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Aclacinomycin-methylesterase_RdmC

Relationship

Family: Aclacinomycin-methylesterase_RdmC

Block: X

Parent Family: Abhydrolase_6

Comment

Macrolide esterases (antimicrobial resistance gene) PIRSF037216 Aclacinomycin methylesterase (RdmC) is one of the tailoring enzymes that modify the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species. alcbs-q0vlq1 EH83 is a polyacetic acid hydrolase. Also contains the macrolide esterase EstX. The founding member of this family, UXD71803 9sphi-b5apj0, was shown to hydrolyze macrolides with 16-atom lactone ring structures, such as tylosin, tilmicosin, and tildipirosin, but not macrolides such as erythromycin, tulathromycin, gamithromycin with 14- or 15-atom rings. EstT belongs to the larger family of alpha/beta-fold hydrolases. (NCBIfam NF041759 mac_hydro_EstT)

Database

Interpro : IPR000073 Alpha\/beta hydrolase fold-1

PIRSF : PIRSF037216

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : 3.1.1.95

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
11TS Crystal structure of apo alpha\/beta-hydrolase macrolide esterase EstT from Sphingobacterium faecium (S126A mutant) 9sphi-b5apj0
11TT Crystal structure of apo alpha\/beta-hydrolase macrolide esterase EstT from Sphingobacterium thalpophilum (S102A mutant) 9sphi-EstT
11TU Crystal structure of alpha\/beta-hydrolase macrolide esterase EstT from Bacillus cereus (S102A mutant) in complex with linearized tylvalosin bacce-EstT
11TV Crystal structure of alpha\/beta-hydrolase macrolide esterase EstX from Escherichia coli (S102A mutant) in complex with linearized tylosin ecoli-estX
11TW Crystal structure of alpha\/beta-hydrolase macrolide esterase EstX from Escherichia coli (S102A mutant) in complex with linearized tylvalosin ecoli-estX
1Q0R Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin T (DcmaT) strpu-rdmC
1Q0Z Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin A (DcmA) strpu-rdmC
8PZG Metagenomic lipase ORF17 9bact-ORF17.8PZG

