism for HDL - Broedl_2004_FASEB.J_18_1891
Author(s) : Broedl UC , Jin W , Fuki IV , Glick JM , Rader DJ
Ref : FASEB Journal , 18 :1891 , 2004
PubMedID: 15456739
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase and cholesterol metabolism - Cilingiroglu_2004_Curr.Atheroscler.Rep_6_126
Author(s) : Cilingiroglu M , Ballantyne C
Ref : Curr Atheroscler Rep , 6 :126 , 2004
PubMedID: 15023297
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation - Broedl_2004_Trends.Cardiovasc.Med_14_202
Author(s) : Broedl UC , Jin W , Rader DJ
Ref : Trends Cardiovasc Med , 14 :202 , 2004
PubMedID: 15261893
Gene_locus related to this paper: human-LIPG

Title : Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids - Duong_2003_Biochemistry_42_13778
Author(s) : Duong M , Psaltis M , Rader DJ , Marchadier D , Barter PJ , Rye KA
Ref : Biochemistry , 42 :13778 , 2003
PubMedID: 14622025
Gene_locus related to this paper: human-LIPC , human-LIPG

Title : Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children - Yamakawa-Kobayashi_2003_Hum.Genet_113_311
Author(s) : Yamakawa-Kobayashi K , Yanagi H , Endo K , Arinami T , Hamaguchi H
Ref : Hum Genet , 113 :311 , 2003
PubMedID: 12884003
Gene_locus related to this paper: human-LIPG

Title : Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism - Ma_2003_Proc.Natl.Acad.Sci.U.S.A_100_2748
Author(s) : Ma K , Cilingiroglu M , Otvos JD , Ballantyne CM , Marian AJ , Chan L
Ref : Proc Natl Acad Sci U S A , 100 :2748 , 2003
PubMedID: 12601178
Gene_locus related to this paper: human-LIPG

Title : The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women - Paradis_2003_J.Lipid.Res_44_1902
Author(s) : Paradis ME , Couture P , Bosse Y , Despres JP , Perusse L , Bouchard C , Vohl MC , Lamarche B
Ref : J Lipid Res , 44 :1902 , 2003
PubMedID: 12867537
Gene_locus related to this paper: human-LIPG

Title : Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway - Fuki_2003_J.Biol.Chem_278_34331
Author(s) : Fuki IV , Blanchard N , Jin W , Marchadier DH , Millar JS , Glick JM , Rader DJ
Ref : Journal of Biological Chemistry , 278 :34331 , 2003
PubMedID: 12810721
Gene_locus related to this paper: human-LIPG

Title : Characterization of the lipolytic activity of endothelial lipase - McCoy_2002_J.Lipid.Res_43_921
Author(s) : McCoy MG , Sun GS , Marchadier D , Maugeais C , Glick JM , Rader DJ
Ref : J Lipid Res , 43 :921 , 2002
PubMedID: 12032167
Gene_locus related to this paper: human-LIPG

Title : Cloning of a unique lipase from endothelial cells extends the lipase gene family. -
Author(s) : Hirata K , Dichek HL , Cioffi JA , Choi SY , Leeper NJ , Quintana L , Kronmal GS , Cooper AD , Quertermous T
Ref : Journal of Biological Chemistry , 274 :14170 , 1999
PubMedID: 10318835
Gene_locus related to this paper: human-LIPG , mouse-Lipg

Title : A novel endothelial-derived lipase that modulates HDL metabolism - Jaye_1999_Nat.Genet_21_424
Author(s) : Jaye M , Lynch KJ , Krawiec J , Marchadier D , Maugeais C , Doan K , South V , Amin D , Perrone M , Rader DJ
Ref : Nat Genet , 21 :424 , 1999
PubMedID: 10192396
Gene_locus related to this paper: human-LIPG