11TW
Name : Crystal structure of alpha\/beta-hydrolase macrolide esterase EstX from Escherichia coli (S102A mutant) in complex with linearized tylvalosin
Revelation date : 08-Apr-2026
Family : Aclacinomycin-methylesterase_RdmC
Gene_locus : ecoli-estX
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Kelly, E.T.R.,Blanchet, J.,Berghuis, A.M. 2026-03-12
Ligand : substrate Tylvalosin, Tylvalosin-linearized Ligand in structure: Ligplot
References (1)
| Title : Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases - Kelly_2026_bioRxiv__ |
| Author(s) : Kelly ETR , Myziuk I , Hemmings MZ , Mulla Z , Blanchet J , Ruzzini A , Berghuis AM |
| Ref : bioRxiv , :202603.24.713787 , 2026 |
| Abstract : |
| PubMedSearch : Kelly_2026_bioRxiv__ |
| PubMedID: |
| Gene_locus related to this paper: 9sphi-EstT , bacce-EstT , 9sphi-b5apj0 , ecoli-estX |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 11TW Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 11TW Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 11TW Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 11TW 3D, interactive encyclopedia of proteins - PROTEOPEDIA server