| Title : N-methoxy-beta-carboline alkaloids with inhibitory activities against Abeta42 aggregation and acetylcholinesterase from the stems of Picrasma quassioides - Zhang_2020_Bioorg.Chem_101_104043 |
| Author(s) : Zhang J , Zhao SS , Xie J , Yang J , Chen GD , Hu D , Zhang WG , Wang CX , Yao XS , Gao H |
| Ref : Bioorg Chem , 101 :104043 , 2020 |
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Abstract :
Nine new N-methoxy-beta-carboline alkaloids (NMCAs) (1a/1b-3a/3b and 4-6) and two known NMCAs (7 and 8) were isolated from the stems of Picrasma quassioides. Their structures were elucidated by spectroscopic data analyses, quantum chemical calculations, and single-crystal X-ray crystallographic data. An analysis of the (13)C NMR chemical shifts of the N-methoxy groups in these NMCAs and 41 gathered known compounds reveals the phenomenon that the chemical shifts of all these N-methoxy groups are greater than deltaC 62, which can be used to recognize the N-methoxy group rapidly. In addition, the acetylcholinesterase (AChE) and Abeta42 aggregation inhibitory activities of 1-8 were evaluated. Compounds 1, 2, 7, and 8 displayed AChE inhibitory activity with IC50 values of 14.9, 13.2, 17.6, and 43.9 muM, respectively. Compound 2 showed inhibition activity against Abeta42 aggregation with an IC50 value of 10.1 muM. |
| PubMedSearch : Zhang_2020_Bioorg.Chem_101_104043 |
| PubMedID: 32629286 |
Zhang J, Zhao SS, Xie J, Yang J, Chen GD, Hu D, Zhang WG, Wang CX, Yao XS, Gao H (2020)
N-methoxy-beta-carboline alkaloids with inhibitory activities against Abeta42 aggregation and acetylcholinesterase from the stems of Picrasma quassioides
Bioorg Chem
101 :104043
Zhang J, Zhao SS, Xie J, Yang J, Chen GD, Hu D, Zhang WG, Wang CX, Yao XS, Gao H (2020)
Bioorg Chem
101 :104043