Tiancimycin-TnmK-Tripeptidase-HIP

Relationship

Family: Tiancimycin-TnmK-Tripeptidase-HIP

Block: X

Parent Family: No family

Comment

Tnmk1 enzymes responsible for the C-C bond formation linking the anthraquinone moiety and enediyne core together in tiancimycin (TNM) biosynthesis. The anthraquinone-fused enediyne (AFE) are a class of DNA-cleaving bacterial natural products composed of a DNA-intercalating anthraquinone moiety and a 10-membered enediyne warhead. AFE are used to produce AFE-based antibody-drug conjugates. The family contains also members of other gene products included in different biosynthetic gene clusters (BGC) and polyketide synthases (PKS) including UcmK1, and DynA4. TnmK1 shares significant homology with proteases including the serine protease Hip1 (Hydrolase important for pathogenesis) from Mycobacterium tuberculosis now included in this family. All bacterial sequences. Fungi sequences might be due to horizontal transfer.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
8G5U Crystal structure of TnmK2 complexed with TNM B Tiancimycin-B strsp-TnmK2
8G5T Crystal structure of apo TnmK2 strsp-TnmK2
8E18 Crystal structure of apo TnmK1 strsp-TnmK1
8E19 Crystal structure of apo TnmK1-8 complex TNM-H Tiancimycin-H strsp-TnmK1
8E5W 2.1 angstrom crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1). dehydroalanine Hip1 myctu-ym24
7SFM Crystal Structure of Mycobacterium tuberculosis Hip1 (Rv2224c) hydrolase important for pathogenesis. A newer entry is available 8E5W myctu-ym24
7M7C Crystal Structure of Mycobacterium tuberculosis Hip1 (Rv2224c) mutant - T466A\/S228DHA (dehydroalanine) myctu-ym24
5BKM Crystal Structure of Mycobacterium tuberculosis Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine) myctu-ym24
5UGQ Crystal Structure of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) myctu-ym24
5UNO Crystal Structure of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) myctu-ym24
5UOH Crystal Structure of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) T466A mutant myctu-ym24

Gene_locus Name Species
frasn-A8L713 Frankia sp. EAN1pec alpha\/beta hydrolase fold precursor Frankia sp. EAN1pec
9acto-q67g34 Streptomyces griseoruber putative secreted tripeptidylaminopeptidase Streptomyces griseoruber
9acto-q841m4 Streptomyces griseochromogenes putative secreted peptidase Streptomyces griseochromogenes
acic1-a0lqy2 Acidothermus cellulolyticus (strain ATCC 43068 \/ 11B) Tripeptidyl-peptidase B Acidothermus cellulolyticus
agrtu-ATU2171 Agrobacterium tumefaciens (strain C58 \/ ATCC 33970) hydrolase Agrobacterium tumefaciens
arts2-a0jsu3 Arthrobacter sp. (strain FB24) Tripeptidyl-peptidase B, Serine peptidase, MEROPS family S33 Arthrobacter sp.
coref-CE1275 Corynebacterium efficiens conserved hypothetical protein Corynebacterium efficiens
corgl-CGL1178 Corynebacterium glutamicum (Brevibacterium flavum) AlphaBeta_hydrolase superfamily) Corynebacterium glutamicum
ecoli-yuar Escherichia coli hypothetical 55.7 kda protein in ompp-int intergenic region precursor Escherichia coli
ecoli-Z1930 Escherichia coli YuaR YmcE protein putative protease encoded within prophage CP-933X Escherichia coli
emeni-q5asf9 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
frasc-q2jaj3 Frankia sp. (strain CcI3) putative protease precursor Frankia sp. CcI3
gibze-q4il01 Gibberella zeae (Fusarium graminearum) hypothetical protein Gibberella zeae
kinra-q412z7 Kineococcus radiotolerans SRS30216 alpha\/beta hydrolase fold precursor Kineococcus radiotolerans SRS30216
kinrd-a6w7k9 Kineococcus radiotolerans (strain ATCC BAA-149 \/ DSM 14245 \/ SRS30216) alpha\/beta hydrolase fold Kineococcus radiotolerans SRS30216
leixx-q6agt3 Leifsonia xyli (subsp. xyli) peptidase Leifsonia xyli
mycgi-a4tbn0 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., alpha\/beta hydrolase fold Mycobacterium gilvum PYR-GCK
mycgi-a4tbn2 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., prolyl oligopeptidase, alpha\/beta hydrolase fold precursor Mycobacterium gilvum PYR-GCK
mycle-ML1632 Mycobacterium leprae possible hydrolase Mycobacterium leprae
mycle-ML1633 Mycobacterium leprae possible secreted hydrolase Mycobacterium leprae
