Paper Report for: Mizoi_2016_Bioorg.Med.Chem.Lett_26_921
Reference
Title: Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases Mizoi K, Takahashi M, Haba M, Hosokawa M Ref: Bioorganic & Medicinal Chemistry Lett, 26:921, 2016 : PubMed
We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results suggested that these ester compounds of atorvastatin have the potential to act as prodrugs in vivo.
        
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Mizoi K, Takahashi M, Haba M, Hosokawa M (2016) Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases Bioorganic & Medicinal Chemistry Lett26: 921-3
Mizoi K, Takahashi M, Haba M, Hosokawa M (2016) Bioorganic & Medicinal Chemistry Lett26: 921-3