Homo sapiens (Human) endothelial lipase LIPG_HUMAN flj43354
Endothelial lipase is a phospholipase and triglyceride lipase (predominantly phospholipase). Endothelial lipase regulates the circulating level of high density lipoprotein cholesterol (HDL-C) (the phospholipid-enriched high-density lipoprotein (HDL) is its preferred substrate). LIPG is expressed in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary, but is not detected in heart, brain and muscle. It can also form a molecular bridge between endothelial cells and lipoproteins or circulating macrophages through interaction with heparan sulfate proteoglycans. This nonenzymatic action can increase cellular lipoprotein uptake and monocyte adhesion and contribute to atherosclerosis. Endothelial lipase (EL\/LIPG) is a hallmark of Triple-negative breast cancer TNBC. LIPG is associated with long non-coding RNA DANCR whu=ich maintains extression in TNBC
Family : Lipoprotein_Lipase
Block : L
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMSNSVPLLCF WSLCYCFAAG SPVPFGPEGR LEDKLHKPKA TQTEVKPSVR FNLRTSKDPE HEGCYLSVGH SQPLEDCSFN MTAKTFFIIH GWTMSGIFEN WLHKLVSALH TREKDANVVV VDWLPLAHQL YTDAVNNTRV VGHSIARMLD WLQEKDDFSL GNVHLIGYSL GAHVAGYAGN FVKGTVGRIT GLDPAGPMFE GADIHKRLSP DDADFVDVLH TYTRSFGLSI GIQMPVGHID IYPNGGDFQP GCGLNDVLGS IAYGTITEVV KCEHERAVHL FVDSLVNQDK PSFAFQCTDS NRFKKGICLS CRKNRCNSIG YNAKKMRNKR NSKMYLKTRA GMPFRVYHYQ MKIHVFSYKN MGEIEPTFYV TLYGTNADSQ TLPLEIVERI EQNATNTFLV YTEEDLGDLL KIQLTWEGAS QSWYNLWKEF RSYLSQPRNP GRELNIRRIR VKSGETQRKL TFCTEDPENT SISPGRELWF RKCRDGWRMK NETSPTVELP
| Title : Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins - Sylvers-Davie_2024_Sci.Rep_14_4246 |
| Author(s) : Sylvers-Davie KL , Bierstedt KC , Schnieders MJ , Davies BSJ |
| Ref : Sci Rep , 14 :4246 , 2024 |
| Abstract : |
| PubMedSearch : Sylvers-Davie_2024_Sci.Rep_14_4246 |
| PubMedID: 38379026 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins - Sylvers-Davie_2023_bioRxiv__ |
| Author(s) : Sylvers-Davie KL , Bierstedt KC , Schnieders MJ , Davies BSJ |
| Ref : Biorxiv , : , 2023 |
| Abstract : |
| PubMedSearch : Sylvers-Davie_2023_bioRxiv__ |
| PubMedID: 37693454 |
| Gene_locus related to this paper: human-LIPG |
| Title : Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients - Klobucar_2023_Int.J.Mol.Sci_24_2073 |
| Author(s) : Klobucar I , Stadler JT , Klobucar L , Lechleitner M , Trbusic M , Pregartner G , Berghold A , Habisch H , Madl T , Marsche G , Frank S , Degoricija V |
| Ref : Int J Mol Sci , 24 :2073 , 2023 |
| Abstract : |
| PubMedSearch : Klobucar_2023_Int.J.Mol.Sci_24_2073 |
| PubMedID: 36768410 |
| Gene_locus related to this paper: human-LIPG |
| Title : Functional involvement of endothelial lipase in hepatitis B virus infection - Shirasaki_2023_Hepatol.Commun_7_e0206 |
| Author(s) : Shirasaki T , Murai K , Ishida A , Kuroki K , Kawaguchi K , Wang Y , Yamanaka S , Yasukawa R , Kawasaki N , Li YY , Shimakami T , Sumiyadorj A , Nio K , Sugimoto S , Orita N , Takayama H , Okada H , Thi Bich PD , Iwabuchi S , Hashimoto S , Ide M , Tabata N , Ito S , Matsushima K , Yanagawa H , Yamashita T , Kaneko S , Honda M |
| Ref : Hepatol Commun , 7 :e0206 , 2023 |
| Abstract : |
| PubMedSearch : Shirasaki_2023_Hepatol.Commun_7_e0206 |
| PubMedID: 37655967 |
| Gene_locus related to this paper: human-LIPG |
| Title : Mechanistic analysis of endothelial lipase G promotion of the occurrence and development of cervical carcinoma by activating the phosphatidylinositol-4,5-bisphosphate 3-kinase\/protein kinase B\/mechanistic target of rapamycin kinase signalling pathway - Huang_2023_J.Obstet.Gynaecol_43_2151353 |
| Author(s) : Huang J , Liu R , Zhang Y , Sheng X |
| Ref : J Obstet Gynaecol , 43 :2151353 , 2023 |
| Abstract : |
| PubMedSearch : Huang_2023_J.Obstet.Gynaecol_43_2151353 |
| PubMedID: 36606668 |
| Gene_locus related to this paper: human-LIPG |
| Title : Plasma HDL pattern, cholesterol efflux and cholesterol loading capacity of serum in carriers of a novel missense variant (Gly176Trp) of endothelial lipase - Pisciotta_2022_J.Clin.Lipidol_S1933-2874_00235 |
| Author(s) : Pisciotta L , Ossoli A , Ronca A , Garuti A , Fresa R , Favari E , Calabresi L , Calandra S , Bertolini S |