mycpa-q73yi8 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein Mycobacterium paratuberculosis
mycpa-q73yi9 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein Mycobacterium paratuberculosis
mycs2-a0r084 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Hydrolase, alpha\/beta fold family protein Mycobacterium smegmatis
mycs2-a0r085 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Protease Mycobacterium smegmatis
mycss-q1b6p7 Mycobacterium sp. JLS and KMS alpha\/beta hydrolase fold Mycobacterium sp. JLS
mycss-q1b6p8 Mycobacterium sp. KMS and JLS alpha\/beta hydrolase fold Mycobacterium sp. JLS
myctu-ym23 Mycobacterium tuberculosis Mycobacterium bovis hypothetical 55.1 kda protein MT2281 rv2223c caeB precursor Mycobacterium tuberculosis
myctu-ym24 Mycobacterium tuberculosis, Mycobacterium bovis Carboxylesterase A, caeA, rv2224c MT2282, Hydrolase important for pathogenesis 1 (Hip1) Mycobacterium tuberculosis
mycua-a0png7 Mycobacterium ulcerans (strain Agy99) Exported protease Mycobacterium ulcerans
mycua-a0png9 Mycobacterium ulcerans (strain Agy99) Exported protease Mycobacterium ulcerans
mycvn-q25wu1 Mycobacterium vanbaalenii PYR-1 alpha\/beta hydrolase fold precursor Mycobacterium vanbaalenii PYR-1
mycvn-q25wu2 Mycobacterium vanbaalenii PYR-1 alpha\/beta hydrolase fold precursor Mycobacterium vanbaalenii PYR-1
nocfa-q5yn81 Nocardia farcinica putative hydrolase Nocardia farcinica
nocfa-q5yz86 Nocardia farcinica putative hydrolase Nocardia farcinica
nocfa-q5z339 Nocardia farcinica putative hydrolase Nocardia farcinica
nocsj-a1sdp6 Nocardioides sp. (strain BAA-499 \/ JS614) alpha\/beta hydrolase fold precursor Nocardioides sp. JS614
phopr-q1yx74 Photobacterium profundum 3TCK (Photobacterium sp. (strain SS9)) hypothetical protein Photobacterium profundum
proac-q6ab58 Propionibacterium acnes putative hydrolase Propionibacterium acnes
sacd2-q21n23 Saccharophagus degradans (strain 2-40 \/ ATCC 43961 \/ DSM 17024) hypothetical protein precursor Saccharophagus degradans
stram-q1rql3 Streptomyces ambofaciens ATCC 23877 putative hydrolase Streptomyces ambofaciens ATCC 23877
strav-SAV888 Streptomyces avermitilis putative hydrolase Streptomyces avermitilis
strav-SAV906 Streptomyces avermitilis putative hydrolase Streptomyces avermitilis
strav-SAV1231 Streptomyces avermitilis putative protease Streptomyces avermitilis
strav-SAV1906 Streptomyces avermitilis (strain ATCC 31267 \/ DSM 46492 \/ JCM 5070 \/ NCIMB 12804 \/ NRRL 8165 \/ MA-4680) putative secreted peptidase Streptomyces avermitilis
strav-SAV3080 Streptomyces avermitilis hypothetical protein Streptomyces avermitilis
strav-SAV3081 Streptomyces avermitilis hypothetical protein Streptomyces avermitilis
strav-SAV7110 Streptomyces avermitilis putative secreted tripeptidylaminopeptidase Streptomyces avermitilis
strav-SLPD Streptomyces avermitilis (strain ATCC 31267 \/ DSM 46492 \/ JCM 5070 \/ NCIMB 12804 \/ NRRL 8165 \/ MA-4680) hypothetical protein slpd Streptomyces avermitilis
strco-2SC3B6.03C Streptomyces coelicolor peptidase Streptomyces coelicolor
strco-2SC3B6.04C Streptomyces coelicolor putative peptidase Streptomyces coelicolor
strco-SC1B5.03C Streptomyces coelicolor putative secreted protease Streptomyces coelicolor
strco-SC5H1.36 Streptomyces coelicolor putative protease Streptomyces coelicolor
strco-SC9C7.15C Streptomyces coelicolor putative secreted peptidase Streptomyces coelicolor
strco-SC10F4.23 Streptomyces coelicolor, Streptomyces lividans, putative secreted hydrolase Streptomyces coelicolor
strco-SCD8A.14C Streptomyces coelicolor hypothetical 56.8 kda protein Streptomyces coelicolor
strco-SCO2516 Streptomyces coelicolor putative secreted protein Streptomyces coelicolor
strco-SLPD Streptomyces lividans, and Streptomyces coelicolor proteinase Streptomyces lividans
strco-TAP Streptomyces coelicolor, Streptomyces lividans, putative secreted tripeptidylaminopeptidase Streptomyces coelicolor
strgl-q45fc4 Streptomyces globisporus prx. Putative proteinase gene is involved in regulation of landomycin E biosynthesis Streptomyces globisporus
strli-SLPE Streptomyces lividans proteinase Streptomyces lividans
synsc-q3ahc2 Synechococcus sp. (strain CC9605) putative protease precursor Synechococcus sp.
