Zivkovic_2017_Chem.Biodivers_14_

Reference

Title : Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg - Zivkovic_2017_Chem.Biodivers_14_
Author(s) : Zivkovic JC , Barreira JCM , Savikin KP , Alimpic AZ , Stojkovic DS , Dias MI , Santos-Buelga C , Duletic-Lausevic SN , Ferreira I
Ref : Chem Biodivers , 14 : , 2017
Abstract :

Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6'''-O-acetyl)-beta-allosyl (1'''-->2''')-beta-glucoside were the major phenolics in V. teucrium. Additionally, the antineurodegenerative activity was tested at concentrations of 25, 50, and 100 mug/ml using acetylcholinesterase (AChE) and tyrosinase (TYR) assays. The inhibition of both enzymes was achieved with the investigated extracts, ranging from 22.78 to 35.40% for AChE and from 9.57 to 16.38% for TYR. There was no statistical difference between the activities of the analyzed extracts. Our data indicate that V. teucrium and V. jacquinii may have beneficial effects against Alzheimer's and Parkinson's disease.

PubMedSearch : Zivkovic_2017_Chem.Biodivers_14_
PubMedID: 28488389

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Citations formats

Zivkovic JC, Barreira JCM, Savikin KP, Alimpic AZ, Stojkovic DS, Dias MI, Santos-Buelga C, Duletic-Lausevic SN, Ferreira I (2017)
Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg
Chem Biodivers 14 :

Zivkovic JC, Barreira JCM, Savikin KP, Alimpic AZ, Stojkovic DS, Dias MI, Santos-Buelga C, Duletic-Lausevic SN, Ferreira I (2017)
Chem Biodivers 14 :