| Ref : J Clin Lipidol , : , 2022 |
| Abstract : |
| PubMedSearch : Pisciotta_2022_J.Clin.Lipidol_S1933-2874_00235 |
| PubMedID: 36002365 |
| Gene_locus related to this paper: human-LIPG |
| Title : LIPG is a novel prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma - Wang_2022_J.Clin.Lab.Anal__e24824 |
| Author(s) : Wang S , Chen Z , Lv H , Wang C , Wei H , Yu J |
| Ref : J Clin Lab Anal , :e24824 , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_J.Clin.Lab.Anal__e24824 |
| PubMedID: 36572999 |
| Gene_locus related to this paper: human-LIPG |
| Title : A Proof-of-Concept Inhibitor of Endothelial Lipase Suppresses Triple-Negative Breast Cancer Cells by Hijacking the Mitochondrial Function - Yang_2022_Cancers.(Basel)_14_3763 |
| Author(s) : Yang R , Han S , Clayton J , Haghighatian M , Tsai CC , Yao Y , Li P , Shen J , Zhou Q |
| Ref : Cancers (Basel) , 14 :3763 , 2022 |
| Abstract : |
| PubMedSearch : Yang_2022_Cancers.(Basel)_14_3763 |
| PubMedID: 35954428 |
| Gene_locus related to this paper: human-LIPG |
| Title : Sphingosine-1-phosphate: metabolism, transport, atheroprotection and effect of statin treatment - Therond_2022_Curr.Opin.Lipidol_33_199 |
| Author(s) : Therond P , Chapman MJ |
| Ref : Curr Opin Lipidol , 33 :199 , 2022 |
| Abstract : |
| PubMedSearch : Therond_2022_Curr.Opin.Lipidol_33_199 |
| PubMedID: 35695616 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins - Khetarpal_2021_PLoS.Genet_17_e1009802 |
| Author(s) : Khetarpal SA , Vitali C , Levin MG , Klarin D , Park J , Pampana A , Millar JS , Kuwano T , Sugasini D , Subbaiah PV , Billheimer JT , Natarajan P , Rader DJ |
| Ref : PLoS Genet , 17 :e1009802 , 2021 |
| Abstract : |
| PubMedSearch : Khetarpal_2021_PLoS.Genet_17_e1009802 |
| PubMedID: 34543263 |
| Gene_locus related to this paper: mouse-Lipg , human-LIPG |
| Title : LIPG endothelial lipase and breast cancer risk by subtypes - Gago-Dominguez_2021_Sci.Rep_11_10436 |
| Author(s) : Gago-Dominguez M , Redondo CM , Calaza M , Matabuena M , Bermudez MA , Perez-Fernandez R , Torres-Espanol M , Carracedo A , Castelao JE |
| Ref : Sci Rep , 11 :10436 , 2021 |
| Abstract : |
| PubMedSearch : Gago-Dominguez_2021_Sci.Rep_11_10436 |
| PubMedID: 34001944 |
| Gene_locus related to this paper: human-LIPG |
| Title : LIPG: an inflammation and cancer modulator - Hong_2021_Cancer.Gene.Ther_28_27 |
| Author(s) : Hong C , Deng R , Wang P , Lu X , Zhao X , Wang X , Cai R , Lin J |
| Ref : Cancer Gene Therapy , 28 :27 , 2021 |
| Abstract : |
| PubMedSearch : Hong_2021_Cancer.Gene.Ther_28_27 |
| PubMedID: 32572177 |
| Gene_locus related to this paper: human-LIPG |
| Title : Significant association between the endothelial lipase gene 584C\/T polymorphism and coronary artery disease risk - Wu_2020_Biosci.Rep_40_ |
| Author(s) : Wu YE , Ma L , Zhang H , Chen XR , Xu XY , Hu ZP |
| Ref : Bioscience Reports , 40 : , 2020 |
| Abstract : |
| PubMedSearch : Wu_2020_Biosci.Rep_40_ |
| PubMedID: 32893849 |
| Gene_locus related to this paper: human-LIPG |
| Title : LIPG SNPs, their haplotypes and gene-environment interactions on serum lipid levels - Yang_2019_Lipids.Health.Dis_18_10 |
| Author(s) : Yang S , Yin RX , Miao L , Zhou YG , Wu J , Zhang QH |
| Ref : Lipids Health Dis , 18 :10 , 2019 |
| Abstract : |
| PubMedSearch : Yang_2019_Lipids.Health.Dis_18_10 |
| PubMedID: 30621702 |
| Gene_locus related to this paper: human-LIPG |
| Title : Benzothiazole-based compounds as potent endothelial lipase inhibitors - Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| Author(s) : Meng W , Adam LP , Behnia K , Zhao L , Yang R , Kopcho LM , Locke GA , Taylor DS , Yin X , Wexler RR , Finlay H |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126673 , 2019 |
| Abstract : |
| PubMedSearch : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedID: 31519373 |
| Gene_locus related to this paper: human-LIPG |
| Title : Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase - Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| Author(s) : Kim SH , Johnson JA , Jiang J , Parkhurst B , Phillips M , Pi Z , Qiao JX , Tora G , Ye Chen A , Liu E , Yin X , Yang R , Zhao L , Taylor DS , Basso M , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 29 :1918 , 2019 |