thefy-q47l59 Thermobifida fusca (strain YX) hypothetical protein Thermobifida fusca
thefy-q47rx9 Thermobifida fusca (strain YX) putative secreted peptidase precursor Thermobifida fusca
trowh-TWT693 Tropheryma whipplei (Whipple's bacillus) peptidase Tropheryma whipplei
serp5-a8geh7 Serratia proteamaculans (strain 568). TAP domain protein Serratia proteamaculans
9actn-a0a011akt9 Cryptosporangium arvum DSM 44712. TAP-like protein Cryptosporangium arvum DSM 44712
9actn-a0a022mml3 Streptomyces sp. Tu 6176. Hydrolase Streptomyces sp. Tu 6176
9actn-a0a066z9p4 Kitasatospora cheerisanensis KCTC 2395. Alpha\/beta hydrolase Kitasatospora cheerisanensis KCTC 2395
9actn-a0a0a8f096 Streptomyces sp. 769. TAP domain protein Streptomyces sp. 769
kitgr-a0a0d0pn85 Kitasatospora griseola (Streptomyces griseolosporeus). Hydrolase Kitasatospora griseola
9actn-a0a0f0gvf0 Streptomyces sp. NRRL F-4428. Hydrolase Streptomyces sp. NRRL F-4428
9actn-a0a0f0hih6 Streptomyces sp. NRRL F-4428. Hydrolase Streptomyces sp. NRRL F-4428
9actn-a0a0f7fze8 Streptomyces xiamenensis. Hydrolase, alpha\/beta domain protein Streptomyces xiamenensis
9actn-a0a0g3ujm9 Streptomyces sp. Mg1. Surfactin hydrolase Streptomyces sp. Mg1
9actn-a0a0h4c1q3 Streptomyces sp. PBH53. Hydrolase Streptomyces sp. PBH53
9actn-a0a0j6xrr3 Streptomyces roseus. Hydrolase Streptomyces roseus
9actn-a0a0k9xhw8 Streptomyces caatingaensis. Hydrolase Streptomyces caatingaensis
9actn-a0a0k9xkj1 Streptomyces caatingaensis. Hydrolase Streptomyces caatingaensis
9actn-a0a0l0jxh3 Streptomyces acidiscabies. Hydrolase Streptomyces acidiscabies
9actn-a0a0l8qx05 Streptomyces varsoviensis. Hydrolase Streptomyces varsoviensis
9actn-a0a0m8w9j9 Streptomyces sp. NRRL WC-3618. Hydrolase Streptomyces sp. NRRL WC-3618
9actn-a0a0m8y399 Streptomyces sp. NRRL F-6491. Hydrolase Streptomyces sp. NRRL F-6491
9actn-a0a0n0mxs6 Actinobacteria bacterium OK074. TAP domain protein Actinobacteria bacterium OK074
9actn-a0a0n0sfq4 Streptomyces sp. WM4235. Hydrolase Streptomyces sp. WM4235
9actn-a0a0n0xx59 Streptomyces chattanoogensis. Hydrolase Streptomyces chattanoogensis
9pseu-a0a0n9i2y8 Kibdelosporangium phytohabitans. AB hydrolase-1 domain-containing protein Kibdelosporangium phytohabitans
9pseu-a0a0n9icl8 Kibdelosporangium phytohabitans. Alpha\/beta hydrolase Kibdelosporangium phytohabitans
9actn-a0a0u3g765 Streptomyces sp. CdTB01. Hydrolase Streptomyces sp. CdTB01
9actn-a0a0w7xbu0 Streptomyces silvensis. Hydrolase Streptomyces silvensis
strvo-a0a0x3vmv2 Streptomyces violaceusniger. Hydrolase Streptomyces violaceusniger
9actn-a0a0x3w7u0 Streptomyces sp. NRRL S-1521. Hydrolase Streptomyces sp. NRRL S-1521
