human-PPME1

Homo sapiens (Human) protein phosphatase PP2A methylesterase-1 (EC 3.1.1.-) (pme-1)

Comment

PP2A dimethyl-esterase (PME-1). human Q9NVT5 CDNA FLJ10519 fis, clone NT2RP2000816, similar to a chelatase is identical to PME-1 || Q9UI18 pro0750

Relationship

Family : PPase_methylesterase_euk

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII SRVQCRIVAL DLRSHGETKV KNPEDLSAET MAKDVGNVVE AMYGDLPPPI MLIGHSMGGA IAVHTASSNL VPSLLGLCMI DVVEGTAMDA LNSMQNFLRG RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG ITSPEGSKSI VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA VHEDAPDKVA EAVATFLIRH RFAEPIGGFQ CVFPGC

References (26)

Title : PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers - Aakula_2023_Mol.Oncol_17_1007
Author(s) : Aakula A , Isomursu A , Rupp C , Erickson A , Gupta N , Kauko O , Shah P , Padzik A , Pokharel YR , Kaur A , Li SP , Trotman L , Taimen P , Rannikko A , Lammerding J , Paatero I , Mirtti T , Ivaska J , Westermarck J
Ref : Mol Oncol , 17 :1007 , 2023
PubMedID: 36461911
Gene_locus related to this paper: human-PPME1

Title : Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K\/Akt signaling, and promotes epithelial-mesenchymal transition - Ikeda_2023_Biochem.Biophys.Res.Commun_692_149148
Author(s) : Ikeda S , Sato K , Ohama T
Ref : Biochemical & Biophysical Research Communications , 692 :149148 , 2023
PubMedID: 38043157
Gene_locus related to this paper: human-PPME1

Title : Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition - Li_2022_Elife_11_e79736
Author(s) : Li Y , Balakrishnan VK , Rowse M , Wu CG , Bravos AP , Yadav VK , Ivarsson Y , Strack S , Novikova IV , Xing Y
Ref : Elife , 11 : , 2022
PubMedID: 35924897
Gene_locus related to this paper: human-PPME1

Title : Involvement of PP2A methylation in the adipogenic differentiation of bone marrow-derived mesenchymal stem cell - Ikeda_2020_J.Biochem_168_643
Author(s) : Ikeda S , Tsuji S , Ohama T , Sato K
Ref : J Biochem , 168 :643 , 2020
PubMedID: 32663263
Gene_locus related to this paper: human-PPME1

Title : DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p - Xu_2020_World.J.Gastroenterol_26_1745
Author(s) : Xu T , Lei T , Li SQ , Mai EH , Ding FH , Niu B
Ref : World J Gastroenterol , 26 :1745 , 2020
PubMedID: 32351291
Gene_locus related to this paper: human-PPME1

Title : Glycogen synthase kinase-3beta suppresses the expression of protein phosphatase methylesterase-1 through beta-catenin - Jin_2019_Aging.(Albany.NY)_11_9672
Author(s) : Jin N , Shi R , Jiang Y , Chu D , Gong CX , Iqbal K , Liu F
Ref : Aging (Albany NY) , 11 :9672 , 2019
PubMedID: 31714894
Gene_locus related to this paper: human-PPME1

Title : Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1 - Tang_2018_Life.Sci_213_166
Author(s) : Tang S , Lu C , Mo L , Wang X , Liang Z , Qin F , Liu Y , Huang H , Huang Y , Cai H , Xiao D , Guo S , Ouyang Y , Sun B , Li X
Ref : Life Sciences , 213 :166 , 2018
PubMedID: 30340029
Gene_locus related to this paper: human-PPME1

Title : PME-1 is regulated by USP36 in ERK and Akt signaling pathways - Kim_2018_FEBS.Lett_592_1575
Author(s) : Kim SY , Choi J , Lee DH , Park JH , Hwang YJ , Baek KH
Ref : FEBS Letters , 592 :1575 , 2018
PubMedID: 29577269
Gene_locus related to this paper: human-PPME1

Title : Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1 - Kaur_2016_Biochem.Soc.Trans_44_1683
Author(s) : Kaur A , Westermarck J
Ref : Biochemical Society Transactions , 44 :1683 , 2016
PubMedID: 27913678
Gene_locus related to this paper: human-PPME1

Title : Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models - Pusey_2016_Tumour.Biol_37_11835
Author(s) : Pusey M , Bail S , Xu Y , Buiakova O , Nestor M , Yang JJ , Rice LM
Ref : Tumour Biol , 37 :11835 , 2016
PubMedID: 27048286
Gene_locus related to this paper: human-PPME1

Title : Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin\/Proteasome Degradation - Yabe_2015_PLoS.One_10_e0145226
Author(s) : Yabe R , Miura A , Usui T , Mudrak I , Ogris E , Ohama T , Sato K
Ref : PLoS ONE , 10 :e0145226 , 2015
PubMedID: 26678046
Gene_locus related to this paper: human-PPME1 , mouse-PPME1