Gene_locus Name Species
9acto-b5g999 Streptomyces sp. SPB74 Carboxyl esterase Streptomyces sp. SPB74
9acto-b5hp47 Streptomyces sviceus ATCC 29083 Putative uncharacterized protein Streptomyces sviceus ATCC 29083
9acto-d1xnm4 Streptomyces sp. ACTE Alpha\/beta hydrolase fold protein Streptomyces sp. ACTE
9acto-d3ctl7 Frankia sp. EUN1f Alpha\/beta hydrolase fold protein Frankia sp. EUN1f
9acto-d3cww2 Frankia sp. EUN1f Alpha\/beta hydrolase fold protein Frankia sp. EUN1f
9acto-d3m5d4 Frankia symbiont of Datisca glomerata Alpha\/beta hydrolase fold protein Frankia symbiont of Datisca glomerata
9alte-a6f626 Marinobacter algicola DG893 Predicted Hydrolase or acyltransferase (Alpha\/beta hydrolase superfamily) protein Marinobacter algicola DG893
9bacl-mlePBB.1 Paenibacillus sp. SYP-B3998 macrolide esterase mlePBB-1 Paenibacillus sp. SYP-B3998
9bact-EST5 uncultured bacterium EST5 uncultured bacterium
9bact-ORF17.8PZG uncultured bacterium Metagenomic lipase ORF17 uncultured bacteria
9bact-a9ukk2 uncultured bacterium Lipase\/esterase uncultured bacterium
9bact-b0l3i3 uncultured bacterium Lipase\/esterase uncultured bacterium
9bact-b8y566 uncultured bacterium Lipolytic enzyme uncultured bacterium
9bact-c3rww3 uncultured bacterium Putative lipase\/esterase uncultured bacterium
9bact-estC55.197 uncultured bacterium. Lipolytic protein uncultured bacterium
9bact-g3c5s9 uncultured bacterium. Lipase\/esterase uncultured bacterium
9bact-g3c5t0 uncultured bacterium. Lipase\/esterase uncultured bacterium
9burk-a6gu41 Limnobacter sp. MED105 Alpha\/beta hydrolase superfamily protein interrupted gene pseudogene Limnobacter sp. MED105
9burk-c9y9d4 Curvibacter putative symbiont of Hydra magnipapillata Putative uncharacterized protein Curvibacter putative symbiont of Hydra magnipapillata
9cyan-OCA.1 Oscillatoriales cyanobacterium C42_A2020_001 Macrolide esterase OCA-1 Oscillatoriales cyanobacterium C42_A2020_001
9cyan-OCB.1 Oculatellaceae cyanobacterium Prado106 Macrolide esterase OCB-1 Oculatellaceae cyanobacterium Prado106
9cyan-a0a927enu2 Phormidium tenue FACHB-886 Macrolide esterase NOD-1 Phormidium tenue FACHB-886
9delt-q5md37 Cystobacter fuscus hypothetical protein Cystobacter fuscus
9entr-b6xhq2 Providencia alcalifaciens DSM 30120 Putative uncharacterized protein Providencia alcalifaciens DSM 30120
9entr-d1nyt4 Providencia rustigianii DSM 4541 Carboxyl esterase Providencia rustigianii DSM 4541
9gamm-a0abn0jus0 Acinetobacter soli NIPH 2899 AB hydrolase-1 domain-containing protein EstZ Acinetobacter soli NIPH 2899
9gamm-a0aby2xlv8 Alloalcanivorax gelatiniphagus. Alpha\/beta hydrolase AGE_12 Alloalcanivorax gelatiniphagus
9gamm-a0xyk4 Alteromonadales bacterium TW-7 probable hydrolase Alteromonadales bacterium TW-7
9gamm-a0ycy2 marine gamma proteobacterium HTCC2143 probable hydrolase (fragment) marine gamma proteobacterium HTCC2143
9gamm-a0z5e8 marine gamma proteobacterium HTCC2080 probable hydrolase marine gamma proteobacterium HTCC2080
9gamm-a4ada0 Congregibacter litoralis KT71 gamma proteobacterium NOR5-3 Carboxyl esterase, a\/b hydrolase Congregibacter litoralis KT71
9gamm-b5jtx2 gamma proteobacterium HTCC5015 Putative uncharacterized protein gamma proteobacterium HTCC5015
9gamm-b5jwt0 gamma proteobacterium HTCC5015 Hydrolase, alpha\/beta fold family gamma proteobacterium HTCC5015
9gamm-b5jx25 gamma proteobacterium HTCC5015 Hydrolase, alpha\/beta fold family protein gamma proteobacterium HTCC5015
9gamm-b8khd4 gamma proteobacterium NOR5-3 Putative uncharacterized protein gamma proteobacterium NOR5-3
9gamm-b8ksy0 gamma proteobacterium NOR51-B Putative uncharacterized protein gamma proteobacterium NOR51-B
9gamm-c8pvt7 Enhydrobacter aerosaccus SK60 Hydrolase, alpha\/beta fold family Enhydrobacter aerosaccus SK60
9gamm-c8pza4 Enhydrobacter aerosaccus SK60 Hydrolase, alpha\/beta fold family Enhydrobacter aerosaccus SK60
9gamm-q1ype7 marine gamma proteobacterium HTCC2207 probable hydrolase marine gamma proteobacterium HTCC2207
9gamm-q1yty4 marine gamma proteobacterium HTCC2207 probable hydrolase marine gamma proteobacterium HTCC2207
9mico-a3tjp7 Janibacter sp. HTCC2649 Probable hydrolase Janibacter sp. HTCC2649
9mico-a3trw6 Janibacter sp. HTCC2649 Carboxylesterase Janibacter sp. HTCC2649
9noca-c0stw9 Rhodococcus sp. HI-31 Putative hydrolase Rhodococcus sp. HI-31
9rhiz-c8sk39 Mesorhizobium opportunistum WSM2075 Alpha\/beta hydrolase fold protein Mesorhizobium opportunistum WSM2075
9rhob-a3tt13 Oceanicola batsensis HTCC2597 Probable hydrolase Oceanicola batsensis HTCC2597
9rhob-a3vhi4 Maritimibacter alkaliphilus HTCC2654 Putative hydrolase Maritimibacter alkaliphilus HTCC2654
9rhob-b5kex1 Octadecabacter antarcticus 238 Putative uncharacterized protein Octadecabacter antarcticus 238
9sphi-EstT Sphingobacterium thalpophilum alpha\/beta-hydrolase macrolide esterase EstT Sphingobacterium thalpophilum
9sphi-b5apj0 Sphingobacterium sp.\; Sphingobacterium faecium Putative streptothricin resistance protein\; macrolide esterase EstT Sphingobacterium sp. PM2-P1-29
9sphn-a3wh04 Erythrobacter sp. NAP1 Probable hydrolase Erythrobacter sp. NAP1
9sphn-a5p8z5 Erythrobacter sp. SD-21 Probable hydrolase Erythrobacter sp. SD-21
