Youdim MB

General

Full name : Youdim Moussa BH

First name : Moussa BH

Mail : Technion-Israel Institute of Technology, Haifa

Zip Code :

City :

Country : Israel

Email : youdim@tx.technion.ac.il

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References (46)

Title : A novel neuroprotective cholinesterase-monoamine oxidase inhibitor for treatment of dementia and depression in Parkinson's disease - Liu_2022_Ageing.Neurodegener.Dis__
Author(s) : Liu W , Wang Y , Youdim MB
Ref : Ageing and Neurodegenerative Diseases , : , 2022
Abstract :
PubMedSearch : Liu_2022_Ageing.Neurodegener.Dis__
PubMedID:

Title : Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE\/BuChE inhibitor in scopolamine mouse model and inflammatory cells - Liu_2017_Neuropharmacol_113_445
Author(s) : Liu W , Rabinovich A , Nash Y , Frenkel D , Wang Y , Youdim MB , Weinreb O
Ref : Neuropharmacology , 113 :445 , 2017
Abstract :
PubMedSearch : Liu_2017_Neuropharmacol_113_445
PubMedID: 27984078

Title : Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease - Liu_2016_Neuropharmacol_109_376
Author(s) : Liu W , Lang M , Youdim MB , Amit T , Sun Y , Zhang Z , Wang Y , Weinreb O
Ref : Neuropharmacology , 109 :376 , 2016
Abstract :
PubMedSearch : Liu_2016_Neuropharmacol_109_376
PubMedID: 27318273

Title : Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease - Unzeta_2016_Front.Neurosci_10_205
Author(s) : Unzeta M , Esteban G , Bolea I , Fogel WA , Ramsay RR , Youdim MB , Tipton KF , Marco-Contelles J
Ref : Front Neurosci , 10 :205 , 2016
Abstract :
PubMedSearch : Unzeta_2016_Front.Neurosci_10_205
PubMedID: 27252617

Title : Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and beta-amyloid in ageing and Alzheimer's disease - Weinreb_2016_Br.J.Pharmacol_173_2080
Author(s) : Weinreb O , Amit T , Bar-Am O , Youdim MB
Ref : British Journal of Pharmacology , 173 :2080 , 2016
Abstract :
PubMedSearch : Weinreb_2016_Br.J.Pharmacol_173_2080
PubMedID: 26332830

Title : DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline - Trudler_2014_J.Neurochem_129_434
Author(s) : Trudler D , Weinreb O , Mandel SA , Youdim MB , Frenkel D
Ref : Journal of Neurochemistry , 129 :434 , 2014
Abstract :
PubMedSearch : Trudler_2014_J.Neurochem_129_434
PubMedID: 24355073

Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543
Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M
Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014
Abstract :
PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543
PubMedID: 24813882

Title : Novel chelators targeting cell cycle arrest, acetylcholinesterase, and monoamine oxidase for Alzheimer's therapy - Zheng_2012_Curr.Drug.Targets_13_1089
Author(s) : Zheng H , Fridkin M , Youdim MB
Ref : Curr Drug Targets , 13 :1089 , 2012
Abstract :
PubMedSearch : Zheng_2012_Curr.Drug.Targets_13_1089
PubMedID: 22676912

Title : From antioxidant chelators to site-activated multi-target chelators targeting hypoxia inducing factor, beta-amyloid, acetylcholinesterase and monoamine oxidase A\/B - Zheng_2012_Mini.Rev.Med.Chem_12_364
Author(s) : Zheng H , Fridkin M , Youdim MB
Ref : Mini Rev Med Chem , 12 :364 , 2012
Abstract :
PubMedSearch : Zheng_2012_Mini.Rev.Med.Chem_12_364
PubMedID: 22303968

Title : Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment - Weinreb_2012_Curr.Drug.Targets_13_483
Author(s) : Weinreb O , Amit T , Bar-Am O , Youdim MB
Ref : Curr Drug Targets , 13 :483 , 2012
Abstract :
PubMedSearch : Weinreb_2012_Curr.Drug.Targets_13_483
PubMedID: 22280345

Title : From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease - Zheng_2012_J.Alzheimers.Dis_30_1
Author(s) : Zheng H , Amit T , Bar-Am O , Fridkin M , Youdim MB , Mandel SA
Ref : J Alzheimers Dis , 30 :1 , 2012
Abstract :
PubMedSearch : Zheng_2012_J.Alzheimers.Dis_30_1
PubMedID: 22387411

