| Title : Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1 - Yao_2012_FEBS.Lett_586_2522 |
| Author(s) : Yao XQ , Li XC , Zhang XX , Yin YY , Liu B , Luo DJ , Wang Q , Wang JZ , Liu GP |
| Ref : FEBS Letters , 586 :2522 , 2012 |
|
Abstract :
Protein phosphatase-2A (PP2A) activity is significantly suppressed in Alzheimer's disease. We have reported that glycogen synthase kinase-3beta (GSK-3beta) inhibits PP2A via upregulating the phosphorylation of PP2A catalytic subunit (PP2A(C)). Here we studied the effects of GSK-3beta on the inhibitory demethylation of PP2A at leucine-309 (dmL309-PP2A(C)). We found that GSK-3beta regulates dmL309-PP2A(C) level by regulating PME-1 and PPMT1. Knockdown of PME-1 or PPMT1 eliminated the effects of GSK-3beta on PP2A(C). GSK-3 could negatively regulate PP2A regulatory subunit protein level. We conclude that GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1. |
| PubMedSearch : Yao_2012_FEBS.Lett_586_2522 |
| PubMedID: 22732552 |
| Gene_locus related to this paper: human-PPME1 |
| Gene_locus | human-PPME1 |
Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP (2012)
Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1
FEBS Letters
586 :2522
Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP (2012)
FEBS Letters
586 :2522