9sphn-q2n7c0 Erythrobacter litoralis HTCC2594 probable hydrolase Erythrobacter litoralis HTCC2594
9tryp-c6k3q7 Crithidia sp. ATCC 30255 Putative hydrolase-like protein Crithidia sp. ATCC 30255
9tryp-c6k3q8 Crithidia sp. ATCC 30255 Putative hydrolase-like protein Crithidia sp. ATCC 30255
9tryp-c6k3q9 Crithidia sp. ATCC 30255 Putative hydrolase-like protein Crithidia sp. ATCC 30255
accpu-c7rr72 Accumulibacter phosphatis (strain UW-1) Alpha\/beta hydrolase fold protein Accumulibacter phosphatis
accpu-c7rtu4 Accumulibacter phosphatis (strain UW-1) Alpha\/beta hydrolase fold protein Accumulibacter phosphatis
acic5-c1f7a9 Acidobacterium capsulatum (strain ATCC 51196 \/ DSM 11244 \/ JCM 7670) Hydrolase, alpha\/beta fold family Acidobacterium capsulatum
acica-d0s0a7 Acinetobacter calcoaceticus, Acinetobacter sp. , Acinetobacter baumannii, Acinetobacter junii Alpha\/beta hydrolase fold protein EstB Acinetobacter calcoaceticus
acica-estB Acinetobacter calcoaceticus DNA for EstB Acinetobacter calcoaceticus
acijo-d0sar0 Acinetobacter johnsonii SH046 Alpha\/beta hydrolase fold protein EstB Acinetobacter johnsonii SH046
acilw-d0sul3 Acinetobacter lwoffii SH145 Alpha\/beta hydrolase superfamily protein Acinetobacter lwoffii SH145
acira-c6rme7 Acinetobacter radioresistens (strains SK82\; SH164) Hydrolase, alpha\/beta fold family Acinetobacter radioresistens SK82
agrrk-b9j7k2 Agrobacterium radiobacter (strain K84 \/ ATCC BAA-868) Hydrolase protein Agrobacterium radiobacter
alcbs-q0vlq1 Alcanivorax borkumensis (strain SK2 \/ ATCC 700651 \/ DSM 11573) Alcanivorax sp. DG881, ABO_2449 EH83 polyacetic acid hydrolase ABO_2249 Alcanivorax borkumensis
alkmq-a6tql7 Alkaliphilus metalliredigens (strain QYMF) Alpha\/beta hydrolase fold Alkaliphilus metalliredigens
azovd-c1dqu3 Azotobacter vinelandii (strain DJ \/ ATCC BAA-1303\; AvOP) Alpha\/beta hydrolase fold protein Azotobacter vinelandii
bacah-a0rev7 Bacillus thuringiensis (strain Al Hakam) Bacillus cereus (strains NVH0597-99\; Rock3-42\; 03BB108\; BGSC 6E1\; 03BB102) carboxylesterase (EC 3.1.1.1) Bacillus thuringiensis
bacan-BA2738 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase, alpha\/beta fold family Bacillus anthracis
bacce-BC2743 Bacillus cereus, Bacillus thuringiensis carboxylesterase (EC 3.1.1.1) Bacillus cereus
bacce-EstT Bacillus cereus alpha\/beta-hydrolase macrolide esterase EstT Bacillus cereus
bacce-c2xlh1 Bacillus cereus, Bacillus thuringiensis, alpha\/beta-hydrolase macrolide esterase EstT Bacillus cereus F65185
bacce-c2zq05 Bacillus cereus (AH1273\; AH1272\; AH603\; AH621\; BDRD-ST196) Bacillus mycoides DSM 2048 Bacillus weihenstephanensis (strain KBAB4) Putative uncharacterized protein Bacillus cereus
bacce-mleBCB.1 Bacillus cereus\; Bacillus thuringiensis macrolide esterase mle_BCB-1 Bacillus cereus
bacce-q736x9 Bacillus cereus\; Bacillus tropicus, hydrolase, alpha\/beta fold family mle_BCA-1 Bacillus cereus
baccz-q63ak5 Bacillus cereus (strain ZK) carboxylesterase (EC 3.1.1.1) Bacillus cereus
bachk-q6hhz3 Bacillus thuringiensis, Bacillus cereus, Bacillus thuringiensis, carboxylesterase (EC 3.1.1.1) Bacillus thuringiensis
bacmy-c3aly3 Bacillus mycoides (strains Rock1-4 Rock3-17) Bacillus pseudomycoides DSM 12442 Putative uncharacterized protein Bacillus mycoides
bacti-q3f0c3 Bacillus thuringiensis serovar israelensis ATCC 35646, carboxylesterase (EC 3.1.1.1) Bacillus thuringiensis serovar israelensis ATCC 35646
beii9-b2iaz3 Beijerinckia indica subsp. indica (strain ATCC 9039 \/ DSM 1715 \/ NCI 8712) Alpha\/beta hydrolase fold Beijerinckia indica subsp. indica
beuc1-c5bvm8 Beutenbergia cavernae (strain ATCC BAA-8 \/ DSM 12333 \/ NBRC 16432) Alpha\/beta hydrolase fold protein Beutenbergia cavernae
braja-BLL2884 Bradyrhizobium japonicum bll2884 protein Bradyrhizobium japonicum
brasb-a5efp4 Bradyrhizobium sp. (strain BTAi1 \/ ATCC BAA-1182\; ORS278) Putative uncharacterized protein Bradyrhizobium sp.
braso-a4yr10 Bradyrhizobium sp. (strain ORS278) Putative uncharacterized protein Bradyrhizobium sp.
brebn-c0z8w7 Brevibacillus brevis (strain 47 \/ JCM 6285 \/ NBRC 100599) macrolide esterase mle_BRB-1 Brevibacillus brevis
burs3-q39ns4 Burkholderia sp. (strain 383) Burkholderia cepacia strain ATCC 1776 alpha\/beta hydrolase (EC 1.11.1.10) Burkholderia sp.
catad-c7qat2 Catenulispora acidiphila (strain DSM 44928 \/ NRRL B-24433 \/ NBR 102108 \/ JCM 14897) Alpha\/beta hydrolase fold protein Catenulispora acidiphila
catad-c7qav4 Catenulispora acidiphila (strain DSM 44928 \/ NRRL B-24433 \/ NBR 102108 \/ JCM 14897) Alpha\/beta hydrolase fold protein Catenulispora acidiphila
causk-b0t2p6 Caulobacter sp. (strain K31) Alpha\/beta hydrolase fold Caulobacter sp.
causk-b0t721 Caulobacter sp. (strain K31) Alpha\/beta hydrolase fold Caulobacter sp.
cloac-CAP0097 Clostridium acetobutylicum carboxyl esterase, a\/b hydrolase Clostridium acetobutylicum
clob8-a6lyd7 Clostridium beijerinckii (strain ATCC 51743 \/ NCIMB 8052) (Clostridium acetobutylicum) Alpha\/beta hydrolase fold Clostridium beijerinckii
conwi-d3f461 Conexibacter woesei (strain DSM 14684 \/ JCM 11494 \/ NBRC 100937 \/ ID131577) Alpha\/beta hydrolase fold protein Conexibacter woesei
conwi-d3f719 Conexibacter woesei (strain DSM 14684 \/ JCM 11494 \/ NBRC 100937 \/ ID131577) Alpha\/beta hydrolase fold protein Conexibacter woesei