| Abstract : |
| PubMedSearch : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedID: 31176700 |
| Gene_locus related to this paper: human-LIPG |
| Title : LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer - Lo_2018_Elife_7_e31334 |
| Author(s) : Lo PK , Yao Y , Lee JS , Zhang Y , Huang W , Kane MA , Zhou Q |
| Ref : Elife , 7 : , 2018 |
| Abstract : |
| PubMedSearch : Lo_2018_Elife_7_e31334 |
| PubMedID: 29350614 |
| Gene_locus related to this paper: human-LIPG |
| Title : PK\/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor - Hangeland_2018_ACS.Med.Chem.Lett_9_673 |
| Author(s) : Hangeland JJ , Abell LM , Adam LP , Jiang J , Friends TJ , Haque LE , Neels J , Onorato JM , Chen AYA , Taylor DS , Yin X , Harrity TW , Basso MD , Yang R , Sleph PG , Gordon DA , Huang CS , Wexler RR , Finlay HJ , Lawrence RM |
| Ref : ACS Med Chem Lett , 9 :673 , 2018 |
| Abstract : |
| PubMedSearch : Hangeland_2018_ACS.Med.Chem.Lett_9_673 |
| PubMedID: 30034599 |
| Gene_locus related to this paper: human-LIPG |
| Title : Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase - Johnson_2018_ACS.Med.Chem.Lett_9_1263 |
| Author(s) : Johnson JA , Tora G , Pi Z , Phillips M , Yin X , Yang R , Zhao L , Chen AY , Taylor DS , Basso M , Rose A , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Galella M , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : ACS Med Chem Lett , 9 :1263 , 2018 |
| Abstract : |
| PubMedSearch : Johnson_2018_ACS.Med.Chem.Lett_9_1263 |
| PubMedID: 30613337 |
| Gene_locus related to this paper: human-LIPG |
| Title : Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits - Wang_2017_Arterioscler.Thromb.Vasc.Biol_37_1282 |
| Author(s) : Wang C , Nishijima K , Kitajima S , Niimi M , Yan H , Chen Y , Ning B , Matsuhisa F , Liu E , Zhang J , Chen YE , Fan J |
| Ref : Arterioscler Thromb Vasc Biol , 37 :1282 , 2017 |
| Abstract : |
| PubMedSearch : Wang_2017_Arterioscler.Thromb.Vasc.Biol_37_1282 |
| PubMedID: 28546217 |
| Gene_locus related to this paper: human-LIPG |
| Title : Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms - Amin_2017_Mol.Psychiatry_22_537 |
| Author(s) : Amin N , Jovanova O , Adams HH , Dehghan A , Kavousi M , Vernooij MW , Peeters RP , de Vrij FM , van der Lee SJ , van Rooij JG , van Leeuwen EM , Chaker L , Demirkan A , Hofman A , Brouwer RW , Kraaij R , Willems van Dijk K , Hankemeier T , van Ijcken WF , Uitterlinden AG , Niessen WJ , Franco OH , Kushner SA , Ikram MA , Tiemeier H , van Duijn CM |
| Ref : Mol Psychiatry , 22 :537 , 2017 |
| Abstract : |
| PubMedSearch : Amin_2017_Mol.Psychiatry_22_537 |
| PubMedID: 27431295 |
| Gene_locus related to this paper: human-LIPG |
| Title : FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth - Slebe_2016_Nat.Commun_7_11199 |
| Author(s) : Slebe F , Rojo F , Vinaixa M , Garcia-Rocha M , Testoni G , Guiu M , Planet E , Samino S , Arenas EJ , Beltran A , Rovira A , Lluch A , Salvatella X , Yanes O , Albanell J , Guinovart JJ , Gomis RR |
| Ref : Nat Commun , 7 :11199 , 2016 |
| Abstract : |
| PubMedSearch : Slebe_2016_Nat.Commun_7_11199 |
| PubMedID: 27045898 |
| Gene_locus related to this paper: human-LIPG |
| Title : Association of endothelial lipase gene-384A\/C with coronary artery disease in Han Chinese people - Xie_2015_BMJ.Open_5_e007621 |
| Author(s) : Xie L , Sun Y , Tong Y , Liu Y , Deng Y |
| Ref : BMJ Open , 5 :e007621 , 2015 |
| Abstract : |
| PubMedSearch : Xie_2015_BMJ.Open_5_e007621 |
| PubMedID: 26124511 |
| Gene_locus related to this paper: human-LIPG |
| Title : Investigation of the Association Between 584C\/T Polymorphism of EL Gene and Risk of Premature Coronary Artery Disease in Fars Province - Toosi_2015_J.Cardiovasc.Thorac.Res_7_118 |
| Author(s) : Toosi S , Senemar S , Ahmadi Z , Radmanesh S |
| Ref : J Cardiovasc Thorac Res , 7 :118 , 2015 |
| Abstract : |
| PubMedSearch : Toosi_2015_J.Cardiovasc.Thorac.Res_7_118 |
| PubMedID: 26430500 |
| Gene_locus related to this paper: human-LIPG |
| Title : Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity - Miksztowicz_2014_Arterioscler.Thromb.Vasc.Biol_34_669 |
| Author(s) : Miksztowicz V , Schreier L , McCoy M , Lucero D , Fassio E , Billheimer J , Rader DJ , Berg G |
