Name : Structure of DPPIV in complex with substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl inhibitor

Revelation date : 18-Mar-2008

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Corbett, J.W., Dirico, K., Song, W., Boscoe, B.P., Doran, S.D., Boyer, D., Qiu, X., Ammirati, M., Vanvolkenburg, M.A., McPherson, R.K., Parker, J.C., Cox, E.D.

Ligand : Inhibitor cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl-34Q Ligand in structure: Ligplot

References (1)

Title : Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors - Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
Author(s) : Corbett JW , Dirico K , Song W , Boscoe BP , Doran SD , Boyer D , Qiu X , Ammirati M , VanVolkenburg MA , McPherson RK , Parker JC , Cox ED
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :6707 , 2007
Abstract :
PubMedSearch : Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
PubMedID: 17977724
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2RIP Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2RIP Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2RIP Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2RIP 3D, interactive encyclopedia of proteins - PROTEOPEDIA server