conwi-d3f8h2 Conexibacter woesei (strain DSM 14684 \/ JCM 11494 \/ NBRC 100937 \/ ID131577) Alpha\/beta hydrolase fold protein Conexibacter woesei
conwi-d3f9s1 Conexibacter woesei (strain DSM 14684 \/ JCM 11494 \/ NBRC 100937 \/ ID131577) Alpha\/beta hydrolase fold protein Conexibacter woesei
conwi-d3fd66 Conexibacter woesei (strain DSM 14684 \/ JCM 11494 \/ NBRC 100937 \/ ID131577) Alpha\/beta hydrolase fold protein Conexibacter woesei
cytfi-mleCBF.1 Cytobacillus firmus macrolide esterase mleCBF-1 Cytobacillus firmus
decar-q47c05 Dechloromonas aromatica (strain RCB) alpha\/beta hydrolase fold Dechloromonas aromatica
desaa-b8fl18 Desulfatibacillum alkenivorans (strain AK-01) Alpha\/beta hydrolase fold protein Desulfatibacillum alkenivorans
desaa-b8flr5 Desulfatibacillum alkenivorans (strain AK-01) Alpha\/beta hydrolase fold protein Desulfatibacillum alkenivorans
ecoli-estX Escherichia coli sat streptothricin acetyl-transferase (on plasmid) (and strains SMS-3-5\/SECEC\; H489 ) Escherichia coli
ecoli-rdmC Escherichia coli macrolide 2'-phosphotransferase II, homlogue of strpu-rdmC possible C-C hydrolase Escherichia coli
erwct-q6d508 Erwinia carotovora (subsp. atroseptica) (Pectobacterium atrosepticum) Pectobacterium wasabiae (strain WPP163) probable hydrolase Erwinia carotovora
fraaa-q0rci1 Frankia alni (strain ACN14a) putative prolyl aminopeptidase Frankia alni
frasc-q2j632 Frankia sp. (strain CcI3) alpha\/beta hydrolase fold Frankia sp. CcI3
frasc-q2jb56 Frankia sp. (strain CcI3) alpha\/beta hydrolase fold Frankia sp. CcI3
frasn-a8l161 Frankia sp. (strain EAN1pec) Alpha\/beta hydrolase fold Frankia sp.
geoog-d2sh40 Geodermatophilus obscurus (strain ATCC 25078 \/ DSM 43160 \/ JCM 3152 \/ G-20) Alpha\/beta hydrolase fold protein Geodermatophilus obscurus
gluda-b5zhs5 Gluconacetobacter diazotrophicus (strain ATCC 49037 \/ DSM 5601 \/ PAl5) Alpha\/beta hydrolase fold Gluconacetobacter diazotrophicus
grabc-q0bsz9 Granulobacter bethesdensis (strain ATCC BAA-1260 \/ CGDNIH1) carboxylesterase (EC 3.1.1.1) Granulobacter bethesdensis
hahch-q2s803 Hahella chejuensis (strain KCTC 2396) AlphaBeta_hydrolase superfamily Hahella chejuensis
hahch-q2skv5 Hahella chejuensis (strain KCTC 2396)AlphaBeta_hydrolase superfamily) Hahella chejuensis
halo1-d0lx47 Haliangium ochraceum (strain DSM 14365 \/ JCM 11303 \/ SMP-2) Alpha\/beta hydrolase fold protein Haliangium ochraceum
herar-a4g4w8 Herminiimonas arsenicoxydans Putative alpha\/beta hydrolase Herminiimonas arsenicoxydans
hypna-q0bwt8 Hyphomonas neptunium (strain ATCC 15444) hydrolase, alpha\/beta fold family Hyphomonas neptunium
janma-a6sz66 Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) Carboxyl esterase, a\/b hydrolase Janthinobacterium sp. Marseille
janma-a6szj6 Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) Uncharacterized conserved protein Janthinobacterium sp. Marseille
klepn-c4pg07 Klebsiella pneumoniae Streptothricin acetyl-transferase Klebsiella pneumoniae
kocrd-b2ghy5 Kocuria rhizophila (strain ATCC 9341 \/ DSM 348 \/ NBRC 103217 \/ DC2201) Putative hydrolase Kocuria rhizophila
krifd-d2q3t3 Kribbella flavida (strain DSM 17836 \/ JCM 10339 \/ NBRC 14399) Alpha\/beta hydrolase fold protein Kribbella flavida
krifd-d2q445 Kribbella flavida (strain DSM 17836 \/ JCM 10339 \/ NBRC 14399) Alpha\/beta hydrolase fold protein Kribbella flavida
leibr-a4h956 Leishmania braziliensis\; Leishmania guyanensis Hydrolase, alpha\/beta fold family-like protein Leishmania braziliensis
leibr-a4h959 Leishmania braziliensis Hydrolase-like protein Leishmania braziliensis
leibr-a4h960 Leishmania braziliensis Hydrolase-like protein Leishmania braziliensis
leibr-a4hgl0 Leishmania braziliensis Putative hydrolase, alpha\/beta fold family Leishmania braziliensis
leiin-a4hxh8 Leishmania infantum Hydrolase, alpha\/beta fold family-like protein Leishmania infantum
leiin-a4hxi1 Leishmania infantum Hydrolase-like protein Leishmania infantum
leima-q4q8a8 Leishmania major Leishmania infantum hydrolase, alpha\/beta fold family, putative Leishmania major
leima-q4qe85 Leishmania major Leishmania infantum Leishmania braziliensis hydrolase-like protein (esterase-like protein) Leishmania major
leima-q4qe86 Leishmania major Leishmania infantum hydrolase-like protein (esterase-like protein) Leishmania major
leima-q4qe90 Leishmania major hydrolase, alpha\/beta fold family-like protein Leishmania major
meslo-mll3776 Mesorhizobium loti (Rhizobium loti) mll3776 streptothricin-acteyl-transferase Mesorhizobium loti
messb-q11g88 Mesorhizobium sp. (strain BNC1) alpha\/beta hydrolase fold Mesorhizobium sp.
metep-a9w0q4 Methylobacterium extorquens (strain PA1) Alpha\/beta hydrolase fold Methylobacterium extorquens
metrj-b1m0b7 Methylobacterium radiotolerans (strain ATCC 27329 \/ DSM 1819 \/ JC 2831) Alpha\/beta hydrolase fold Methylobacterium radiotolerans
myca9-b1mh71 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Probable lipase\/esterase LipG Mycobacterium abscessus
myca9-b1mh73 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Probable lipase\/esterase LipG Mycobacterium abscessus
mycgi-a4t1n2 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Alpha\/beta hydrolase fold protein Mycobacterium gilvum
