Name : Human dipeptidyl peptidase VI in complex with a triazolopiperazine-based beta amino acid inhibitor

Revelation date : 06-Nov-2007

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Kowalchick, J.E., Leiting, B., Pryor, K.D., Marsilio, F., Wu, J.K., He, H., Lyons, K.A., Eiermann, G.J., Petrov, A., Scapin, G. et al.

Ligand : Inhibitor Triazolopiperazine-based-beta-amino-acid Ligand in structure: Ligplot

References (1)

Title : Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors - Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
Author(s) : Kowalchick JE , Leiting B , Pryor KD , Marsilio F , Wu JK , He H , Lyons KA , Eiermann GJ , Petrov A , Scapin G , Patel RA , Thornberry NA , Weber AE , Kim D
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5934 , 2007
Abstract :
PubMedSearch : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934
PubMedID: 17827003
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2QOE Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2QOE Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2QOE Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2QOE 3D, interactive encyclopedia of proteins - PROTEOPEDIA server