| Ref : Arterioscler Thromb Vasc Biol , 34 :669 , 2014 |
| Abstract : |
| PubMedSearch : Miksztowicz_2014_Arterioscler.Thromb.Vasc.Biol_34_669 |
| PubMedID: 24458708 |
| Gene_locus related to this paper: human-LIPC , human-LPL , human-LIPG |
| Title : Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species - Yang_2014_Lipids_49_505 |
| Author(s) : Yang Y , Kuwano T , Lagor WR , Albert CJ , Brenton S , Rader DJ , Ford DA , Brown RJ |
| Ref : Lipids , 49 :505 , 2014 |
| Abstract : |
| PubMedSearch : Yang_2014_Lipids_49_505 |
| PubMedID: 24777581 |
| Gene_locus related to this paper: human-LIPC , human-LIPG |
| Title : Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins - Yang_2014_Lipids_49_987 |
| Author(s) : Yang P , Belikova NA , Billheimer J , Rader DJ , Hill JS , Subbaiah PV |
| Ref : Lipids , 49 :987 , 2014 |
| Abstract : |
| PubMedSearch : Yang_2014_Lipids_49_987 |
| PubMedID: 25167836 |
| Gene_locus related to this paper: human-LIPG |
| Title : Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population - Cai_2014_Genet.Mol.Res_13_1059 |
| Author(s) : Cai GJ , He GP , Huang ZY , Qi CP |
| Ref : Genet Mol Res , 13 :1059 , 2014 |
| Abstract : |
| PubMedSearch : Cai_2014_Genet.Mol.Res_13_1059 |
| PubMedID: 24634127 |
| Gene_locus related to this paper: human-LIPG |
| Title : The associations between endothelial lipase 584C\/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis - Cai_2014_Lipids.Health.Dis_13_85 |
| Author(s) : Cai G , Huang Z , Zhang B , Weng W , Shi G |
| Ref : Lipids Health Dis , 13 :85 , 2014 |
| Abstract : |
| PubMedSearch : Cai_2014_Lipids.Health.Dis_13_85 |
| PubMedID: 24886585 |
| Gene_locus related to this paper: human-LIPG |
| Title : Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics - Larach_2013_Clin.Lipidol_8_635 |
| Author(s) : Larach DB , Cuchel M , Rader DJ |
| Ref : Clin Lipidol , 8 :635 , 2013 |
| Abstract : |
| PubMedSearch : Larach_2013_Clin.Lipidol_8_635 |
| PubMedID: 25374625 |
| Gene_locus related to this paper: human-LIPG |
| Title : Genetic and structure-function studies of missense mutations in human endothelial lipase - Razzaghi_2013_PLoS.One_8_e55716 |
| Author(s) : Razzaghi H , Tempczyk-Russell A , Haubold K , Santorico SA , Shokati T , Christians U , Churchill ME |
| Ref : PLoS ONE , 8 :e55716 , 2013 |
| Abstract : |
| PubMedSearch : Razzaghi_2013_PLoS.One_8_e55716 |
| PubMedID: 23536757 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium - Tatematsu_2013_Arterioscler.Thromb.Vasc.Biol_33_1788 |
| Author(s) : Tatematsu S , Francis SA , Natarajan P , Rader DJ , Saghatelian A , Brown JD , Michel T , Plutzky J |
| Ref : Arterioscler Thromb Vasc Biol , 33 :1788 , 2013 |
| Abstract : |
| PubMedSearch : Tatematsu_2013_Arterioscler.Thromb.Vasc.Biol_33_1788 |
| PubMedID: 23723371 |
| Gene_locus related to this paper: human-LIPG |
| Title : The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development - Dalan_2013_Mol.Biol.Rep_40_5143 |
| Author(s) : Dalan AB , Toptas B , Bugra Z , Polat N , Yilmaz-Aydogan H , Cimen A , Isbir T |
| Ref : Mol Biol Rep , 40 :5143 , 2013 |
| Abstract : |
| PubMedSearch : Dalan_2013_Mol.Biol.Rep_40_5143 |
| PubMedID: 23673478 |
| Gene_locus related to this paper: human-LIPG |
| Title : Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways - Essaji_2013_Lipids_48_769 |
| Author(s) : Essaji Y , Yang Y , Albert CJ , Ford DA , Brown RJ |
| Ref : Lipids , 48 :769 , 2013 |
| Abstract : |
| PubMedSearch : Essaji_2013_Lipids_48_769 |
| PubMedID: 23794138 |
| Gene_locus related to this paper: human-LIPG |
| Title : Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice - Sun_2013_Bioorg.Med.Chem_21_7724 |
| Author(s) : Sun S , Dean R , Jia Q , Zenova A , Zhong J , Grayson C , Xie C , Lindgren A , Samra P , Sojo L , van Heek M , Lin L , Percival D , Fu JM , Winther MD , Zhang Z |
| Ref : Bioorganic & Medicinal Chemistry , 21 :7724 , 2013 |
| Abstract : |
| PubMedSearch : Sun_2013_Bioorg.Med.Chem_21_7724 |
| PubMedID: 24211162 |
| Gene_locus related to this paper: human-LIPG |
| Title : Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels - Razzaghi_2012_Front.Genet_3_89 |
| Author(s) : Razzaghi H , Santorico SA , Kamboh MI |
