| Title : Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases - Mizoi_2016_Bioorg.Med.Chem.Lett_26_921 |
| Author(s) : Mizoi K , Takahashi M , Haba M , Hosokawa M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :921 , 2016 |
|
Abstract :
We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results suggested that these ester compounds of atorvastatin have the potential to act as prodrugs in vivo. |
| PubMedSearch : Mizoi_2016_Bioorg.Med.Chem.Lett_26_921 |
| PubMedID: 26750256 |
Mizoi K, Takahashi M, Haba M, Hosokawa M (2016)
Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases
Bioorganic & Medicinal Chemistry Lett
26 :921
Mizoi K, Takahashi M, Haba M, Hosokawa M (2016)
Bioorganic & Medicinal Chemistry Lett
26 :921