Yamashita_1997_Vet.Hum.Toxicol_39_84

Reference

Title : Human mortality in organophosphate poisonings - Yamashita_1997_Vet.Hum.Toxicol_39_84
Author(s) : Yamashita M , Tanaka J , Ando Y
Ref : Vet Hum Toxicol , 39 :84 , 1997
Abstract : We reviewed 130 admissions of organophosphate poisoning and analyzed the causes of death. Fenitrothion, malathion, dichlorvos, trichlorfon and fenitrothion/malathion were the most frequent chemicals involved. Mortality was 25% (32/130); delay in discovery and transport (18 cases), insufficient respiratory management (8 cases), and severe underlying or co-existing diseases (6 cases) were noted in the lethalities. Insufficient respiratory management consisted of delay in endotracheal intubation (5 cases) and failure in weaning (3 cases). About 3/4 of the severely serum cholinesterase-depressed cases needed ventilators. This suggests that better respiratory management would improve the outcome of organophosphate poisonings. Close observation of the clinical symptoms is essential, and detection of changes in serum cholinesterase may be helpful.
ESTHER : Yamashita_1997_Vet.Hum.Toxicol_39_84
PubMedSearch : Yamashita_1997_Vet.Hum.Toxicol_39_84
PubMedID: 9080632

Related information

Citations formats

Yamashita M, Tanaka J, Ando Y (1997)
Human mortality in organophosphate poisonings
Vet Hum Toxicol 39 :84

Yamashita M, Tanaka J, Ando Y (1997)
Vet Hum Toxicol 39 :84

Array
(
    [id] => 48802
    [paper] => Yamashita_1997_Vet.Hum.Toxicol_39_84
    [author] => Yamashita M || Tanaka J || Ando Y
    [year] => 1997
    [title] => Human mortality in organophosphate poisonings
    [journal] => Vet Hum Toxicol
    [volume] => 39
    [page] => 84
    [medline] => 9080632
    [abstract] => Yamashita_1997_Vet.Hum.Toxicol_39_84
    [kin_reference] => 
    [mutation] => 
    [kinetic_parameter] => 
    [inhibitor] => Dichlorvos || Fenitrothion || Malathion || Trichlorfon~Metrifonate
    [kin_value] => 
    [substrate] => 
    [gene_locus] => Array
        (
        )

    [family] => 
    [interact_gene_locus] => 
    [xenobiotic_sensitivity] => 
    [news] => 
    [likid_reference] => 
    [lip_reference] => 
    [gene_locus_frgt] => 
    [structure] => 
    [comment] => 
    [chemical] => 
    [arpigny_jaeger] => 
    [reactivator] => 
    [disease] => 
    [enzyme] => 
    [risk_factor] => 
    [tissue] => 
    [sub_tissue] => 
    [activity] => 
    [specific_activity] => 
    [disease_by_interaction] => 
    [abstract_text] => Array
        (
            [id] => 5800
            [longtext] => Yamashita_1997_Vet.Hum.Toxicol_39_84
            [content] => We reviewed 130 admissions of organophosphate poisoning and analyzed the causes of death. Fenitrothion, malathion, dichlorvos, trichlorfon and fenitrothion/malathion were the most frequent chemicals involved. Mortality was 25% (32/130); delay in discovery and transport (18 cases), insufficient respiratory management (8 cases), and severe underlying or co-existing diseases (6 cases) were noted in the lethalities. Insufficient respiratory management consisted of delay in endotracheal intubation (5 cases) and failure in weaning (3 cases). About 3/4 of the severely serum cholinesterase-depressed cases needed ventilators. This suggests that better respiratory management would improve the outcome of organophosphate poisonings. Close observation of the clinical symptoms is essential, and detection of changes in serum cholinesterase may be helpful.
        )

)