9JFM
Name : Co-crystal Structure of sEH with tetrahydroberberine derivative ((R)-14i inhibitor-19 A1EBK)
Revelation date : 10-Sep-2025
Family : Epoxide_hydrolase
Gene_locus : human-EPHX2
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Wang, H., Feng, Y., Du, X.Y.
Ligand : Inhibitor sEH-inhibitor-19 Ligand in structure: Ligplot
References (3)
| Title : Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy - Liu_2024_J.Med.Chem__ |
| Author(s) : Liu XZ , Du XY , Xie WS , Ding J , Zhu MZ , Feng ZQ , Wang H , Feng Y , Yu MJ , Liu SM , Liu WT , Zhu XH , Liang JH |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_J.Med.Chem__ |
| PubMedID: 39658523 |
| Title : Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy - Liu_2024_J.Med.Chem__ |
| Author(s) : Liu XZ , Du XY , Xie WS , Ding J , Zhu MZ , Feng ZQ , Wang H , Feng Y , Yu MJ , Liu SM , Liu WT , Zhu XH , Liang JH |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_J.Med.Chem__ |
| PubMedID: 39658523 |
| Title : Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy - Liu_2024_J.Med.Chem__ |
| Author(s) : Liu XZ , Du XY , Xie WS , Ding J , Zhu MZ , Feng ZQ , Wang H , Feng Y , Yu MJ , Liu SM , Liu WT , Zhu XH , Liang JH |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_J.Med.Chem__ |
| PubMedID: 39658523 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9JFM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9JFM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9JFM Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9JFM 3D, interactive encyclopedia of proteins - PROTEOPEDIA server