van den Berg_2008_Nat.Biotechnol_26_1161

Reference

Title : Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum - van den Berg_2008_Nat.Biotechnol_26_1161
Author(s) : van den Berg MA , Albang R , Albermann K , Badger JH , Daran JM , Driessen AJ , Garcia-Estrada C , Fedorova ND , Harris DM , Heijne WH , Joardar V , Kiel JA , Kovalchuk A , Martin JF , Nierman WC , Nijland JG , Pronk JT , Roubos JA , van der Klei IJ , van Peij NN , Veenhuis M , von Dohren H , Wagner C , Wortman J , Bovenberg RA
Ref : Nat Biotechnol , 26 :1161 , 2008
Abstract :

Industrial penicillin production with the filamentous fungus Penicillium chrysogenum is based on an unprecedented effort in microbial strain improvement. To gain more insight into penicillin synthesis, we sequenced the 32.19 Mb genome of P. chrysogenum Wisconsin54-1255 and identified numerous genes responsible for key steps in penicillin production. DNA microarrays were used to compare the transcriptomes of the sequenced strain and a penicillinG high-producing strain, grown in the presence and absence of the side-chain precursor phenylacetic acid. Transcription of genes involved in biosynthesis of valine, cysteine and alpha-aminoadipic acid-precursors for penicillin biosynthesis-as well as of genes encoding microbody proteins, was increased in the high-producing strain. Some gene products were shown to be directly controlling beta-lactam output. Many key cellular transport processes involving penicillins and intermediates remain to be characterized at the molecular level. Genes predicted to encode transporters were strongly overrepresented among the genes transcriptionally upregulated under conditions that stimulate penicillinG production, illustrating potential for future genomics-driven metabolic engineering.

PubMedSearch : van den Berg_2008_Nat.Biotechnol_26_1161
PubMedID: 18820685
Gene_locus related to this paper: pench-b6gw01 , pench-b6gwp9 , pench-b6gzt9 , pench-b6h2r5 , pench-b6h3c6 , pench-b6h3s3 , pench-b6h6w7 , pench-b6h7m0 , pench-b6h043 , pench-b6h270 , pench-b6h303 , pench-b6hcx0 , pench-b6hfx1 , pench-b6hjt6 , pench-b6hm64 , pench-b6hmg2 , pench-b6hnf2 , pench-b6hnf7 , pench-b6hph0 , pench-b6huc9 , penrw-b6hdc6 , pench-q3v6c9 , pencw-atg15 , pencw-b6gwt5 , pencw-b6gx34 , pencw-b6gzd8 , pencw-b6gzp7 , pencw-b6h2f4 , pencw-b6h2h0 , pencw-b6h2n4 , pencw-b6h3u7 , pencw-b6h4n3 , pencw-b6h4s6 , pencw-b6h5k2 , pencw-b6h6t6 , pencw-b6h7f0 , pencw-b6h7r1 , pencw-b6h8a0 , pencw-b6h8i1 , pencw-b6h828 , pencw-b6ha41 , pencw-b6hat0 , pencw-b6hb79 , pencw-b6hcq8 , pencw-b6hfx7 , pencw-b6hgb0 , pencw-b6hhg8 , pencw-b6hjj1 , pencw-b6hl02 , pencw-b6hmd9 , pencw-b6hmh5 , pencw-b6hmh7 , pencw-b6hpn2 , pencw-b6hpz6 , pencw-b6hqu4 , pencw-b6hs49 , pencw-b6hun6 , pencw-b6hv09 , pencw-cuti1 , pencw-cuti2 , pencw-dapb , pencw-b6had0 , pencw-b6h497 , pencw-b6gw76 , pencw-b6hs05 , pencw-b6h0h6 , penna-a0a1v6yep8 , penrw-b6huu8 , penrw-kex1 , penrw-cbpya , penrw-adrd

