9GCQ
Name : Human Butyrylcholinesterase in complex with N1,N1-dimethyl-N2-(6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-yl)ethane-1,2-diamine. Multitarget p38-MAPK-inhibitor BChE
Revelation date : 13-Aug-2025
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Brazzolotto, X.,Meden, A.,Knez, D.,Gobec, S.,Nachon, F.
References (1)
| Title : Dual Inhibitors of p38alpha Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction - Knez_2026_J.Med.Chem_69_19891 |
| Author(s) : Knez D , Malinak D , Meden A , Ferjancic Benetik S , Pislar A , Kohoutova Z , Vondrackova I , Psotka M , Lycka A , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Dias J , Nachon F , Detka J , Targosinski F , Hliabovich D , Brunzelle JS , Shuvalova L , Salat K , Roy SM , Watterson DM , Musilek K , Gobec S |
| Ref : Journal of Medicinal Chemistry , 69 :19891 , 2026 |
| Abstract : |
| PubMedSearch : Knez_2026_J.Med.Chem_69_19891 |
| PubMedID: 42679157 |
| Gene_locus related to this paper: human-BCHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9GCQ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9GCQ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9GCQ Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9GCQ 3D, interactive encyclopedia of proteins - PROTEOPEDIA server