4JNC

Name : Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor

Revelation date : 05-Jun-2013

Family : Epoxide_hydrolase

Gene_locus : human-EPHX2

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Thalji, R.K., McAtee, J.J., Belyanskaya, S., Brandt, M., Brown, G.D., Costell, M.H., Ding, Y., Dodson, J.W., Eisennagel, S.H., Fries, R.E., Gross, J.W., Harpel, M.R., Holt, D.A., Israel, D.I., Jolivette, L.J., Krosky, D., Li, H., Lu, Q., Mandichak, T., Roethke, T., Schnackenberg, C.G., Schwartz, B., Shewchuk, L.M., Xie, W., Behm, D.J., Douglas, S.A., Shaw, A.L., Marino, J.P.

Ligand : Inhibitor CHEMBL2392714 Ligand in structure: Ligplot

References (1)

Title : Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase - Thalji_2013_Bioorg.Med.Chem.Lett_23_3584
Author(s) : Thalji RK , McAtee JJ , Belyanskaya S , Brandt M , Brown GD , Costell MH , Ding Y , Dodson JW , Eisennagel SH , Fries RE , Gross JW , Harpel MR , Holt DA , Israel DI , Jolivette LJ , Krosky D , Li H , Lu Q , Mandichak T , Roethke T , Schnackenberg CG , Schwartz B , Shewchuk LM , Xie W , Behm DJ , Douglas SA , Shaw AL , Marino JP, Jr.
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3584 , 2013
Abstract :
PubMedSearch : Thalji_2013_Bioorg.Med.Chem.Lett_23_3584
PubMedID: 23664879
Gene_locus related to this paper: human-EPHX2

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 4JNC Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 4JNC Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 4JNC Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 4JNC 3D, interactive encyclopedia of proteins - PROTEOPEDIA server