Title : A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor - Weinreb_2011_Int.Rev.Neurobiol_100_191
Author(s) : Weinreb O , Amit T , Bar-Am O , Youdim MB
Ref : International Review of Neurobiology , 100 :191 , 2011
Abstract :
PubMedSearch : Weinreb_2011_Int.Rev.Neurobiol_100_191
PubMedID: 21971009

Title : Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation - Bar-Am_2010_J.Alzheimers.Dis_21_361
Author(s) : Bar-Am O , Amit T , Weinreb O , Youdim MB , Mandel S
Ref : J Alzheimers Dis , 21 :361 , 2010
Abstract :
PubMedSearch : Bar-Am_2010_J.Alzheimers.Dis_21_361
PubMedID: 20555137

Title : Site-activated chelators derived from anti-Parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease - Zheng_2010_Neurochem.Res_35_2117
Author(s) : Zheng H , Fridkin M , Youdim MB
Ref : Neurochem Res , 35 :2117 , 2010
Abstract :
PubMedSearch : Zheng_2010_Neurochem.Res_35_2117
PubMedID: 20981484

Title : Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy - Zheng_2010_ACS.Chem.Biol_5_603
Author(s) : Zheng H , Youdim MB , Fridkin M
Ref : ACS Chemical Biology , 5 :603 , 2010
Abstract :
PubMedSearch : Zheng_2010_ACS.Chem.Biol_5_603
PubMedID: 20455574

Title : Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy - Zheng_2009_J.Med.Chem_52_4095
Author(s) : Zheng H , Youdim MB , Fridkin M
Ref : Journal of Medicinal Chemistry , 52 :4095 , 2009
Abstract :
PubMedSearch : Zheng_2009_J.Med.Chem_52_4095
PubMedID: 19485411

Title : The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats - Bar-Am_2009_J.Mol.Neurosci_37_135
Author(s) : Bar-Am O , Weinreb O , Amit T , Youdim MB
Ref : Journal of Molecular Neuroscience , 37 :135 , 2009
Abstract :
PubMedSearch : Bar-Am_2009_J.Mol.Neurosci_37_135
PubMedID: 18751929

Title : Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs - Weinreb_2009_Neurotherapeutics_6_163
Author(s) : Weinreb O , Mandel S , Bar-Am O , Yogev-Falach M , Avramovich-Tirosh Y , Amit T , Youdim MB
Ref : Neurotherapeutics , 6 :163 , 2009
Abstract :
PubMedSearch : Weinreb_2009_Neurotherapeutics_6_163
PubMedID: 19110207

Title : The neuroprotective mechanism of action of the multimodal drug ladostigil - Weinreb_2008_Front.Biosci_13_5131
Author(s) : Weinreb O , Amit T , Bar-Am O , Yogev-Falach M , Youdim MB
Ref : Front Biosci , 13 :5131 , 2008
Abstract :
PubMedSearch : Weinreb_2008_Front.Biosci_13_5131
PubMedID: 18508575

Title : The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity - Weinreb_2008_Chem.Biol.Interact_175_318
Author(s) : Weinreb O , Bar-Am O , Amit T , Drigues N , Sagi Y , Youdim MB
Ref : Chemico-Biological Interactions , 175 :318 , 2008
Abstract :
PubMedSearch : Weinreb_2008_Chem.Biol.Interact_175_318
PubMedID: 18598687

Title : Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro - Bar-Am_2007_J.Neurochem_103_500
Author(s) : Bar-Am O , Amit T , Youdim MB
Ref : Journal of Neurochemistry , 103 :500 , 2007
Abstract :
PubMedSearch : Bar-Am_2007_J.Neurochem_103_500
PubMedID: 17635668

Title : A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing - Yogev-Falach_2006_FASEB.J_20_2177
Author(s) : Yogev-Falach M , Bar-Am O , Amit T , Weinreb O , Youdim MB
Ref : FASEB Journal , 20 :2177 , 2006
Abstract :
PubMedSearch : Yogev-Falach_2006_FASEB.J_20_2177
PubMedID: 16935943

Title : Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs\; ladostigil - Youdim_2006_Neurotox.Res_10_181
Author(s) : Youdim MB , Amit T , Bar-Am O , Weinreb O , Yogev-Falach M
Ref : Neurotox Res , 10 :181 , 2006
Abstract :
PubMedSearch : Youdim_2006_Neurotox.Res_10_181
PubMedID: 17197368

