| Title : Donepezil restores GH secretion in old rats without affecting the sleep\/wake cycle - Zizzari_2006_Neurobiol.Aging_27_784 e1 |
| Author(s) : Zizzari P , Bassant MH , Poindessous-Jazat F , Epelbaum J , Bluet-Pajot MT |
| Ref : Neurobiology of Aging , 27 :784 e1 , 2006 |
|
Abstract :
A chronic treatment with a cholinesterase inhibitor, donepezil (0.085 mg/kg/h for 30 days) increases significantly the number and amplitude of growth hormone (GH) pulses in 3- and 24-month-old rats without modifying nadir GH values. This treatment does not reduce age-related alterations in sleep/wake cycle but it increases immobility-related high-voltage spindles (HVS) in old animals. These data suggest that cholinergic mechanisms involved in age-related alterations in GH and sleep regulation are different. |
| PubMedSearch : Zizzari_2006_Neurobiol.Aging_27_784 e1 |
| PubMedID: 16199109 |
Zizzari P, Bassant MH, Poindessous-Jazat F, Epelbaum J, Bluet-Pajot MT (2006)
Donepezil restores GH secretion in old rats without affecting the sleep\/wake cycle
Neurobiology of Aging
27 :784 e1
Zizzari P, Bassant MH, Poindessous-Jazat F, Epelbaum J, Bluet-Pajot MT (2006)
Neurobiology of Aging
27 :784 e1