mycle-lipG Mycobacterium leprae (strains TN\; Br4923) ML1899 lipG Mycobacterium leprae
mycpa-q73sf6 Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) lipg Mycobacterium avium
mycs2-a0qs51 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) hydrolase, alpha\/beta fold family protein BioH2 Mycobacterium smegmatis
mycsk-a1ubh7 Mycobacterium sp. (strain KMS and JLS and MCS) alpha\/beta hydrolase fold Mycobacterium sp.
myctu-lipG Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium paratuberculosis, lipG RV0646C MT0674 BioH2 Mycobacterium tuberculosis
mycua-a0pm12 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) lipase\/esterase lipg1 Mycobacterium ulcerans
mycua-a0pm14 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) lipase\/esterase lipg2 Mycobacterium ulcerans
mycvp-a1t1b4 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) alpha\/beta hydrolase fold Mycobacterium vanbaalenii
mycvp-a1t4h5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) alpha\/beta hydrolase fold Mycobacterium vanbaalenii
myxxd-q1d1c9 Myxococcus xanthus (strain DK 1622) esterase Myxococcus xanthus
myxxd-q1d2h8 Myxococcus xanthus (strain DK 1622) hydrolase, alpha\/beta fold family Myxococcus xanthus
nakmy-c8xfv3 Nakamurella multipartita (strain ATCC 700099 \/ DSM 44233 \/ JCM 9543 \/ Y-104) (Microsphaera multipartita) Alpha\/beta hydrolase fold protein Nakamurella multipartita
nech7-c7zdx8 Nectria haematococca (strain 77-13-4 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Putative uncharacterized protein Nectria haematococca
nocsj-a1sfj7 Nocardioides sp. (strain BAA-499 \/ JS614) alpha\/beta hydrolase fold Nocardioides sp.
novad-q2g848 Novosphingobium aromaticivorans (strain DSM 12444) alpha\/beta hydrolase Novosphingobium aromaticivorans
paesp-mlePBA.1 Paenibacillus sp. macrolide esterase mlePBA-1 Paenibacillus sp.
parl1-a7htr0 Parvibaculum lavamentivorans (strain DS-1 \/ DSM 13023 \/ NCIMB 13966) Alpha\/beta hydrolase fold Parvibaculum lavamentivorans
parl1-a7htr1 Parvibaculum lavamentivorans (strain DS-1 \/ DSM 13023 \/ NCIMB 13966) Alpha\/beta hydrolase fold Parvibaculum lavamentivorans
parl1-a7htr3 Parvibaculum lavamentivorans (strain DS-1 \/ DSM 13023 \/ NCIMB 13966) Alpha\/beta hydrolase fold Parvibaculum lavamentivorans
polna-a1vs35 Polaromonas naphthalenivorans (strain CJ2) alpha\/beta hydrolase fold Polaromonas naphthalenivorans
polsj-q126d1 Polaromonas sp. (strain JS666 \/ ATCC BAA-500) alpha\/beta hydrolase fold Polaromonas sp.
prore-d4btt4 Providencia rettgeri DSM 1131 Carboxyl esterase Providencia rettgeri DSM 1131
psea6-q15qh7 Pseudoalteromonas atlantica (strain T6c \/ BAA-1087) alpha\/beta hydrolase fold Pseudoalteromonas atlantica
pseae-PA3586 Pseudomonas aeruginosa (and strains UCBPP-PA14\; C3719\; LESB58\; 2192\; PA7) probable hydrolase Pseudomonas aeruginosa
pseae-Q9APW4 Pseudomonas aeruginosa hydrolase Pseudomonas aeruginosa
psee4-q1ie27 Pseudomonas entomophila (strain L48) putative hydrolase, alpha\/beta fold family Pseudomonas entomophila
psef5-q4k713 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) hydrolase, alpha\/beta fold family Pseudomonas fluorescens
psefs-c3k8y7 Pseudomonas fluorescens (strain SBW25) Putative exported hydrolase Pseudomonas fluorescens
psemy-a4xsy2 Pseudomonas mendocina (strain ymp) Alpha\/beta hydrolase fold protein Pseudomonas mendocina
psepf-q3k7h4 Pseudomonas fluorescens (strain PfO-1) alpha\/beta hydrolase fold precursor Pseudomonas fluorescens
psepu-PP1064 Pseudomonas putida (strains KT2440\; F1 \/ ATCC 700007\; GB-1) hydrolase, alpha\/beta fold family Pseudomonas putida
psepu-PP2804 Pseudomonas putida (strain KT2440) hydrolase, alpha\/beta fold family Pseudomonas putida
psepw-b1j4g1 Pseudomonas putida (strain W619) Alpha\/beta hydrolase fold Pseudomonas putida
psesy-PSPTO4178 Pseudomonas syringae (pv. tomato) hydrolase, alpha\/beta fold family Pseudomonas syringae
pseu2-q4zph7 Pseudomonas syringae pv. syringae (strain B728a) alpha\/beta hydrolase fold precursor Pseudomonas syringae pv. syringae
psyck-q1qbh3 Psychrobacter cryohalolentis, Psychrobacter arcticum, alpha\/beta hydrolase fold Psychrobacter cryohalolentis
psywf-a5wew0 Psychrobacter sp. (strain PRwf-1) Alpha\/beta hydrolase fold protein Psychrobacter sp.
psywf-a5wew1 Psychrobacter sp. (strain PRwf-1) Alpha\/beta hydrolase fold protein Psychrobacter sp.
ralp1-c6bnp5 Ralstonia pickettii (strain 12D) Alpha\/beta hydrolase fold protein Ralstonia pickettii
rhiec-q2k238 Rhizobium etli (strain CFN 42 \/ ATCC 51251\; CIAT 652) putative hydrolase protein Rhizobium etli
rhil3-q1m347 Rhizobium leguminosarum bv. viciae (strain 3841) putative streptothricin-acetyl-transferase Rhizobium leguminosarum bv. viciae
rhil3-q1mel6 Rhizobium leguminosarum bv. viciae (strain 3841) putative acetyltransferase Rhizobium leguminosarum bv. viciae
rhilw-b6a1y2 Rhizobium leguminosarum bv. trifolii (strains WSM2304\; WSM1325) Alpha\/beta hydrolase fold Rhizobium leguminosarum bv. trifolii
rhime-RA0724 Rhizobium meliloti (Sinorhizobium meliloti) putative hydrolase Sinorhizobium meliloti
rhisn-c3mdb6 Rhizobium sp. (strain NGR234) Putative hydrolase Rhizobium sp.
