3NOX

Name : Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone

Revelation date : 11-Aug-2010

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
"Meng, W., Brigance, R.P., Chao, H.J., Fura, A., Harrity, T., Marcinkeviciene, J., O`Connor, S.P., Tamura, J.K., Xie, D., Zhang, Y., Klei, H.E., Kish, K., Weigelt, C.A., Turdi, H., Wang, A., Zahler, R., Kirby, M., Hamann, L.G."

Ligand :

References (1)

Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620
Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG
Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010
Abstract : Meng_2010_J.Med.Chem_53_5620
ESTHER : Meng_2010_J.Med.Chem_53_5620
PubMedSearch : Meng_2010_J.Med.Chem_53_5620
PubMedID: 20684603
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

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