Title : The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30 - Youdim_2006_Curr.Alzheimer.Res_3_541
Author(s) : Youdim MB
Ref : Curr Alzheimer Res , 3 :541 , 2006
Abstract :
PubMedSearch : Youdim_2006_Curr.Alzheimer.Res_3_541
PubMedID: 17168653

Title : Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition - Youdim_2005_J.Neurosci.Res_79_172
Author(s) : Youdim MB , Bar Am O , Yogev-Falach M , Weinreb O , Maruyama W , Naoi M , Amit T
Ref : Journal of Neuroscience Research , 79 :172 , 2005
Abstract :
PubMedSearch : Youdim_2005_J.Neurosci.Res_79_172
PubMedID: 15573406

Title : The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats - Sagi_2005_Br.J.Pharmacol_146_553
Author(s) : Sagi Y , Drigues N , Youdim MB
Ref : British Journal of Pharmacology , 146 :553 , 2005
Abstract :
PubMedSearch : Sagi_2005_Br.J.Pharmacol_146_553
PubMedID: 16086033

Title : Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases - Youdim_2005_Mech.Ageing.Dev_126_317
Author(s) : Youdim MB , Fridkin M , Zheng H
Ref : Mech Ageing Dev , 126 :317 , 2005
Abstract :
PubMedSearch : Youdim_2005_Mech.Ageing.Dev_126_317
PubMedID: 15621213

Title : Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders - Youdim_2005_Trends.Pharmacol.Sci_26_27
Author(s) : Youdim MB , Buccafusco JJ
Ref : Trends in Pharmacological Sciences , 26 :27 , 2005
Abstract :
PubMedSearch : Youdim_2005_Trends.Pharmacol.Sci_26_27
PubMedID: 15629202

Title : CNS Targets for multi-functional drugs in the treatment of Alzheimer's and Parkinson's diseases - Youdim_2005_J.Neural.Transm.(Vienna)_112_519
Author(s) : Youdim MB , Buccafusco JJ
Ref : J Neural Transm (Vienna) , 112 :519 , 2005
Abstract :
PubMedSearch : Youdim_2005_J.Neural.Transm.(Vienna)_112_519
PubMedID: 15666041

Title : Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation - Youdim_2004_Neurotoxicol_25_243
Author(s) : Youdim MB , Weinstock M
Ref : Neurotoxicology , 25 :243 , 2004
Abstract :
PubMedSearch : Youdim_2004_Neurotoxicol_25_243
PubMedID: 14697899

Title : PKC and MAP kinase-dependent processing of amyloid precursor protein (APP) by neuroprotective propargylamine cholinesterase inhibitors derived from rasagiline and nonsteroidal anti-inflammatory drugs. -
Author(s) : Youdim MB , Amit T , Avramovich Y , Bar-Am O , Weinstock M , Yogev-Falach M
Ref : Cholinergic Mechanisms, CRC Press :353 , 2004
PubMedID:

Title : Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo - Bar-Am_2004_J.Neurochem_89_1119
Author(s) : Bar-Am O , Yogev-Falach M , Amit T , Sagi Y , Youdim MB
Ref : Journal of Neurochemistry , 89 :1119 , 2004
Abstract :
PubMedSearch : Bar-Am_2004_J.Neurochem_89_1119
PubMedID: 15147504

Title : Poster (57) A novel neuroprotective trifunctional cholinesterase inhibitor derivative of the antiparkinson drug, rasagiline, for treatment of dementia and lewy body disease co-morbid with depression -
Author(s) : Youdim MB , Sagi Y , Derigus N , Naoi M , Maruyama W , Amit T , Falash-Yogev M , Weinstock M
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :351 , 2004
PubMedID:

Title : Amyloid Processing and Signal Transduction Properties of Antiparkinson-Antialzheimer Neuroprotective Drugs Rasagiline and TV3326 - Youdim_2003_Ann.N.Y.Acad.Sci_993_378
Author(s) : Youdim MB , Amit T , Bar-Am O , Weinstock M , Yogev-Falach M
Ref : Annals of the New York Academy of Sciences , 993 :378 , 2003
Abstract :
PubMedSearch : Youdim_2003_Ann.N.Y.Acad.Sci_993_378
PubMedID: 12853332