rhofd-q21vw5 Rhodoferax ferrireducens (strain DSM 15236 \/ ATCC BAA-621 \/ T118) alpha\/beta hydrolase Rhodoferax ferrireducens
rhopb-q218g8 Rhodopseudomonas palustris (strain BisB18) alpha\/beta hydrolase fold Rhodopseudomonas palustris
ricco-b9tm58 Ricinus communis (Castor bean) Valacyclovir hydrolase, putative Ricinus communis
sacen-a4ffy1 Saccharopolyspora erythraea (strain NRRL 23338) Hydrolase, alpha\/beta fold family Saccharopolyspora erythraea
salen-q75qq0 Salmonella enteritidis streptothricin acetyltransferase Salmonella enteritidis
salty-a1yjl0 Salmonella typhimurium, Salmonella choleraesuis, Salmonella enterica, Enterobacter cloacae, Proteus mirabilis Salmonella schwarzengrund, streptothricin acetyl-transferase Sat Salmonella typhimurium
serod-d1rs09 Serratia odorifera 4Rx13 Putative uncharacterized protein Serratia odorifera 4Rx13
serod-d4e633 Serratia odorifera DSM 4582 Carboxyl esterase Serratia odorifera DSM 4582
shiso-SAT Shigella sonnei Probable esterase\/lipase estX Shigella sonnei
silpo-q5lv17 Silicibacter pomeroyi hydrolase, alpha\/beta fold family Silicibacter pomeroyi
sinmw-a6ujk8 Sinorhizobium medicae (strain WSM419) (Ensifer medicae) Alpha\/beta hydrolase fold Sinorhizobium medicae
sphal-q1gqz1 Sphingopyxis alaskensis (Sphingomonas alaskensis) alpha\/beta hydrolase fold Sphingopyxis alaskensis
sphya-BpfD Sphingobium yanoikuyae (Sphingomonas yanoikuyae) HPHB to 4-hydroxybenzoate and 1,4-hydroquinone. Bisphenol F (BPF) degradation pathway BpfD Sphingobium yanoikuyae
stanl-d3pv31 Stackebrandtia nassauensis (strain DSM 44728 \/ NRRL B-16338 \/ NBR 102104 \/ LLR-40K-21) Alpha\/beta hydrolase fold protein Stackebrandtia nassauensis
stanl-d3q2z9 Stackebrandtia nassauensis (strain DSM 44728 \/ NRRL B-16338 \/ NBR 102104 \/ LLR-40K-21) Alpha\/beta hydrolase fold protein Stackebrandtia nassauensis
stanl-d3q4i5 Stackebrandtia nassauensis (strain DSM 44728 \/ NRRL B-16338 \/ NBR 102104 \/ LLR-40K-21) Alpha\/beta hydrolase fold protein Stackebrandtia nassauensis
stanl-d3q721 Stackebrandtia nassauensis (strain DSM 44728 \/ NRRL B-16338 \/ NBR 102104 \/ LLR-40K-21) Alpha\/beta hydrolase fold protein Stackebrandtia nassauensis
stiau-q09c32 Stigmatella aurantiaca DW4\/3-1 10-carbomethoxy-13-deoxycarminomycin esterase Stigmatella aurantiaca DW4\/3-1
stiau-q09e73 Stigmatella aurantiaca DW4\/3-1 10-carbomethoxy-13-deoxycarminomycin esterase Stigmatella aurantiaca DW4\/3-1
stram-a3ki49 Streptomyces ambofaciens ATCC 23877 Putative hydrolase or acyltransferase Streptomyces ambofaciens ATCC 23877
strco-SCM1.11 Streptomyces coelicolor SCM1.11 Streptomyces coelicolor
strgg-b1w150 Streptomyces griseus subsp. griseus (strain JCM 4626 \/ NBRC 13350) Putative hydrolase Streptomyces griseus subsp. griseus
strgg-b1w2r7 Streptomyces griseus subsp. griseus (strain JCM 4626 \/ NBRC 13350) Putative hydrolase Streptomyces griseus subsp. griseus
strpe-dnrP Streptomyces peucetius 10-carbomethoxy-13-deoxycarminomycin esterase (dnrP) gene Streptomyces peucetius
strpu-rdmC Streptomyces purpurascens ATCC 25489 aclacinomycin methylesterase RdmC (rdmC) Streptomyces purpurascens
strrd-d2arp5 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/ NI 9100) Alpha\/beta hydrolase fold protein Streptosporangium roseum
strrd-d2b0u2 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/ NI 9100) Carboxylesterase Streptosporangium roseum
strrd-d2b9n9 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/ NI 9100) Alpha\/beta hydrolase fold protein Streptosporangium roseum
strrd-d2bf33 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/ NI 9100) Hydrolase protein Streptosporangium roseum
strsp-dauP Streptomyces sp. (dauP) Rhodomycin D methylesterase DauP Streptomyces sp.
strsw-c9yxp4 Streptomyces scabies (Streptomyces scabiei)\; Streptomyces acidiscabies Putative hydrolase Streptomyces scabies
strsw-c9z486 Streptomyces scabies (strain 87.22) (Streptomyces scabiei) Putative hydrolase Streptomyces scabies
strub-b3vbe7 Streptococcus uberis RdmC Streptococcus uberis
theal-TA29 Thermoleophilum album YS-3 alpha\/beta hydrolase JDY09_02750 WDT94189 TA29 Thermoleophilum album
tryb2-q582c7 Trypanosoma brucei Trypanosoma brucei gambiense (strain MHOM\/CI\/86\/DAL972) hydrolase, alpha\/beta fold family, putative Trypanosoma brucei
tryb2-q582c8 Trypanosoma brucei Trypanosoma brucei gambiense (strain MHOM\/CI\/86\/DAL972) hydrolase, alpha\/beta fold family, putative Trypanosoma brucei
trycr-q4cq95 Trypanosoma cruzi hydrolase, alpha\/beta fold family, putative Trypanosoma cruzi
trycr-q4d8h9 Trypanosoma cruzi hydrolase, alpha\/beta fold family, putative Trypanosoma cruzi
trycr-q4d8i0 Trypanosoma cruzi hydrolase-like protein, putative Trypanosoma cruzi
uncba-Q9KIU0 uncultured bacterium esterase uncultured bacterium
varps-c5crm2 Variovorax paradoxus (strain S110) Alpha\/beta hydrolase fold protein Variovorax paradoxus
xenna-d3vf31 Xenorhabdus nematophila (strain ATCC 19061 \/ DSM 3370 \/ LMG 1036 \/ NCIB 9965 \/ AN6) Alpha\/beta hydrolase fold Xenorhabdus nematophila
yerbe-c4ryl6 Yersinia bercovieri ATCC 43970 Predicted hydrolase or acyltransferase (Alpha\/beta hydrolase superfamily) Yersinia bercovieri ATCC 43970
yeren-q29uc4 Yersinia enterocolitica streptothricin acetyl transferase Yersinia enterocolitica

