| Title : Anti-arthritic effects of polyunsaturated fatty acid rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model - Yoshida_2025_Mod.Rheumatol__ |
| Author(s) : Yoshida A , Murakami K , Tsukamoto H , Hotta Y , Nakayama Y , Saito R , Shirakashi M , Tsuji H , Hiwa R , Akizuki S , Nakashima R , Yoshifuji H , Onishi A , Tanaka M , Mimori T , Morinobu A |
| Ref : Mod Rheumatol , : , 2025 |
|
Abstract :
OBJECTIVES: Polyunsaturated fatty acids (PUFAs) are healthy fats that contain a double carbon bond. They are made up of omega (omega)-3 and omega-6 PUFAs, where omega-3 PUFAs exhibit beneficial effects, such as the suppression of cardiovascular events and the improvement of abnormal lipid metabolism. Though, their effects on rheumatoid arthritis (RA) are unclear. Epoxy fatty acids (EpFAs), which are intermediate metabolites of omega-6 and omega-3 PUFAs, are formed through the action of cytochrome P and possess anti-inflammatory properties. However, they are quickly converted into their inactive forms by soluble epoxide hydrolase (sEH). METHODS: The protective effects of omega-3 and omega-6 PUFAs on arthritic symptoms with or without sEH inhibitors (sEHi) were investigated in a collagen-induced arthritis mouse model. RESULTS: The group treated with a combination of omega-3 PUFAs and sEHi showed a marked inhibition of arthritis compared to the other groups. Analysis of the faecal flora before the onset of arthritis showed an inverse correlation between the arthritis score and the relative abundance of Lactococcus, suggesting that changes in the intestinal flora in the preclinical stage may influence the onset of arthritis. CONCLUSIONS: This study highlights the potential of omega-3 PUFAs combined with sEHi as novel protective effect for RA. |
| PubMedSearch : Yoshida_2025_Mod.Rheumatol__ |
| PubMedID: 40048675 |
Yoshida A, Murakami K, Tsukamoto H, Hotta Y, Nakayama Y, Saito R, Shirakashi M, Tsuji H, Hiwa R, Akizuki S, Nakashima R, Yoshifuji H, Onishi A, Tanaka M, Mimori T, Morinobu A (2025)
Anti-arthritic effects of polyunsaturated fatty acid rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model
Mod Rheumatol
:
Yoshida A, Murakami K, Tsukamoto H, Hotta Y, Nakayama Y, Saito R, Shirakashi M, Tsuji H, Hiwa R, Akizuki S, Nakashima R, Yoshifuji H, Onishi A, Tanaka M, Mimori T, Morinobu A (2025)
Mod Rheumatol
: