Corbett_2007_Bioorg.Med.Chem.Lett_17_6707

Reference

Title : Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors - Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
Author(s) : Corbett JW , Dirico K , Song W , Boscoe BP , Doran SD , Boyer D , Qiu X , Ammirati M , VanVolkenburg MA , McPherson RK , Parker JC , Cox ED
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :6707 , 2007
Abstract :

The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single digit DPP-IV inhibitor 53 exhibited a preferred PK/PD profile in preclinical animal models and was selected for additional profiling.

PubMedSearch : Corbett_2007_Bioorg.Med.Chem.Lett_17_6707
PubMedID: 17977724
Gene_locus related to this paper: human-DPP4

Citations formats

Corbett JW, Dirico K, Song W, Boscoe BP, Doran SD, Boyer D, Qiu X, Ammirati M, VanVolkenburg MA, McPherson RK, Parker JC, Cox ED (2007)
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Bioorganic & Medicinal Chemistry Lett 17 :6707

Corbett JW, Dirico K, Song W, Boscoe BP, Doran SD, Boyer D, Qiu X, Ammirati M, VanVolkenburg MA, McPherson RK, Parker JC, Cox ED (2007)
Bioorganic & Medicinal Chemistry Lett 17 :6707