9MD8
Name : Structure of the Mycobacterium tuberculosis serine hydrolase, Hip1 complex with inhibitor 2 (Hip1-2) via Ser228
Revelation date : 17-Dec-2025
Family : Tiancimycin-TnmK-Tripeptidase-HIP
Gene_locus : myctu-ym24
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Yim, M.K.,Olsen, K.J.,Brooks, C.L.,Pena, K.J.,Johnson, S.J.,Goldfarb, N.E.
References (3)
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9MD8 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9MD8 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9MD8 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9MD8 3D, interactive encyclopedia of proteins - PROTEOPEDIA server