NIK-247
Reversibly Inhibits AChE and BChE at one third of inhibition by tacrine. || IPIDACRINE AMIRIDINE Weak agonist of M2 muscarinic receptors which explains longterm potentiation in the hippocampus. This compound is a ring-constricted derivative of tacrine.NIK-247 is Ipidacrine hydrochloride hydrate IC50 hBCHE Amiridine.HCl 0.18 +/- 0.01 microM
General
Type : Quinoline, Derivative of Tacrine, Derivative of Amiridine
Chemical_Nomenclature : 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate || 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine
Canonical SMILES : C1CCC2=C(C1)C(=C3CCCC3=N2)N
InChI : InChI=1S\/C12H16N2\/c13-12-8-4-1-2-6-10(8)14-11-7-3-5-9(11)12\/h1-7H2,(H2,13,14)
InChIKey : YLUSMKAJIQOXPV-UHFFFAOYSA-N
Other name(s) : Ipidacrine || Amiridine || Amiridin || CHEMBL130880 || ZINC6780651 || DB13668 || Neiromidin
MW : 188.27
Formula : C12H16N2
CAS_number : 90043-86-0, 62732-44-9
PubChem : 604519
UniChem : YLUSMKAJIQOXPV-UHFFFAOYSA-N
Wikipedia : Ipidacrine
References (40)
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| Title : NIK-247 induces long-term potentiation of synaptic transmission in the CA1 region of rat hippocampal slices through M2 muscarinic receptors - Kojima_1998_Gen.Pharmacol_31_297 |
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| Title : Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats - Kimura_1992_Pharmacol.Biochem.Behav_43_985 |
| Author(s) : Kimura H , Yamada K , Nagashima M , Matsumoto S , Ishii Y , Yoshida S , Fujii K , Furukawa T |
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| PubMedSearch : Burov_1992_Biull.Eksp.Biol.Med_113_149 |
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| Title : [Effectiveness of amiridin in senile dementia of the Alzheimer type] - Bukatina_1991_Zh.Nevropatol.Psikhiatr.Im.S.S.Korsakova_91_53 |
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| PubMedSearch : Bukatina_1991_Zh.Nevropatol.Psikhiatr.Im.S.S.Korsakova_91_53 |
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| Title : NIK-247 blocks voltage-dependent ionic currents in crayfish axon - Kojima_1991_Jpn.J.Pharmacol_57_545 |
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| Ref : Japanese Journal of Pharmacology , 57 :545 , 1991 |
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