de la Escalera_1990_EMBO.J_9_3593

Reference

Title : Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases - de la Escalera_1990_EMBO.J_9_3593
Author(s) : de la Escalera S , Bockamp EO , Moya F , Piovant M , Jimenez F
Ref : EMBO Journal , 9 :3593 , 1990
Abstract :

Monoclonal antibodies have served to characterize neurotactin, a novel Drosophila protein for which a role in cell adhesion is postulated. Neurotactin is a transmembrane protein, as indicated by epitope mapping and amino acid sequence. Similarly to other cell adhesion molecules, neurotactin accumulates in parts of the membrane where neurotactin-expressing cells contact each other. The protein is only detected during cell proliferation and differentiation, and it is found mainly in neural tissue and also in mesoderm and imaginal discs. Neurotactin has a large cytoplasmic domain rich in charged residues and an extracellular domain similar to cholinesterase that lacks the active site serine required for esterase activity. The extracellular domain also contains three copies of the tripeptide leucine-arginine-glutamate, a motif that forms the primary sequence of the adhesive site of vertebrate s-laminin.

PubMedSearch : de la Escalera_1990_EMBO.J_9_3593
PubMedID: 2120047
Gene_locus related to this paper: drome-nrtac

Related information

Gene_locus drome-nrtac
Family drome-nrtac    Neurotactin    Non-catalytic_C

Citations formats

de la Escalera S, Bockamp EO, Moya F, Piovant M, Jimenez F (1990)
Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases
EMBO Journal 9 :3593

de la Escalera S, Bockamp EO, Moya F, Piovant M, Jimenez F (1990)
EMBO Journal 9 :3593