| Ref : Front Genet , 3 :89 , 2012 |
| Abstract : |
| PubMedSearch : Razzaghi_2012_Front.Genet_3_89 |
| PubMedID: 22723803 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes - Connelly_2012_J.Histochem.Cytochem_60_694 |
| Author(s) : Connelly MA , D'Andrea MR , Qi J , Dzordzorme KC , Damiano BP |
| Ref : Journal of Histochemistry & Cytochemistry , 60 :694 , 2012 |
| Abstract : |
| PubMedSearch : Connelly_2012_J.Histochem.Cytochem_60_694 |
| PubMedID: 22740344 |
| Gene_locus related to this paper: human-LIPG |
| Title : Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport - Annema_2011_Curr.Atheroscler.Rep_13_257 |
| Author(s) : Annema W , Tietge UJ |
| Ref : Curr Atheroscler Rep , 13 :257 , 2011 |
| Abstract : |
| PubMedSearch : Annema_2011_Curr.Atheroscler.Rep_13_257 |
| PubMedID: 21424685 |
| Gene_locus related to this paper: human-LIPC , human-LIPG |
| Title : Interactions of the LIPG 584C>T polymorphism and alcohol consumption on serum lipid levels - Liu_2011_Alcohol_45_681 |
| Author(s) : Liu WY , Yin RX , Zhang L , Wu DF , Htet Aung LH , Hu XJ , Cao XL , Miao L |
| Ref : Alcohol , 45 :681 , 2011 |
| Abstract : |
| PubMedSearch : Liu_2011_Alcohol_45_681 |
| PubMedID: 21816559 |
| Gene_locus related to this paper: human-LIPG |
| Title : Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol - Edmondson_2011_Circ.Cardiovasc.Genet_4_145 |
| Author(s) : Edmondson AC , Braund PS , Stylianou IM , Khera AV , Nelson CP , Wolfe ML , Derohannessian SL , Keating BJ , Qu L , He J , Tobin MD , Tomaszewski M , Baumert J , Klopp N , Doring A , Thorand B , Li M , Reilly MP , Koenig W , Samani NJ , Rader DJ |
| Ref : Circ Cardiovasc Genet , 4 :145 , 2011 |
| Abstract : |
| PubMedSearch : Edmondson_2011_Circ.Cardiovasc.Genet_4_145 |
| PubMedID: 21303902 |
| Gene_locus related to this paper: human-LIPG |
| Title : Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol - Khetarpal_2011_PLoS.Genet_7_e1002393 |
| Author(s) : Khetarpal SA , Edmondson AC , Raghavan A , Neeli H , Jin W , Badellino KO , Demissie S , Manning AK , Derohannessian SL , Wolfe ML , Cupples LA , Li M , Kathiresan S , Rader DJ |
| Ref : PLoS Genet , 7 :e1002393 , 2011 |
| Abstract : |
| PubMedSearch : Khetarpal_2011_PLoS.Genet_7_e1002393 |
| PubMedID: 22174694 |
| Gene_locus related to this paper: human-LIPG |
| Title : Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients - Durlach_2011_Diabetes.Metab_37_64 |
| Author(s) : Durlach V , Durlach A , Movesayan I , Socquard E , Zellner C , Clavel C , Nazeyrollas P , Malloy MJ , Pullinger CR , Kane JP , Ducasse A , Aouizerat BE |
| Ref : Diabetes Metab , 37 :64 , 2011 |
| Abstract : |
| PubMedSearch : Durlach_2011_Diabetes.Metab_37_64 |
| PubMedID: 21145773 |
| Gene_locus related to this paper: human-LIPG |
| Title : A novel fluorogenic substrate for the measurement of endothelial lipase activity - Darrow_2011_J.Lipid.Res_52_374 |
| Author(s) : Darrow AL , Olson MW , Xin H , Burke SL , Smith C , Schalk-Hihi C , Williams R , Bayoumy SS , Deckman IC , Todd MJ , Damiano BP , Connelly MA |
| Ref : J Lipid Res , 52 :374 , 2011 |
| Abstract : |
| PubMedSearch : Darrow_2011_J.Lipid.Res_52_374 |
| PubMedID: 21062953 |
| Gene_locus related to this paper: human-LIPG |
| Title : Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins - Brown_2010_Circ.Res_107_357 |
| Author(s) : Brown RJ , Lagor WR , Sankaranaravanan S , Yasuda T , Quertermous T , Rothblat GH , Rader DJ |
| Ref : Circulation Research , 107 :357 , 2010 |
| Abstract : |
| PubMedSearch : Brown_2010_Circ.Res_107_357 |
| PubMedID: 20558822 |
| Gene_locus related to this paper: human-LIPC , human-LIPG |
| Title : Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT - Vergeer_2010_Atherosclerosis_211_558 |
| Author(s) : Vergeer M , Cohn DM , Boekholdt SM , Sandhu MS , Prins HM , Ricketts SL , Wareham NJ , Kastelein JJ , Khaw KT , Kamphuisen PW , Dallinga-Thie GM |
| Ref : Atherosclerosis , 211 :558 , 2010 |
| Abstract : |
| PubMedSearch : Vergeer_2010_Atherosclerosis_211_558 |
| PubMedID: 20466371 |
| Gene_locus related to this paper: human-LIPG |
| Title : Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo - Kojima_2010_Cardiovasc.Res_87_385 |