Gene_locus_frgt Name Species
bacce-c2zrr8 Bacillus cereus (strains AH1273\; AH1272) Putative uncharacterized protein Bacillus cereus AH1273
strcl-b5gm73 Streptomyces clavuligerus ATCC 27064 10-carbomethoxy-13-deoxycarminomycin esterase Streptomyces clavuligerus ATCC 27064

Substrate Chemical Nomenclature Proteins
4-Hydroxyphenyl-4-hydroxybenzoate (4-hydroxyphenyl) 4-hydroxybenzoate sphya-BpfD
Aclacinomycin methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate strpu-rdmC
Aclarubicin methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate strpu-rdmC
BETEB bis(2-benzoyloxyethyl) benzene-1,4-dicarboxylate 9actn-h6wx58    thefu-q6a0i3    thefu-q6a0i4    9zzzz-Ple629    humin-cut    bacsu-pnbae    thefu-1831    fusso-cutas    clobh-A51055    clobh-A5I3I2    bruan-a0a6i0dyc0    exisa-c4l665    9gamm-QPI64981    9baci-a0a0b5kth6    alcbs-q0vqa3    alcbs-q0vq49    alcbs-q0vlq1    9gamm-k2gvb6    9gamm-u7i252    theal-TA21    theal-TA26    theal-TA29
BHET bis(2-hydroxyethyl) benzene-1,4-dicarboxylate idesa-peth    idesa-mheth    thefu-q6a0i3    thefu-q6a0i4    9flao-a0a330mq60    9flao-a0a0c1f4u8    9flao-kjj39608    9flao-a0a1m6f5v0    thefu-1831    fusso-cutas    9bact-EH0    theck-l0ef70    9arch-PET46    9flao-ChryBHETase    bacsu-pnbae    exiab-k0afs0    9bact-g9by57    thema-ESTA    9bact-a0a2h5z9r5    9flao-MarCE    strco-LIPA    9actn-a0a433e165    hydtt-d3dka9    9gamm-a0a1g6lje2    9baci-a0a0b5kth6    9arch-GuaPA    9bact-CHeMHETase    theal-TA21    theal-TA26    theal-TA29    9baci-gsBHETase
Josamycin [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate cytfi-mleCBF.1    brebn-c0z8w7    9bacl-mlePBB.1
Leucomycin-A1 [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate' 9cyan-OCA.1
Leucomycin-a5 [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] butanoate 9sphi-b5apj0    ecoli-estX
Midecamycin [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-4-(dimethylamino)-3-hydroxy-5-[(2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-propanoyloxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] propanoate brebn-c0z8w7    cytfi-mleCBF.1
Paranitrophenyl-octanoate (4-nitrophenyl) octanoate 9firm-a0a0a0ymq9    9bact-Q0GMU2    psesp-OPH    human-NOTUM    pseae-PA2949    crysp-Q874E9    emeni-q5b2c1    fusso-cutas    thite-g2rae6    9flao-a0a330mq60    9flao-a0a0c1f4u8    malgo-a8puy1    9bact-6EB3    partm-GthFAE    9bact-a0a2h5z9r5    9actn-j7k890    9actn-j7kdc6    fusox-a0a1d3s5h0    psesp-Est2    alcbs-q0vqa3    alcbs-q0vq49    alcbs-q0vlq1    9gamm-k2gvb6    9gamm-u7i252
Polycaprolactone Poly(hexano-6-lactone) fusso-cutas    aspor-cutas    humin-cut    9zzzz-A0A0G3FEJ8    9actn-SM14est    amymu-a0a0h3des9    9flao-a0a330mq60    9flao-a0a0c1f4u8    9flao-kjj39608    9flao-a0a1m6f5v0    9bact-g9by57    thecd-d1a9g5    psemy-a4xvf4    psemy-a4y035    pseol-e9kjl1    crysp-Q874E9    psecl-LIP1    psecl-LIP2    aspng-g9m5r3    mycua-a0pmc3    9basi-SiCut1    9basi-SiCut2    altal-Aacut10    pseae-llipa    alcbs-q0vqa3    alcbs-q0vq49    alcbs-q0vlq1    9gamm-k2gvb6    9gamm-u7i252    yarli-lip2
Polyethylene-terephthalate 2-methoxyethyl 4-acetylbenzoate idesa-peth    thefu-q6a0i4    9acto-f7ix06    9bact-g9by57    sacvd-c7mve8    thecd-d1a9g5    9actn-h6wx58    9zzzz-A0A0G3FEJ8    thefu-q6a0i3    9flao-a0a330mq60    9flao-a0a0c1f4u8    bacsu-pnbae    9zzzz-Ple628    9zzzz-Ple629    9firm-PHL7    9bact-c3ryl0    9gamm-PETaseMG8    olean-r4ykl9    morsp-lip1    vibga-a0a1z2siq1    vibga-a0a1m5fok3    pseol-e9kjl1    9gamm-PpelaLip    9psed-peh    9pseu-a0a1i6nu60    thecd-d1a2h1    9actn-a0a147kjy8    9bact-102Pee006    9cyan-305pEE028    9chlr-7QJM202    9bact-a0a656d8b6    fusso-cutas    thefu-1831    9actn-a0a1t4kk94    humin-cut    aspor-cutas    9burk-a0a1f4jxw8    9burk-PET11    thecs-711Erick    9actn-RII04304    9acto-d4q9n1    9gamm-a0a3l8bw54    9actn-a0a0n0my27    9burk-a0a1e4lw26    9actn-Alr407    9gamm-a0a3l8bdt3    9gamm-a0a2k9lit3    9actn-a0a0n0ney5    9actn-e9upm2    9arch-PET46    psea4-u2z2l5    9gamm-a0a031mkr8    9burk-a0a1w6l438    9psed-a0a078mgg8    9burk-a0a0g3bi90    9burk-a0a1w6l588    acide-PBSA    9baci-a0a090kq36    9baci-a0a0d0eil0    9baci-a0a090izy6    9baci-a0a090ivg8    9baci-a0a0d0ejv8    entcl-j7gkj7    9firm-a0a413uca3    9clot-a0a3r6ruf5    9firm-a0a4r3svb5    heyc2-f7z2k4    aciha-a0a1b1h4j8    micpa-PETase    kutbu-PETase    9bact-PetaseB1    9bact-PetaseB4    theal-TA21    theal-TA26    theal-TA29    9gamm-a0abn0jus0
Polylactic-acid 2-Hydroxypropanoic acid homopolymer paeam-PLAA    thefu-q6a0i3    rhopa-q6n9m9    alcbs-q0vlq1    9zzzz-A0A0G3FEJ8    9acto-f7ix06    crysp-Q874E9    9bact-a4uz14    9bact-a4uz10    psea2-s6bc01    thefu-q6a0i4    aspng-g9m5r3    psecl-LIP1    psecl-LIP2    psecl-LIP3    9bact-a4uz12    9zzzz-a0a0g3fj39    bacpu-q6rsn0    fusso-cutas    alcbs-q0vqa3    alcbs-q0vq49    9gamm-k2gvb6    9gamm-u7i252    theal-TA21
Rhodomycin-D methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate strsp-dauP    strpe-dnrP
Spiramycin 2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde brebn-c0z8w7    cytfi-mleCBF.1    9cyan-OCA.1    9cyan-OCB.1
Tildipirosin (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-piperidin-1-ylethyl)-15-(piperidin-1-ylmethyl)-1-oxacyclohexadeca-11,13-diene-2,10-dione 9sphi-b5apj0    ecoli-estX    bacce-q736x9    bacce-mleBCB.1    cytfi-mleCBF.1    paesp-mlePBA.1    brebn-c0z8w7    9cyan-OCA.1
Tilmicosin (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione 9sphi-b5apj0    ecoli-estX    bacce-q736x9    bacce-mleBCB.1    cytfi-mleCBF.1    paesp-mlePBA.1    brebn-c0z8w7    9cyan-OCA.1    9cyan-OCB.1
Tylosin 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde 9sphi-b5apj0    ecoli-estX    bacce-q736x9    bacce-mleBCB.1    9bacl-mlePBB.1    cytfi-mleCBF.1    paesp-mlePBA.1    brebn-c0z8w7    9cyan-a0a927enu2    9cyan-OCA.1    9cyan-OCB.1
Tylvalosin [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6R)-6-[[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetyloxy-16-ethyl-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate ecoli-estX    bacce-c2xlh1

