| Title : Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin - Martin_2015_Bioorg.Med.Chem_23_7529 |
| Author(s) : Martin BP , Vasilieva E , Dupureur CM , Spilling CD |
| Ref : Bioorganic & Medicinal Chemistry , 23 :7529 , 2015 |
|
Abstract :
New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product. |
| PubMedSearch : Martin_2015_Bioorg.Med.Chem_23_7529 |
| PubMedID: 26585276 |
| Inhibitor | Cyclophostin |
Martin BP, Vasilieva E, Dupureur CM, Spilling CD (2015)
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin
Bioorganic & Medicinal Chemistry
23 :7529
Martin BP, Vasilieva E, Dupureur CM, Spilling CD (2015)
Bioorganic & Medicinal Chemistry
23 :7529