9actn-a0a100y8r6 Streptomyces kanasensis. Hydrolase Streptomyces kanasensis
9actn-a0a101nl05 Streptomyces cellostaticus. Hydrolase Streptomyces cellostaticus
9actn-a0a101nlg7 Streptomyces cellostaticus. Hydrolase Streptomyces cellostaticus
9actn-a0a117p5h1 Streptomyces curacoi. Hydrolase Streptomyces curacoi
9actn-a0a117pyy8 Streptomyces yokosukanensis. Hydrolase Streptomyces yokosukanensis
9actn-a0a124gyx7 Streptomyces curacoi. Hydrolase Streptomyces curacoi
strsp-TnmK1 Streptomyces sp. CB03234. Secreted hydrolase Streptomyces sp. CB03234
strsp-TnmK2 Streptomyces sp. CB03234. Secreted hydrolase Streptomyces sp. CB03234
9actn-a0a132mvw4 Carbonactinospora thermoautotrophica. TAP domain protein Carbonactinospora thermoautotrophica
strun-UcmK2 Streptomyces uncialis. Hydrolase Streptomyces uncialis
9noca-a0a164i9m6 Nocardia terpenica. Transporter Nocardia terpenica
9actn-a0a176l059 Streptomyces sp. FXJ1.172. Hydrolase Streptomyces sp. FXJ1.172
9actn-a0a1b1b151 Streptomyces griseochromogenes. Hydrolase Streptomyces griseochromogenes
9actn-a0a1b1bd71 Streptomyces griseochromogenes. Hydrolase Streptomyces griseochromogenes
9actn-a0a1b9ery4 Streptomyces sp. PTY087I2. Tripeptidyl aminopeptidase Streptomyces sp. PTY087I2
9actn-a0a1c4hwr3 Streptomyces sp. DvalAA-43. Alpha\/beta hydrolase fold Streptomyces sp. DvalAA-43
9actn-a0a1c5edq7 Streptomyces sp. Ncost-T10-10d. TAP-like protein Streptomyces sp. Ncost-T10-10d
micya-YpmK1 Micromonospora yangpuensis. TAP-like protein YpmK1 Micromonospora yangpuensis
micya-YpmK2 Micromonospora yangpuensis. Alpha\/beta hydrolase fold YpmK2 Micromonospora yangpuensis
9actn-a0a1d2i9x0 Streptomyces sp. AVP053U2. Tripeptidyl aminopeptidase Streptomyces sp. AVP053U2
strov-a0a1d8srt6 Streptomyces olivaceus. Hydrolase Streptomyces olivaceus
9actn-a0a1e5p269 Streptomyces agglomeratus. Hydrolase Streptomyces agglomeratus
9actn-a0a1e5pyb8 Streptomyces subrutilus. Hydrolase Streptomyces subrutilus
9actn-a0a1e7jf99 Streptomyces abyssalis. Hydrolase Streptomyces abyssalis
9actn-a0a1g9x936 Streptomyces wuyuanensis. TAP-like protein Streptomyces wuyuanensis
9actn-a0a1h0vej6 Streptomyces sp. cf386. TAP-like protein Streptomyces sp. cf386
9pseu-a0a1h2u5j0 Amycolatopsis xylanica. Alpha\/beta hydrolase fold Amycolatopsis xylanica
9pseu-a0a1h3mu06 Amycolatopsis xylanica. Alpha\/beta hydrolase fold Amycolatopsis xylanica
9pseu-a0a1h3muj2 Amycolatopsis xylanica. Alpha\/beta hydrolase fold Amycolatopsis xylanica
9actn-a0a1h4umj6 Streptomyces sp. PAN_FS17. TAP-like protein Streptomyces sp. PAN_FS17
9actn-a0a1h6ew06 Nonomuraea solani. Alpha\/beta hydrolase fold Nonomuraea solani
9actn-a0a1h8d0v8 Nonomuraea pusilla. Alpha\/beta hydrolase fold Nonomuraea pusilla
