3Q0T
Name : Crystal structure of human dpp-IV in complex with SA-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5H-pyrrolo[3,4-B]pyridin-6(7H)-yl)acetate
Revelation date : 29-Feb-2012
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP4
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Wang, W., Devasthale, P., Wang, A., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Sun, L., Levesque, P., Zahler, R., Kirby, M., Hamann, L.G.
Ligand : Inhibitor CHEMBL1910111 Ligand in structure: Ligplot
References (1)
| Title : Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors - Meng_2010_J.Med.Chem_53_5620 |
| Author(s) : Meng W , Brigance RP , Chao HJ , Fura A , Harrity T , Marcinkeviciene J , O'Connor SP , Tamura JK , Xie D , Zhang Y , Klei HE , Kish K , Weigelt CA , Turdi H , Wang A , Zahler R , Kirby MS , Hamann LG |
| Ref : Journal of Medicinal Chemistry , 53 :5620 , 2010 |
| Abstract : |
| PubMedSearch : Meng_2010_J.Med.Chem_53_5620 |
| PubMedID: 20684603 |
| Gene_locus related to this paper: human-DPP4 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 3Q0T Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 3Q0T Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 3Q0T Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 3Q0T 3D, interactive encyclopedia of proteins - PROTEOPEDIA server