Yeary_1984_Am.J.Vet.Res_45_288

Six Beagle dogs were orally intubated with mixtures of a urea-based fertilizer, 2,4-D, mecoprop (MCPP), dicamba, and either bensulide or chlorpyrifos. The mixtures were formulated as they are used in liquid application to lawns. The dogs were given volumes of 10 ml/kg of body weight, delivering the following quantities of each ingredient: urea--623 mg/kg, inorganic phosphorus (P2O5)--24 mg/kg, potassium (K2O)--66 mg/kg, 2,4-D--6.5 mg/kg, MCPP--3.26 mg/kg, dicamba--0.55 mg/kg, and either bensulide--60.93 mg/kg or chlorpyrifos--6.77 mg/kg. The dogs were given 3 consecutive daily doses of the mixture containing bensulide (round 1) or the mixture containing chlorpyrifos (round 2). The dogs did not exhibit any clinical signs of illness associated with the treatments. Effects on hematologic values or routine clinical chemical analyses did not occur with the round 2 mixture. Serum lactic dehydrogenase activity decreased by approximately 50% after a single dose of the round 1 mixture was given. Plasma cholinesterase decreased to approximately 50% of control values following either the round 1 or the round 2 mixture; this decrease was not accompanied by cholinergic signs of intoxication.