| Title : Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused gamma-Pyrone, and exo-Methylene Formation - Yamamoto_2015_Org.Lett_17_4992 |
| Author(s) : Yamamoto T , Tsunematsu Y , Noguchi H , Hotta K , Watanabe K |
| Ref : Org Lett , 17 :4992 , 2015 |
|
Abstract :
Successful activation of the pyranonigrin biosynthetic gene cluster and gene knockout in Aspergillus niger plus in vivo and in vitro assays led to isolation of six new products, including a spiro cyclobutane-containing dimeric compound, which served as the basis for the proposed comprehensive pyranonigrin biosynthetic pathway. Two redox enzymes are key to forming the characteristic fused gamma-pyrone core, and a protease homologue performs the exo-methylene formation. |
| PubMedSearch : Yamamoto_2015_Org.Lett_17_4992 |
| PubMedID: 26414728 |
| Gene_locus related to this paper: aspnc-pyni |
| Gene_locus | aspnc-pyni |
Yamamoto T, Tsunematsu Y, Noguchi H, Hotta K, Watanabe K (2015)
Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused gamma-Pyrone, and exo-Methylene Formation
Org Lett
17 :4992
Yamamoto T, Tsunematsu Y, Noguchi H, Hotta K, Watanabe K (2015)
Org Lett
17 :4992