Title : Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor - Maruyama_2003_Neurosci.Lett_341_233
Author(s) : Maruyama W , Weinstock M , Youdim MB , Nagai M , Naoi M
Ref : Neuroscience Letters , 341 :233 , 2003
Abstract :
PubMedSearch : Maruyama_2003_Neurosci.Lett_341_233
PubMedID: 12697291

Title : Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor - Sagi_2003_J.Neurochem_86_290
Author(s) : Sagi Y , Weinstock M , Youdim MB
Ref : Journal of Neurochemistry , 86 :290 , 2003
Abstract :
PubMedSearch : Sagi_2003_J.Neurochem_86_290
PubMedID: 12871570

Title : A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease - Weinstock_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_555
Author(s) : Weinstock M , Gorodetsky E , Poltyrev T , Gross A , Sagi Y , Youdim MB
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 27 :555 , 2003
Abstract :
PubMedSearch : Weinstock_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_555
PubMedID: 12787840

Title : Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline - Youdim_2002_Mech.Ageing.Dev_123_1081
Author(s) : Youdim MB , Weinstock M
Ref : Mech Ageing Dev , 123 :1081 , 2002
Abstract :
PubMedSearch : Youdim_2002_Mech.Ageing.Dev_123_1081
PubMedID: 12044957

Title : Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression - Weinstock_2002_Psychopharmacology.(Berl)_160_318
Author(s) : Weinstock M , Poltyrev T , Bejar C , Youdim MB
Ref : Psychopharmacology (Berl) , 160 :318 , 2002
Abstract :
PubMedSearch : Weinstock_2002_Psychopharmacology.(Berl)_160_318
PubMedID: 11889501

Title : The involvement of mitogen-activated protein (MAP) kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline - Yogev-Falach_2002_Faseb.J_16_1674
Author(s) : Yogev-Falach M , Amit T , Bar-Am O , Weinstock M , Youdim MB
Ref : FASEB Journal , 16 :1674 , 2002
Abstract :
PubMedSearch : Yogev-Falach_2002_Faseb.J_16_1674
PubMedID: 12206996

Title : Limited potentiation of blood pressure response to oral tyramine by brain-selective monoamine oxidase A-B inhibitor, TV-3326 in conscious rabbits(1) - Weinstock_2002_Neuropharmacol_43_999
Author(s) : Weinstock M , Gorodetsky E , Wang RH , Gross A , Weinreb O , Youdim MB
Ref : Neuropharmacology , 43 :999 , 2002
Abstract :
PubMedSearch : Weinstock_2002_Neuropharmacol_43_999
PubMedID: 12423669

Title : Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate] - Youdim_2001_Cell.Mol.Neurobiol_21_555
Author(s) : Youdim MB , Weinstock M
Ref : Cellular Molecular Neurobiology , 21 :555 , 2001
Abstract :
PubMedSearch : Youdim_2001_Cell.Mol.Neurobiol_21_555
PubMedID: 12043833

Title : Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs - Weinstock_2001_Ann.N.Y.Acad.Sci_939_148
Author(s) : Weinstock M , Kirschbaum-Slager N , Lazarovici P , Bejar C , Youdim MB , Shoham S
Ref : Annals of the New York Academy of Sciences , 939 :148 , 2001
Abstract :
PubMedSearch : Weinstock_2001_Ann.N.Y.Acad.Sci_939_148
PubMedID: 11462767

Title : The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo - Youdim_2001_Ann.N.Y.Acad.Sci_939_450
Author(s) : Youdim MB , Wadia A , Tatton W , Weinstock M
Ref : Annals of the New York Academy of Sciences , 939 :450 , 2001
Abstract :
PubMedSearch : Youdim_2001_Ann.N.Y.Acad.Sci_939_450
PubMedID: 11462801

Title : TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease - Weinstock_2000_J.Neural.Transm.Suppl__157
Author(s) : Weinstock M , Bejar C , Wang RH , Poltyrev T , Gross A , Finberg JP , Youdim MB
Ref : J Neural Transm Suppl , :157 , 2000
Abstract :
PubMedSearch : Weinstock_2000_J.Neural.Transm.Suppl__157
PubMedID: 11205137

Title : Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells - Paul_1993_Faseb.J_7_1171
Author(s) : Paul IA , Basile AS , Rojas E , Youdim MB , De Costa B , Skolnick P , Pollard HB , Kuijpers GA
Ref : FASEB Journal , 7 :1171 , 1993
Abstract :
PubMedSearch : Paul_1993_Faseb.J_7_1171
PubMedID: 8375616