Paper Report for: Takwa_2011_Chem.Commun.(Camb)_47_7392
Reference
Title: Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide Takwa M, Larsen MW, Hult K, Martinelle M Ref: Chem Commun (Camb), 47:7392, 2011 : PubMed
Based on molecular modelling, the enzyme Candida antarctica lipase B was redesigned as a catalyst for the ring opening polymerization of D,D-lactide. Two mutants with 90-fold increased activity as compared to the wild-type enzyme were created. In a preparative synthesis of poly(D,D-lactide) the mutants greatly improved the rate and the degree of polymerization.
Takwa M, Larsen MW, Hult K, Martinelle M (2011) Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide Chem Commun (Camb)47: 7392-4
Takwa M, Larsen MW, Hult K, Martinelle M (2011) Chem Commun (Camb)47: 7392-4