3NOX
Name : Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Revelation date : 11-Aug-2010
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP4
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Meng, W., Brigance, R.P., Chao, H.J., Fura, A., Harrity, T., Marcinkeviciene, J., O`Connor, S.P., Tamura, J.K., Xie, D., Zhang, Y., Klei, H.E., Kish, K., Weigelt, C.A., Turdi, H., Wang, A., Zahler, R., Kirby, M., Hamann, L.G.
Ligand : Inhibitor CHEMBL1214943 Ligand in structure: Ligplot
References (1)
| Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620 |
| Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG |
| Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010 |
| Abstract : |
| PubMedSearch : Meng_2010_J.Med.Chem_53_5620 |
| PubMedID: 20684603 |
| Gene_locus related to this paper: human-DPP4 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 3NOX Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 3NOX Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 3NOX Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 3NOX 3D, interactive encyclopedia of proteins - PROTEOPEDIA server