| Author(s) : Kojima Y , Ishida T , Sun L , Yasuda T , Toh R , Rikitake Y , Fukuda A , Kume N , Koshiyama H , Taniguchi A , Hirata K |
| Ref : Cardiovascular Research , 87 :385 , 2010 |
| Abstract : |
| PubMedSearch : Kojima_2010_Cardiovasc.Res_87_385 |
| PubMedID: 20045866 |
| Gene_locus related to this paper: human-LIPG |
| Title : Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia - Tanaka_2009_J.Atheroscler.Thromb_16_327 |
| Author(s) : Tanaka H , Ishida T , Johnston TP , Yasuda T , Ueyama T , Kojima Y , Kundu RK , Quertermous T , Ishikawa Y , Hirata K |
| Ref : J Atheroscler Thromb , 16 :327 , 2009 |
| Abstract : |
| PubMedSearch : Tanaka_2009_J.Atheroscler.Thromb_16_327 |
| PubMedID: 19672025 |
| Gene_locus related to this paper: human-LIPG |
| Title : The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations - Jensen_2009_Eur.Heart.J_30_1584 |
| Author(s) : Jensen MK , Rimm EB , Mukamal KJ , Edmondson AC , Rader DJ , Vogel U , Tjonneland A , Sorensen TI , Schmidt EB , Overvad K |
| Ref : Eur Heart J , 30 :1584 , 2009 |
| Abstract : |
| PubMedSearch : Jensen_2009_Eur.Heart.J_30_1584 |
| PubMedID: 19411665 |
| Gene_locus related to this paper: human-LIPG |
| Title : Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - Smith_2009_Atherosclerosis_206_500 |
| Author(s) : Smith CE , Arnett DK , Tsai MY , Lai CQ , Parnell LD , Shen J , Laclaustra M , Junyent M , Ordovas JM |
| Ref : Atherosclerosis , 206 :500 , 2009 |
| Abstract : |
| PubMedSearch : Smith_2009_Atherosclerosis_206_500 |
| PubMedID: 19380136 |
| Gene_locus related to this paper: human-LIPG |
| Title : A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis - Brown_2009_J.Lipid.Res_50_1910 |
| Author(s) : Brown RJ , Edmondson AC , Griffon N , Hill TB , Fuki IV , Badellino KO , Li M , Wolfe ML , Reilly MP , Rader DJ |
| Ref : J Lipid Res , 50 :1910 , 2009 |
| Abstract : |
| PubMedSearch : Brown_2009_J.Lipid.Res_50_1910 |
| PubMedID: 19411705 |
| Gene_locus related to this paper: human-LIPG |
| Title : Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors - Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| Author(s) : Goodman KB , Bury MJ , Cheung M , Cichy-Knight MA , Dowdell SE , Dunn AK , Lee D , Lieby JA , Moore ML , Scherzer DA , Sha D , Suarez DP , Murphy DJ , Harpel MR , Manas ES , McNulty DE , Annan RS , Matico RE , Schwartz BK , Trill JJ , Sweitzer TD , Wang DY , Keller PM , Krawiec JA , Jaye MC |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :27 , 2009 |
| Abstract : |
| PubMedSearch : Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| PubMedID: 19058966 |
| Gene_locus related to this paper: human-LIPG |
| Title : Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans - Edmondson_2009_J.Clin.Invest_119_1042 |
| Author(s) : Edmondson AC , Brown RJ , Kathiresan S , Cupples LA , Demissie S , Manning AK , Jensen MK , Rimm EB , Wang J , Rodrigues A , Bamba V , Khetarpal SA , Wolfe ML , Derohannessian S , Li M , Reilly MP , Aberle J , Evans D , Hegele RA , Rader DJ |
| Ref : J Clinical Investigation , 119 :1042 , 2009 |
| Abstract : |
| PubMedSearch : Edmondson_2009_J.Clin.Invest_119_1042 |
| PubMedID: 19287092 |
| Gene_locus related to this paper: human-LIPG |
| Title : Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population - Tang_2008_J.Lipid.Res_49_369 |
| Author(s) : Tang NP , Wang LS , Yang L , Zhou B , Gu HJ , Sun QM , Cong RH , Zhu HJ , Wang B |
| Ref : J Lipid Res , 49 :369 , 2008 |
| Abstract : |
| PubMedSearch : Tang_2008_J.Lipid.Res_49_369 |
| PubMedID: 17986713 |
| Gene_locus related to this paper: human-LIPG |
| Title : A high-throughput screen for endothelial lipase using HDL as substrate - Keller_2008_J.Biomol.Screen_13_468 |
| Author(s) : Keller PM , Rust T , Murphy DJ , Matico R , Trill JJ , Krawiec JA , Jurewicz A , Jaye M , Harpel M , Thrall S , Schwartz B |
| Ref : J Biomol Screen , 13 :468 , 2008 |
| Abstract : |
| PubMedSearch : Keller_2008_J.Biomol.Screen_13_468 |
| PubMedID: 18566479 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels - Shimizu_2007_Circ.J_71_842 |
| Author(s) : Shimizu M , Kanazawa K , Hirata K , Ishida T , Hiraoka E , Matsuda Y , Iwai C , Miyamoto Y , Hashimoto M , Kajiya T , Akita H , Yokoyama M |
