| Title : Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy - Zheng_2009_J.Med.Chem_52_4095 |
| Author(s) : Zheng H , Youdim MB , Fridkin M |
| Ref : Journal of Medicinal Chemistry , 52 :4095 , 2009 |
|
Abstract :
A novel strategy to develop site-activated multifunctional chelators for targeting multiple etiologies of Alzheimer's disease is reported. The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. |
| PubMedSearch : Zheng_2009_J.Med.Chem_52_4095 |
| PubMedID: 19485411 |
Zheng H, Youdim MB, Fridkin M (2009)
Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy
Journal of Medicinal Chemistry
52 :4095
Zheng H, Youdim MB, Fridkin M (2009)
Journal of Medicinal Chemistry
52 :4095