9sphi-b5apj0

Sphingobacterium sp.; Sphingobacterium faecium Putative streptothricin resistance protein; macrolide esterase EstT EsTSf

Comment

Other strains: Sphingobacterium sp. PM2-P1-29\; Sphingobacterium faecium strain WB1 plasmid pWB1\; Moraxella pluranimalium\; Riemerella anatipestifer (Moraxella anatipestifer)\; Glaesserella parasuis (Haemophilus parasuis)\; uncultured bacterium\; Christiangramia sediminicola

Relationship

Family : Aclacinomycin-methylesterase_RdmC

Block : X

Position in NCBI Life Tree : Sphingobacterium sp. PM2-P1-29

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > FCB group N E > Bacteroidetes\/Chlorobi group N E > Bacteroidetes N E > Sphingobacteriia N E > Sphingobacteriales N E > Sphingobacteriaceae N E > Sphingobacterium N E > Sphingobacterium sp. PM2-P1-29 N E

Molecular evidence

No mutation

No kinetic

No disease

No inhibitor

Sequence

Peptide

MKKKLLWILI LGLIIISCKQ RKTEMKEKII KTNGIELCTE SFGNKKNPAI LLVAGATVSM LYWDTEFCQQ LSEKGFFVIR YDNRDVGKST NYEPGSTPYD IVDLTNDAIS ILDGYKIDKA HFVGISLGGL ISQIASIKFA DRVNSLTLMS SGPWGDSDPT IPEMDTSILD FHSKAGTVNW TNEDSVVNYL IQGAELMSGK KQFDKQRSEK LIRAEFNRAN NYISMFNHAA SQGGGGEEYW NRLNEIKQPT LIIHGTDDKI WHYKNAGFLL EKIKGSNLIT LEGTGHELHV DDWKSIIDGI EKHIND

References (4)

Title : Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases - Kelly_2026_bioRxiv__
Author(s) : Kelly ETR , Myziuk I , Hemmings MZ , Mulla Z , Blanchet J , Ruzzini A , Berghuis AM
Ref : bioRxiv , :202603.24.713787 , 2026
Abstract :
PubMedSearch : Kelly_2026_bioRxiv__
PubMedID:
Gene_locus related to this paper: 9sphi-EstT , bacce-EstT , 9sphi-b5apj0 , ecoli-estX

Title : Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases - Kelly_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2611077123
Author(s) : Kelly ETR , Myziuk I , Hemmings MZ , Mulla Z , Blanchet J , Ruzzini A , Berghuis AM
Ref : Proc Natl Acad Sci U S A , 123 :e2611077123 , 2026
Abstract :
PubMedSearch : Kelly_2026_Proc.Natl.Acad.Sci.U.S.A_123_e2611077123
PubMedID: 42455676
Gene_locus related to this paper: 9sphi-EstT , bacce-EstT , 9sphi-b5apj0 , ecoli-estX

Title : A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase - Dhindwal_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219827120
Author(s) : Dhindwal P , Thompson C , Kos D , Planedin K , Jain R , Jelinski M , Ruzzini A
Ref : Proc Natl Acad Sci U S A , 120 :e2219827120 , 2023
Abstract :
PubMedSearch : Dhindwal_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219827120
PubMedID: 36791107
Gene_locus related to this paper: 9sphi-b5apj0

Title : Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline - Ghosh_2009_J.Appl.Microbiol_106_1336
Author(s) : Ghosh S , Sadowsky MJ , Roberts MC , Gralnick JA , LaPara TM
Ref : J Appl Microbiol , 106 :1336 , 2009
Abstract :
PubMedSearch : Ghosh_2009_J.Appl.Microbiol_106_1336
PubMedID: 19187139
Gene_locus related to this paper: 9sphi-b5apj0