Title : A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size - Xia_2015_Cell.Cycle_14_1938
Author(s) : Xia X , Gholkar A , Senese S , Torres JZ
Ref : Cell Cycle , 14 :1938 , 2015
PubMedID: 25839665
Gene_locus related to this paper: human-PPME1

Title : Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium\/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1 - Lee_2014_J.Biol.Chem_289_21108
Author(s) : Lee CW , Yang FC , Chang HY , Chou H , Tan BC , Lee SC
Ref : Journal of Biological Chemistry , 289 :21108 , 2014
PubMedID: 24841198
Gene_locus related to this paper: human-PPME1

Title : Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target - Li_2014_Cancer.Biol.Ther_15_128
Author(s) : Li J , Han S , Qian Z , Su X , Fan S , Fu J , Liu Y , Yin X , Gao Z , Zhang J , Yu DH , Ji Q
Ref : Cancer Biol Ther , 15 :128 , 2014
PubMedID: 24253382
Gene_locus related to this paper: human-PPME1

Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656
Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR
Ref : Nat Chemical Biology , 10 :656 , 2014
PubMedID: 24997602
Gene_locus related to this paper: human-PPME1

Title : The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity - Sents_2013_Febs.j_280_644
Author(s) : Sents W , Ivanova E , Lambrecht C , Haesen D , Janssens V
Ref : Febs J , 280 :644 , 2013
PubMedID: 22443683
Gene_locus related to this paper: human-PPME1

Title : Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1 - Yao_2012_FEBS.Lett_586_2522
Author(s) : Yao XQ , Li XC , Zhang XX , Yin YY , Liu B , Luo DJ , Wang Q , Wang JZ , Liu GP
Ref : FEBS Letters , 586 :2522 , 2012
PubMedID: 22732552
Gene_locus related to this paper: human-PPME1

Title : Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors - Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
Author(s) : Bachovchin DA , Mohr JT , Speers AE , Wang C , Berlin JM , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Schurer SC , Nomura DK , Rosen H , Fu GC , Cravatt BF
Ref : Proc Natl Acad Sci U S A , 108 :6811 , 2011
PubMedID: 21398589
Gene_locus related to this paper: human-PPME1

Title : PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma - Puustinen_2009_Cancer.Res_69_2870
Author(s) : Puustinen P , Junttila MR , Vanhatupa S , Sablina AA , Hector ME , Teittinen K , Raheem O , Ketola K , Lin S , Kast J , Haapasalo H , Hahn WC , Westermarck J
Ref : Cancer Research , 69 :2870 , 2009
PubMedID: 19293187
Gene_locus related to this paper: human-PPME1

Title : Structural mechanism of demethylation and inactivation of protein phosphatase 2A - Xing_2008_Cell_133_154
Author(s) : Xing Y , Li Z , Chen Y , Stock JB , Jeffrey PD , Shi Y
Ref : Cell , 133 :154 , 2008
PubMedID: 18394995
Gene_locus related to this paper: human-PPME1

Title : Spatial control of protein phosphatase 2A (de)methylation - Longin_2008_Exp.Cell.Res_314_68
Author(s) : Longin S , Zwaenepoel K , Martens E , Louis JV , Rondelez E , Goris J , Janssens V
Ref : Experimental Cell Research , 314 :68 , 2008
PubMedID: 17803990
Gene_locus related to this paper: human-PPME1

Title : Generation of active protein phosphatase 2A is coupled to holoenzyme assembly - Hombauer_2007_PLoS.Biol_5_e155
Author(s) : Hombauer H , Weismann D , Mudrak I , Stanzel C , Fellner T , Lackner DH , Ogris E
Ref : PLoS Biol , 5 :e155 , 2007
PubMedID: 17550305
Gene_locus related to this paper: human-PPME1

Title : Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55\/B) - Ikehara_2007_Biochem.Biophys.Res.Commun_354_1052
Author(s) : Ikehara T , Ikehara S , Imamura S , Shinjo F , Yasumoto T
Ref : Biochemical & Biophysical Research Communications , 354 :1052 , 2007
PubMedID: 17274953
Gene_locus related to this paper: human-PPME1

Title : Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits - Tolstykh_2000_EMBO.J_19_5682
Author(s) : Tolstykh T , Lee J , Vafai S , Stock JB
Ref : EMBO Journal , 19 :5682 , 2000
PubMedID: 11060019
Gene_locus related to this paper: human-PPME1

Title : A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A - Ogris_1999_J.Biol.Chem_274_14382
Author(s) : Ogris E , Du X , Nelson KC , Mak EK , Yu XX , Lane WS , Pallas DC
Ref : Journal of Biological Chemistry , 274 :14382 , 1999
PubMedID: 10318862
Gene_locus related to this paper: human-PPME1 , mouse-PPME1

Title : A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain - Lee_1996_Proc.Natl.Acad.Sci.U.S.A_93_6043
Author(s) : Lee J , Chen Y , Tolstykh T , Stock J
Ref : Proc Natl Acad Sci U S A , 93 :6043 , 1996
PubMedID: 8650216
Gene_locus related to this paper: human-PPME1