myctu-ym24
Mycobacterium tuberculosis, Mycobacterium bovis Carboxylesterase A, caeA, rv2224c MT2282, Hydrolase important for pathogenesis 1 (Hip1)
Comment
Hydrolase important for pathogenesis 1 (Hip1, rv2224c). Serine protease that promotes tuberculosis (TB) pathogenesis by promoting the processing and the extracellular release of the M.tuberculosis (Mtb) heat-shock protein GroEL2. In vitro, catalyzes the cleavage of ester bonds. Esterase activity increases with increasing carbon chain length of the substrate. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains.
Relationship
Family : Tiancimycin-TnmK-Tripeptidase-HIP
Block : X
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EMolecular evidence
Sequence
Peptide
MGMRLSRRDK IARMLLIWAA LAAVALVLVG CIRVVGGRAR MAEPKLGQPV EWTPCRSSNP QVKIPGGALC GKLAVPVDYD RPDGDVAALA LIRFPATGDK IGSLVINPGG PGESGIEAAL GVFQTLPKRV HERFDLVGFD PRGVASSRPA IWCNSDADND RLRAEPQVDY SREGVAHIEN ETKQFVGRCV DKMGKNFLAH VGTVNVAKDL DAIRAALGDD KLTYLGYSYG TRIGSAYAEE FPQRVRAMIL DGAVDPNADP IEAELRQAKG FQDAFNNYAA DCAKNAGCPL GADPAKAVEV YHSLVDPLVD PDNPRISRPA RTKDPRGLSY SDAIVGTIMA LYSPNLWQHL TDGLSELVDN RGDTLLALAD MYMRRDSHGR YNNSGDARVA INCVDQPPVT DRDKVIDEDR RAREIAPFMS YGKFTGDAPL GTCAFWPVPP TSQPHAVSAP GLVPTVVVST THDPATPYKA GVDLANQLRG SLLTFDGTQH TVVFQGDSCI DEYVTAYLIG GTTPPSGAKC
References (19)
| Title : 2.1 A crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1) - Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| Author(s) : Brooks CL , Ostrov DA , Schumann NC , Kakkad S , Li D , Pena K , Williams BP , Goldfarb NE |
| Ref : Biochemical & Biophysical Research Communications , 630 :57 , 2022 |
| Abstract : |
| PubMedSearch : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
| PubMedID: 36148729 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis - Babin_2021_ACS.Cent.Sci_7_803 |
| Author(s) : Babin BM , Fernandez-Cuervo G , Sheng J , Green O , Ordonez AA , Turner ML , Keller LJ , Jain SK , Shabat D , Bogyo M |
| Ref : ACS Cent Sci , 7 :803 , 2021 |
| Abstract : |
| PubMedSearch : Babin_2021_ACS.Cent.Sci_7_803 |
| PubMedID: 34079897 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses - Georgieva_2018_Infect.Immun_86_ |
| Author(s) : Georgieva M , Sia JK , Bizzell E , Madan-Lala R , Rengarajan J |
| Ref : Infect Immun , 86 : , 2018 |
| Abstract : |
| PubMedSearch : Georgieva_2018_Infect.Immun_86_ |
| PubMedID: 29133346 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Deletion of BCG Hip1 protease enhances dendritic cell and CD4 T cell responses - Bizzell_2018_J.Leukoc.Biol_103_739 |
| Author(s) : Bizzell E , Sia JK , Quezada M , Enriquez A , Georgieva M , Rengarajan J |
| Ref : J Leukoc Biol , 103 :739 , 2018 |
| Abstract : |
| PubMedSearch : Bizzell_2018_J.Leukoc.Biol_103_739 |
| PubMedID: 29345365 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) - Naffin-Olivos_2017_Biochemistry_56_2304 |
| Author(s) : Naffin-Olivos JL , Daab A , White A , Goldfarb NE , Milne AC , Liu D , Baikovitz J , Dunn BM , Rengarajan J , Petsko GA , Ringe D |
| Ref : Biochemistry , 56 :2304 , 2017 |
