Zhu_2019_Front.Pharmacol_10_258

Reference

Title : Jia-Wei-Kai-Xin-San, an Herbal Medicine Formula, Ameliorates Cognitive Deficits via Modulating Metabolism of Beta Amyloid Protein and Neurotrophic Factors in Hippocampus of Abeta1-42 Induced Cognitive Deficit Mice - Zhu_2019_Front.Pharmacol_10_258
Author(s) : Zhu Y , Shi Y , Cao C , Han Z , Liu M , Qi M , Huang R , Zhu Z , Qian D , Duan JA
Ref : Front Pharmacol , 10 :258 , 2019
Abstract :

Jia-Wei-Kai-Xin-San (JWKXS) is a Chinese medicine formula applied for treating morbid forgetfulness in ancient China. Today, this formula is frequently applied for Alzheimer's disease and vascular dementia (VD) in clinic. Here, we developed it as granules and aimed to evaluate its anti-AD effect on beta amyloid protein 1-42 (Abeta1-42) induced cognitive deficit mice and reveal the possible molecular mechanisms. Firstly, daily intra-gastric administration of chemically standardized of JWKXS granules for 7 days significantly ameliorated the cognitive deficit symptoms and inhibited cell apoptosis in hippocampus on Abeta1-42 injection mice. JWKXS granules significantly decreased Abeta level, increased superoxide dismutase activity and decreased malondialdehyde level in hippocampus of model mice. It also restored acetylcholine amounts, inhibited acetylcholinesterase activities and increased choline acetyltransferase activities. In addition, JWKXS granules enabled the transformation of precursors of NGF and BDNF into mature forms. Furthermore, JWKXS granules could regulate gene expressions related to Abeta production, transportation, degradation and neurotrophic factor transformation, which led to down-regulation of Abeta and up-regulation of NGF and BDNF. These findings suggested that JWKXS granules ameliorated cognitive deficit via decreasing Abeta levels, protecting neuron from oxidation damages and nourishing neuron, which could serve as alternative medicine for patients suffering from AD.

PubMedSearch : Zhu_2019_Front.Pharmacol_10_258
PubMedID: 30941041

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Citations formats

Zhu Y, Shi Y, Cao C, Han Z, Liu M, Qi M, Huang R, Zhu Z, Qian D, Duan JA (2019)
Jia-Wei-Kai-Xin-San, an Herbal Medicine Formula, Ameliorates Cognitive Deficits via Modulating Metabolism of Beta Amyloid Protein and Neurotrophic Factors in Hippocampus of Abeta1-42 Induced Cognitive Deficit Mice
Front Pharmacol 10 :258

Zhu Y, Shi Y, Cao C, Han Z, Liu M, Qi M, Huang R, Zhu Z, Qian D, Duan JA (2019)
Front Pharmacol 10 :258