| Title : Protein domain of unknown function DUF1023 is an alpha\/beta hydrolase - Zheng_2005_Proteins_59_1 |
| Author(s) : Zheng M , Ginalski K , Rychlewski L , Grishin NV |
| Ref : Proteins , 59 :1 , 2005 |
| Abstract : Pfam family DUF1023 consists entirely of uncharacterized proteins generated by sequencing the genomes of Actinobacteria (Bateman A., et al., Nucleic Acids Res. 2004;32 Database issue:D138-141.) Utilizing sequence similarity detection methods, we infer homology between DUF1023 and alpha/beta hydrolases. DUF1023 proteins conserve the core secondary structures in alpha/beta hydrolase fold, and share similar catalytic machinery as that of alpha/beta hydrolases. We predict DUF1023 spatial structure and deduce that they function as hydrolases utilizing catalytic Ser-His-Asp triad with the serine as a nucleophile. |
| ESTHER : Zheng_2005_Proteins_59_1 |
| PubMedSearch : Zheng_2005_Proteins_59_1 |
| PubMedID: 15688435 |
Zheng M, Ginalski K, Rychlewski L, Grishin NV (2005)
Protein domain of unknown function DUF1023 is an alpha\/beta hydrolase
Proteins
59 :1
Zheng M, Ginalski K, Rychlewski L, Grishin NV (2005)
Proteins
59 :1