Aclacinomycin-methylesterase_RdmC

Relationship

Family: Aclacinomycin-methylesterase_RdmC

Block: X

Parent Family: Abhydrolase_6

Comment

PIRSF037216 Aclacinomycin methylesterase (RdmC) is one of the tailoring enzymes that modify the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species. alcbs-q0vlq1 EH83 is a polyacetic acid hydrolase

Database

Interpro : IPR000073 Alpha\/beta hydrolase fold-1

PIRSF : PIRSF037216

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : 3.1.1.95

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (2)

Genes Proteins in Aclacinomycin-methylesterase_RdmC family (213)

Fragments of genes in Aclacinomycin-methylesterase_RdmC family (2)

Structures in Aclacinomycin-methylesterase_RdmC family (2)

Substrates in Aclacinomycin-methylesterase_RdmC family (3)

Inhibitors in Aclacinomycin-methylesterase_RdmC family (2)

References (3)

Title : Biochemical and Structural Insights into Enzymatic Depolymerization of Polylactic Acid and Other Polyesters by Microbial Carboxylesterases - Hajighasemi_2016_Biomacromolecules_17_2027
Author(s) : Hajighasemi M , Nocek BP , Tchigvintsev A , Brown G , Flick R , Xu X , Cui H , Hai T , Joachimiak A , Golyshin PN , Savchenko A , Edwards EA , Yakunin AF
Ref : Biomacromolecules , 17 :2027 , 2016
PubMedID: 27087107
Gene_locus related to this paper: marav-a1u5n0 , rhopa-q6n9m9 , alcbs-q0vlq1

Title : Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism - Jansson_2003_J.Biol.Chem_278_39006
Author(s) : Jansson A , Niemi J , Mantsala P , Schneider G
Ref : Journal of Biological Chemistry , 278 :39006 , 2003
PubMedID: 12878604
Gene_locus related to this paper: ecoli-rdmC , strpu-rdmC

Title : Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens - Wang_2000_Biochim.Biophys.Acta_1480_191
Author(s) : Wang Y , Niemi J , Airas K , Ylihonko K , Hakala J , Mantsala P
Ref : Biochimica & Biophysica Acta , 1480 :191 , 2000
PubMedID: 11004563