Reactivator

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Reactivator Report for: MB327

General
Type Bispyridinium, non-oxime
Chemical_Nomenclature 4-tert-butyl-1-[3-(4-tert-butylpyridin-1-ium-1-yl)propyl]pyridin-1-ium
Canonical SMILES CC(C)(C)C1=CC=[N+](C=C1)CCC[N+]2=CC=C(C=C2)C(C)(C)C
InChI InChI=1S/C21H32N2/c1-20(2,3)18-8-14-22(15-9-18)12-7-13-23-16-10-19(11-17-23)21(4,5)6/h8-11,14-17H,7,12-13H2,1-6H3/q+2
InChIKey OBKUQIPOSJEQDO-UHFFFAOYSA-N
Other name(s) C571852 ; CHEMBL1642972 ; CHEMBL1739618 ; BDBM50334316 ; 1,1'-(Trimethylene)bis(4-tert-butylpyridinium) ; 1,3-bis(4-tert.butylpyridinium)-prop-1,3-diyl dibromide
________________________________________________________________________________________________
MW|312.49
Formula|C21H3N2O
CAS_number|
PubChem|12282872
UniChem|OBKUQIPOSJEQDO-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: MB327

3 more
    Title: Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point
    Price ME, Whitmore CL, Tattersall JEH, Green AC, Rice H
    Ref: Toxicol Lett, 293:167, 2018 : PubMed

            

    Title: Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro
    Seeger T, Eichhorn M, Lindner M, Niessen KV, Tattersall JE, Timperley CM, Bird M, Green AC, Thiermann H, Worek F
    Ref: Toxicology, 294:80, 2012 : PubMed

            

    Title: Interaction of bispyridinium compounds with the orthosteric binding site of human alpha7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs)
    Niessen KV, Tattersall JE, Timperley CM, Bird M, Green C, Seeger T, Thiermann H, Worek F
    Ref: Toxicol Lett, 206:100, 2011 : PubMed

            


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer