3VJM

Name : Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex witha prolylthiazolidine inhibitor 1

Revelation date : 15-Aug-2012

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.

Ligand :

References (3)

Title : Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group - Yoshida_2012_Bioorg.Med.Chem_20_5033
Author(s) : Yoshida T , Akahoshi F , Sakashita H , Sonda S , Takeuchi M , Tanaka Y , Nabeno M , Kishida H , Miyaguchi I , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry , 20 :5033 , 2012
PubMedID: 22824762
Gene_locus related to this paper: human-DPP4

Title : [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors - Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618
Author(s) : Yoshida T , Sakashita H , Akahoshi F , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2618 , 2007
PubMedID: 17317162
Gene_locus related to this paper: human-DPP4

Title : [(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors - Sakashita_2006_Bioorg.Med.Chem_14_3662
Author(s) : Sakashita H , Akahoshi F , Kitajima H , Tsutsumiuchi R , Hayashi Y
Ref : Bioorganic & Medicinal Chemistry , 14 :3662 , 2006
PubMedID: 16460948
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 3VJM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3VJM Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3VJM Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3VJM 3D, interactive encyclopedia of proteins - PROTEOPEDIA server