| Ref : Circ J , 71 :842 , 2007 |
| Abstract : |
| PubMedSearch : Shimizu_2007_Circ.J_71_842 |
| PubMedID: 17526978 |
| Gene_locus related to this paper: human-LIPG |
| Title : Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase - Shimamura_2007_Arterioscler.Thromb.Vasc.Biol_27_366 |
| Author(s) : Shimamura M , Matsuda M , Yasumo H , Okazaki M , Fujimoto K , Kono K , Shimizugawa T , Ando Y , Koishi R , Kohama T , Sakai N , Kotani K , Komuro R , Ishida T , Hirata K , Yamashita S , Furukawa H , Shimomura I |
| Ref : Arterioscler Thromb Vasc Biol , 27 :366 , 2007 |
| Abstract : |
| PubMedSearch : Shimamura_2007_Arterioscler.Thromb.Vasc.Biol_27_366 |
| PubMedID: 17110602 |
| Gene_locus related to this paper: human-LIPG |
| Title : Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues - Chen_2007_Biochim.Biophys.Acta_1771_1319 |
| Author(s) : Chen S , Subbaiah PV |
| Ref : Biochimica & Biophysica Acta , 1771 :1319 , 2007 |
| Abstract : |
| PubMedSearch : Chen_2007_Biochim.Biophys.Acta_1771_1319 |
| PubMedID: 17905648 |
| Gene_locus related to this paper: human-LIPG |
| Title : Fluorogenic substrates for high-throughput measurements of endothelial lipase activity - Mitnaul_2007_J.Lipid.Res_48_472 |
| Author(s) : Mitnaul LJ , Tian J , Burton C , Lam MH , Zhu Y , Olson SH , Schneeweis JE , Zuck P , Pandit S , Anderson M , Maletic MM , Waddell ST , Wright SD , Sparrow CP , Lund EG |
| Ref : J Lipid Res , 48 :472 , 2007 |
| Abstract : |
| PubMedSearch : Mitnaul_2007_J.Lipid.Res_48_472 |
| PubMedID: 17090660 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase: its role in cardiovascular disease - Paradis_2006_Can.J.Cardiol_22 Suppl B_31B |
| Author(s) : Paradis ME , Lamarche B |
| Ref : Can J Cardiol , 22 Suppl B :31B , 2006 |
| Abstract : |
| PubMedSearch : Paradis_2006_Can.J.Cardiol_22 Suppl B_31B |
| PubMedID: 16498510 |
| Gene_locus related to this paper: human-LIPG |
| Title : Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans - Hutter_2006_Atherosclerosis_185_78 |
| Author(s) : Hutter CM , Austin MA , Farin FM , Viernes HM , Edwards KL , Leonetti DL , McNeely MJ , Fujimoto WY |
| Ref : Atherosclerosis , 185 :78 , 2006 |
| Abstract : |
| PubMedSearch : Hutter_2006_Atherosclerosis_185_78 |
| PubMedID: 16023652 |
| Gene_locus related to this paper: human-LIPG |
| Title : Long-chain polyunsaturated fatty acids, endothelial lipase and atherosclerosis - Das_2005_Prostaglandins.Leukot.Essent.Fatty.Acids_72_173 |
| Author(s) : Das UN |
| Ref : Prostaglandins Leukot Essent Fatty Acids , 72 :173 , 2005 |
| Abstract : |
| PubMedSearch : Das_2005_Prostaglandins.Leukot.Essent.Fatty.Acids_72_173 |
| PubMedID: 15664301 |
| Gene_locus related to this paper: human-LIPG |
| Title : DNA sequence and analysis of human chromosome 18 - Nusbaum_2005_Nature_437_551 |
| Author(s) : Nusbaum C , Zody MC , Borowsky ML , Kamal M , Kodira CD , Taylor TD , Whittaker CA , Chang JL , Cuomo CA , Dewar K , Fitzgerald MG , Yang X , Abouelleil A , Allen NR , Anderson S , Bloom T , Bugalter B , Butler J , Cook A , Decaprio D , Engels R , Garber M , Gnirke A , Hafez N , Hall JL , Norman CH , Itoh T , Jaffe DB , Kuroki Y , Lehoczky J , Lui A , Macdonald P , Mauceli E , Mikkelsen TS , Naylor JW , Nicol R , Nguyen C , Noguchi H , O'Leary SB , O'Neill K , Piqani B , Smith CL , Talamas JA , Topham K , Totoki Y , Toyoda A , Wain HM , Young SK , Zeng Q , Zimmer AR , Fujiyama A , Hattori M , Birren BW , Sakaki Y , Lander ES |
| Ref : Nature , 437 :551 , 2005 |
| Abstract : |
| PubMedSearch : Nusbaum_2005_Nature_437_551 |
| PubMedID: 16177791 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine - Gauster_2005_J.Lipid.Res_46_1517 |
| Author(s) : Gauster M , Rechberger G , Sovic A , Horl G , Steyrer E , Sattler W , Frank S |
| Ref : J Lipid Res , 46 :1517 , 2005 |
| Abstract : |
| PubMedSearch : Gauster_2005_J.Lipid.Res_46_1517 |
| PubMedID: 15834125 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase and cholesterol metabolism - Cilingiroglu_2004_Curr.Atheroscler.Rep_6_126 |
| Author(s) : Cilingiroglu M , Ballantyne C |
| Ref : Curr Atheroscler Rep , 6 :126 , 2004 |
| Abstract : |
| PubMedSearch : Cilingiroglu_2004_Curr.Atheroscler.Rep_6_126 |