Inhibitor Chemical Nomenclature Proteins
DCMAA (7S,9S)-7-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(4S,5R,6S)-4-hydroxy-6-methyl-5-[(2R,6R)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-9-ethyl-4,6,9-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione strpu-rdmC
DCMAT (7S,9S)-7-[(2R,4S,5S,6S)-4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-9-ethyl-4,6,9-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione strpu-rdmC

References (7)

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Gene_locus related to this paper: bacce-q736x9 , bacce-mleBCB.1 , 9bacl-mlePBB.1 , cytfi-mleCBF.1 , paesp-mlePBA.1 , brebn-c0z8w7

Title : The global distribution of the macrolide esterase EstX from the alpha\/beta hydrolase superfamily - Lin_2024_Commun.Biol_7_781
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Abstract :
PubMedSearch : Lin_2024_Commun.Biol_7_781
PubMedID: 38944651
Gene_locus related to this paper: ecoli-estX

Title : A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase - Dhindwal_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219827120
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PubMedSearch : Dhindwal_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2219827120
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Gene_locus related to this paper: 9sphi-b5apj0

Title : Biochemical and Structural Insights into Enzymatic Depolymerization of Polylactic Acid and Other Polyesters by Microbial Carboxylesterases - Hajighasemi_2016_Biomacromolecules_17_2027
Author(s) : Hajighasemi M , Nocek BP , Tchigvintsev A , Brown G , Flick R , Xu X , Cui H , Hai T , Joachimiak A , Golyshin PN , Savchenko A , Edwards EA , Yakunin AF
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Gene_locus related to this paper: marav-a1u5n0 , rhopa-q6n9m9 , alcbs-q0vlq1

Title : Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline - Ghosh_2009_J.Appl.Microbiol_106_1336
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Gene_locus related to this paper: 9sphi-b5apj0

Title : Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism - Jansson_2003_J.Biol.Chem_278_39006
Author(s) : Jansson A , Niemi J , Mantsala P , Schneider G
Ref : Journal of Biological Chemistry , 278 :39006 , 2003
Abstract :
PubMedSearch : Jansson_2003_J.Biol.Chem_278_39006
PubMedID: 12878604
Gene_locus related to this paper: ecoli-rdmC , strpu-rdmC

Title : Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens - Wang_2000_Biochim.Biophys.Acta_1480_191
Author(s) : Wang Y , Niemi J , Airas K , Ylihonko K , Hakala J , Mantsala P
Ref : Biochimica & Biophysica Acta , 1480 :191 , 2000
Abstract :
PubMedSearch : Wang_2000_Biochim.Biophys.Acta_1480_191
PubMedID: 11004563