BACKGROUND The T allele of the hepatic
lipase HL C-514T polymorphism was previously found
to be associated with lower plasma HL
activity Here we examined the association between
this polymorphism and plasma HDL-cholesterol concentrations in
patients with coronary arteries stenosis METHODS We
studied 342 subjects undergoing coronary angiography in
two groups of non CAD n=146 and
CAD n=196 514C-->T polymorphism was determined using
polymerase chain reaction and restriction fragment length
polymorphism PCR-RFLP RESULTS After adjustment for age
smoking and body mass index HDL-cholesterol concentrations
were significantly higher in men with the
C/T&T/T genotype than those with the C/C
genotype(mean 38.6 and 34.7 respectively P=0.01 The
frequency of T allele in non CAD
was 0.136 and 0.226 in female and
male respectively and 0.170 and 0.223 for
female and male in CAD subjects There
was no difference in T allele frequency
in CAD and none CAD groups in
male and female P=0.466 and 0.722 respectively
CONCLUSION 514C-->T of LIPC gene have a
positive effect on HDL-C concentration especially in
male gender However no difference was determined
in frequency of T allele between CAD
and normal arteries subjects.
Ghatreh Samani K, Noori M, Nobar MR, Chaleshtory MH, Farrokhi E, Amin MD (2012) The -514C/T Polymorphism of Hepatic Lipase Gene among Iranian Patients with Coronary Heart Disease Iran J Public Health41: 59-65
Ghatreh Samani K, Noori M, Nobar MR, Chaleshtory MH, Farrokhi E, Amin MD (2012) Iran J Public Health41: 59-65