| PubMedID: 15023297 |
| Gene_locus related to this paper: human-LIPG |
| Title : Structural basis of endothelial lipase tropism for HDL - Broedl_2004_FASEB.J_18_1891 |
| Author(s) : Broedl UC , Jin W , Fuki IV , Glick JM , Rader DJ |
| Ref : FASEB Journal , 18 :1891 , 2004 |
| Abstract : |
| PubMedSearch : Broedl_2004_FASEB.J_18_1891 |
| PubMedID: 15456739 |
| Gene_locus related to this paper: human-LIPG |
| Title : Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels - Mank-Seymour_2004_Biochim.Biophys.Acta_1636_40 |
| Author(s) : Mank-Seymour AR , Durham KL , Thompson JF , Seymour AB , Milos PM |
| Ref : Biochimica & Biophysica Acta , 1636 :40 , 2004 |
| Abstract : |
| PubMedSearch : Mank-Seymour_2004_Biochim.Biophys.Acta_1636_40 |
| PubMedID: 14984737 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation - Broedl_2004_Trends.Cardiovasc.Med_14_202 |
| Author(s) : Broedl UC , Jin W , Rader DJ |
| Ref : Trends Cardiovasc Med , 14 :202 , 2004 |
| Abstract : |
| PubMedSearch : Broedl_2004_Trends.Cardiovasc.Med_14_202 |
| PubMedID: 15261893 |
| Gene_locus related to this paper: human-LIPG |
| Title : The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women - Paradis_2003_J.Lipid.Res_44_1902 |
| Author(s) : Paradis ME , Couture P , Bosse Y , Despres JP , Perusse L , Bouchard C , Vohl MC , Lamarche B |
| Ref : J Lipid Res , 44 :1902 , 2003 |
| Abstract : |
| PubMedSearch : Paradis_2003_J.Lipid.Res_44_1902 |
| PubMedID: 12867537 |
| Gene_locus related to this paper: human-LIPG |
| Title : Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids - Duong_2003_Biochemistry_42_13778 |
| Author(s) : Duong M , Psaltis M , Rader DJ , Marchadier D , Barter PJ , Rye KA |
| Ref : Biochemistry , 42 :13778 , 2003 |
| Abstract : |
| PubMedSearch : Duong_2003_Biochemistry_42_13778 |
| PubMedID: 14622025 |
| Gene_locus related to this paper: human-LIPC , human-LIPG |
| Title : Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway - Fuki_2003_J.Biol.Chem_278_34331 |
| Author(s) : Fuki IV , Blanchard N , Jin W , Marchadier DH , Millar JS , Glick JM , Rader DJ |
| Ref : Journal of Biological Chemistry , 278 :34331 , 2003 |
| Abstract : |
| PubMedSearch : Fuki_2003_J.Biol.Chem_278_34331 |
| PubMedID: 12810721 |
| Gene_locus related to this paper: human-LIPG |
| Title : Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children - Yamakawa-Kobayashi_2003_Hum.Genet_113_311 |
| Author(s) : Yamakawa-Kobayashi K , Yanagi H , Endo K , Arinami T , Hamaguchi H |
| Ref : Hum Genet , 113 :311 , 2003 |
| Abstract : |
| PubMedSearch : Yamakawa-Kobayashi_2003_Hum.Genet_113_311 |
| PubMedID: 12884003 |
| Gene_locus related to this paper: human-LIPG |
| Title : Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism - Ma_2003_Proc.Natl.Acad.Sci.U.S.A_100_2748 |
| Author(s) : Ma K , Cilingiroglu M , Otvos JD , Ballantyne CM , Marian AJ , Chan L |
| Ref : Proc Natl Acad Sci U S A , 100 :2748 , 2003 |
| Abstract : |
| PubMedSearch : Ma_2003_Proc.Natl.Acad.Sci.U.S.A_100_2748 |
| PubMedID: 12601178 |
| Gene_locus related to this paper: human-LIPG |
| Title : Characterization of the lipolytic activity of endothelial lipase - McCoy_2002_J.Lipid.Res_43_921 |
| Author(s) : McCoy MG , Sun GS , Marchadier D , Maugeais C , Glick JM , Rader DJ |
| Ref : J Lipid Res , 43 :921 , 2002 |
| Abstract : |
| PubMedSearch : McCoy_2002_J.Lipid.Res_43_921 |
| PubMedID: 12032167 |
| Gene_locus related to this paper: human-LIPG |
| Title : Cloning of a unique lipase from endothelial cells extends the lipase gene family. - |
| Author(s) : Hirata K , Dichek HL , Cioffi JA , Choi SY , Leeper NJ , Quintana L , Kronmal GS , Cooper AD , Quertermous T |
| Ref : Journal of Biological Chemistry , 274 :14170 , 1999 |
| PubMedID: 10318835 |
| Gene_locus related to this paper: human-LIPG , mouse-Lipg |
| Title : A novel endothelial-derived lipase that modulates HDL metabolism - Jaye_1999_Nat.Genet_21_424 |
| Author(s) : Jaye M , Lynch KJ , Krawiec J , Marchadier D , Maugeais C , Doan K , South V , Amin D , Perrone M , Rader DJ |
| Ref : Nat Genet , 21 :424 , 1999 |
| Abstract : |
| PubMedSearch : Jaye_1999_Nat.Genet_21_424 |
| PubMedID: 10192396 |
| Gene_locus related to this paper: human-LIPG |