Related information

Gene_locus pench-b6gw01    pench-b6gwp9    pench-b6gzt9    pench-b6h2r5    pench-b6h3c6    pench-b6h3s3    pench-b6h6w7    pench-b6h7m0    pench-b6h043    pench-b6h270    pench-b6h303    pench-b6hcx0    pench-b6hfx1    pench-b6hjt6    pench-b6hm64    pench-b6hmg2    pench-b6hnf2    pench-b6hnf7    pench-b6hph0    pench-b6huc9    penrw-b6hdc6    pench-q3v6c9    pencw-atg15    pencw-b6gwt5    pencw-b6gx34    pencw-b6gzd8    pencw-b6gzp7    pencw-b6h2f4    pencw-b6h2h0    pencw-b6h2n4    pencw-b6h3u7    pencw-b6h4n3    pencw-b6h4s6    pencw-b6h5k2    pencw-b6h6t6    pencw-b6h7f0    pencw-b6h7r1    pencw-b6h8a0    pencw-b6h8i1    pencw-b6h828    pencw-b6ha41    pencw-b6hat0    pencw-b6hb79    pencw-b6hcq8    pencw-b6hfx7    pencw-b6hgb0    pencw-b6hhg8    pencw-b6hjj1    pencw-b6hl02    pencw-b6hmd9    pencw-b6hmh5    pencw-b6hmh7    pencw-b6hpn2    pencw-b6hpz6    pencw-b6hqu4    pencw-b6hs49    pencw-b6hun6    pencw-b6hv09    pencw-cuti1    pencw-cuti2    pencw-dapb    pencw-b6had0    pencw-b6h497    pencw-b6gw76    pencw-b6hs05    pencw-b6h0h6    penna-a0a1v6yep8    penrw-b6huu8    penrw-kex1    penrw-cbpya    penrw-adrd
Gene_locus_frgt pench-b6gw01    pench-b6gwp9    pench-b6gzt9    pench-b6h2r5    pench-b6h3c6    pench-b6h3s3    pench-b6h6w7    pench-b6h7m0    pench-b6h043    pench-b6h270    pench-b6h303    pench-b6hcx0    pench-b6hfx1    pench-b6hjt6    pench-b6hm64    pench-b6hmg2    pench-b6hnf2    pench-b6hnf7    pench-b6hph0    pench-b6huc9    penrw-b6hdc6    pench-q3v6c9    pencw-atg15    pencw-b6gwt5    pencw-b6gx34    pencw-b6gzd8    pencw-b6gzp7    pencw-b6h2f4    pencw-b6h2h0    pencw-b6h2n4    pencw-b6h3u7    pencw-b6h4n3    pencw-b6h4s6    pencw-b6h5k2    pencw-b6h6t6    pencw-b6h7f0    pencw-b6h7r1    pencw-b6h8a0    pencw-b6h8i1    pencw-b6h828    pencw-b6ha41    pencw-b6hat0    pencw-b6hb79    pencw-b6hcq8    pencw-b6hfx7    pencw-b6hgb0    pencw-b6hhg8    pencw-b6hjj1    pencw-b6hl02    pencw-b6hmd9    pencw-b6hmh5    pencw-b6hmh7    pencw-b6hpn2    pencw-b6hpz6    pencw-b6hqu4    pencw-b6hs49    pencw-b6hun6    pencw-b6hv09    pencw-cuti1    pencw-cuti2    pencw-dapb    pencw-b6had0    pencw-b6h497    pencw-b6gw76    pencw-b6hs05    pencw-b6h0h6    penna-a0a1v6yep8    penrw-b6huu8    penrw-kex1    penrw-cbpya    penrw-adrd    pench-b6hsx4

Citations formats

van den Berg MA, Albang R, Albermann K, Badger JH, Daran JM, Driessen AJ, Garcia-Estrada C, Fedorova ND, Harris DM, Heijne WH, Joardar V, Kiel JA, Kovalchuk A, Martin JF, Nierman WC, Nijland JG, Pronk JT, Roubos JA, van der Klei IJ, van Peij NN, Veenhuis M, von Dohren H, Wagner C, Wortman J, Bovenberg RA (2008)
Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
Nat Biotechnol 26 :1161

van den Berg MA, Albang R, Albermann K, Badger JH, Daran JM, Driessen AJ, Garcia-Estrada C, Fedorova ND, Harris DM, Heijne WH, Joardar V, Kiel JA, Kovalchuk A, Martin JF, Nierman WC, Nijland JG, Pronk JT, Roubos JA, van der Klei IJ, van Peij NN, Veenhuis M, von Dohren H, Wagner C, Wortman J, Bovenberg RA (2008)
Nat Biotechnol 26 :1161