| Abstract : |
| PubMedSearch : Naffin-Olivos_2017_Biochemistry_56_2304 |
| PubMedID: 28346784 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis - Tallman_2016_ACS.Infect.Dis_2_936 |
| Author(s) : Tallman KR , Levine SR , Beatty KE |
| Ref : ACS Infect Dis , 2 :936 , 2016 |
| Abstract : |
| PubMedSearch : Tallman_2016_ACS.Infect.Dis_2_936 |
| PubMedID: 27690385 |
| Gene_locus related to this paper: myctu-rv0183 , myctu-Rv1399c , myctu-RV1683 , myctu-Rv2284 , myctu-Rv2970c , myctu-ym24 |
| Title : Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis - Lentz_2016_ACS.Infect.Dis_2_807 |
| Author(s) : Lentz CS , Ordonez AA , Kasperkiewicz P , La Greca F , O'Donoghue AJ , Schulze CJ , Powers JC , Craik CS , Drag M , Jain SK , Bogyo M |
| Ref : ACS Infect Dis , 2 :807 , 2016 |
| Abstract : |
| PubMedSearch : Lentz_2016_ACS.Infect.Dis_2_807 |
| PubMedID: 27739665 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2 - Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| Author(s) : Naffin-Olivos JL , Georgieva M , Goldfarb N , Madan-Lala R , Dong L , Bizzell E , Valinetz E , Brandt GS , Yu S , Shabashvili DE , Ringe D , Dunn BM , Petsko GA , Rengarajan J |
| Ref : PLoS Pathog , 10 :e1004132 , 2014 |
| Abstract : |
| PubMedSearch : Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| PubMedID: 24830429 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1 - Madan-Lala_2014_J.Immunol_192_4263 |
| Author(s) : Madan-Lala R , Sia JK , King R , Adekambi T , Monin L , Khader SA , Pulendran B , Rengarajan J |
| Ref : J Immunol , 192 :4263 , 2014 |
| Abstract : |
| PubMedSearch : Madan-Lala_2014_J.Immunol_192_4263 |
| PubMedID: 24659689 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation - Madan-Lala_2011_Infect.Immun_79_4828 |
| Author(s) : Madan-Lala R , Peixoto KV , Re F , Rengarajan J |
| Ref : Infect Immun , 79 :4828 , 2011 |
| Abstract : |
| PubMedSearch : Madan-Lala_2011_Infect.Immun_79_4828 |
| PubMedID: 21947769 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment - Vandal_2009_J.Bacteriol_191_625 |
| Author(s) : Vandal OH , Roberts JA , Odaira T , Schnappinger D , Nathan CF , Ehrt S |
| Ref : Journal of Bacteriology , 191 :625 , 2009 |
| Abstract : |
| PubMedSearch : Vandal_2009_J.Bacteriol_191_625 |
| PubMedID: 19011036 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis Rv2224c modulates innate immune responses - Rengarajan_2008_Proc.Natl.Acad.Sci.U.S.A_105_264 |
| Author(s) : Rengarajan J , Murphy E , Park A , Krone CL , Hett EC , Bloom BR , Glimcher LH , Rubin EJ |
| Ref : Proc Natl Acad Sci U S A , 105 :264 , 2008 |
| Abstract : |
| PubMedSearch : Rengarajan_2008_Proc.Natl.Acad.Sci.U.S.A_105_264 |
| PubMedID: 18172199 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis - Lun_2007_J.Biol.Chem_282_18348 |
| Author(s) : Lun S , Bishai WR |
| Ref : Journal of Biological Chemistry , 282 :18348 , 2007 |
| Abstract : |
| PubMedSearch : Lun_2007_J.Biol.Chem_282_18348 |
| PubMedID: 17428787 |
| Gene_locus related to this paper: myctu-ym23 , myctu-ym24 |