Title : Nootropic candidates inhibit head-twitches induced by mescaline in mice - Yamamoto_1992_Jpn.J.Pharmacol_59_419 |
Author(s) : Yamamoto T , Ohno M , Yatsugi S , Fujikawa Y , Ueki S |
Ref : Japanese Journal of Pharmacology , 59 :419 , 1992 |
Abstract :
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches. |
PubMedSearch : Yamamoto_1992_Jpn.J.Pharmacol_59_419 |
PubMedID: 1434136 |
Inhibitor | NIK-247 |
Yamamoto T, Ohno M, Yatsugi S, Fujikawa Y, Ueki S (1992)
Nootropic candidates inhibit head-twitches induced by mescaline in mice
Japanese Journal of Pharmacology
59 :419
Yamamoto T, Ohno M, Yatsugi S, Fujikawa Y, Ueki S (1992)
Japanese Journal of Pharmacology
59 :419