| Title : Chemical screening of an inhibitor for gibberellin receptors based on a yeast two-hybrid system - Yoon_2013_Bioorg.Med.Chem.Lett_23_1096 |
| Author(s) : Yoon JM , Nakajima M , Mashiguchi K , Park SH , Otani M , Asami T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :1096 , 2013 |
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Abstract :
We applied a yeast two-hybrid (Y2H) system to the high-throughput monitoring of two proteins' interaction, a receptor for phytohormone gibberellin (GA) and its direct signal transducer DELLA. With this system, we screened inhibitors to the interaction. As a result, we discovered a chemical, 3-(2-thienylsulfonyl)pyrazine-2-carbonitrile (TSPC), and we confirmed that TSPC is an inhibitor for GA perception by in vitro and in planta evaluations. |
| PubMedSearch : Yoon_2013_Bioorg.Med.Chem.Lett_23_1096 |
| PubMedID: 23298808 |
Yoon JM, Nakajima M, Mashiguchi K, Park SH, Otani M, Asami T (2013)
Chemical screening of an inhibitor for gibberellin receptors based on a yeast two-hybrid system
Bioorganic & Medicinal Chemistry Lett
23 :1096
Yoon JM, Nakajima M, Mashiguchi K, Park SH, Otani M, Asami T (2013)
Bioorganic & Medicinal Chemistry Lett
23 :1096