9actn-a0a1i5x2l9 Actinomadura madurae. Alpha\/beta hydrolase fold Actinomadura madurae
9delt-a0a1l9awu5 Cystobacter ferrugineus. Transporter Cystobacter ferrugineus
9actn-a0a1n7h5k2 Microbispora rosea. TAP-like protein Microbispora rosea
9actn-a0a1p8xw91 Streptomyces autolyticus. Alpha\/beta hydrolase Streptomyces autolyticus
9actn-a0a1q4v6n8 Streptomyces uncialis. Hydrolase Streptomyces uncialis
strun-Ucmk1 Streptomyces uncialis. AB hydrolase-1 domain-containing protein Streptomyces uncialis
9actn-a0a1q4v846 Streptomyces uncialis. Hydrolase Streptomyces uncialis
9actn-a0a1q4v9j8 Streptomyces uncialis. Hydrolase Streptomyces uncialis
9actn-a0a1q4vdi5 Streptomyces uncialis. Hydrolase Streptomyces uncialis
9actn-a0a1q4w6n9 Streptomyces sp. CB02056. Hydrolase Streptomyces sp. CB02056
9actn-a0a1q4yc91 Streptomyces sp. TSRI0281. Hydrolase Streptomyces sp. TSRI0281
9actn-a0a1q4yun2 Streptomyces sp. TSRI0281. Hydrolase Streptomyces sp. TSRI0281
9actn-a0a1q5g588 Streptomyces sp. CB01580. Hydrolase Streptomyces sp. CB01580
9actn-a0a1q5h571 Streptomyces sp. CB01580. Hydrolase Streptomyces sp. CB01580
9actn-a0a1q5kh06 Streptomyces sp. CB01883. Hydrolase Streptomyces sp. CB01883
9actn-a0a1q5lnf3 Streptomyces sp. CB03234. Hydrolase Streptomyces sp. CB03234
9actn-a0a1q5n7d1 Streptomyces sp. CB00455. Hydrolase Streptomyces sp. CB00455
9pseu-a0a1q9ljt9 Actinokineospora bangkokensis. Hydrolase Actinokineospora bangkokensis
9pseu-a0a1q9ulv9 Saccharomonospora sp. CUA-673. Hydrolase Saccharomonospora sp. CUA-673
9actn-a0a1s1qli0 Frankia sp. EUN1h. Alpha\/beta hydrolase Frankia sp. EUN1h
9actn-a0a1s2pg03 Streptomyces colonosanans. Alpha\/beta hydrolase Streptomyces colonosanans
9actn-a0a1s2q930 Streptomyces monashensis. Alpha\/beta hydrolase Streptomyces monashensis
9actn-a0a1t3nk49 Embleya scabrispora. Alpha\/beta hydrolase Embleya scabrispora
9actn-a0a1v4a903 Streptomyces tsukubensis. Alpha\/beta hydrolase Streptomyces tsukubensis
kibar-a0a1w2fmt4 Kibdelosporangium aridum. Alpha\/beta hydrolase fold Kibdelosporangium aridum
9actn-a0a1z1wad9 Streptomyces alboflavus. Hydrolase Streptomyces alboflavus
9actn-a0a1z2kxb2 Streptomyces albireticuli. Hydrolase Streptomyces albireticuli
9actn-a0a243rqz8 Streptomyces swartbergensis. Alpha\/beta hydrolase Streptomyces swartbergensis
9actn-a0a286e0m2 Streptomyces zhaozhouensis. TAP-like protein Streptomyces zhaozhouensis
9actn-a0a291qjb5 Streptomyces formicae. Putative exported protease Streptomyces formicae
9actn-a0a291qme0 Streptomyces formicae. Putative exported protease Streptomyces formicae
9actn-a0a291w4s4 Streptomyces alboflavus. Putative Tripeptidyl aminopeptidase Streptomyces alboflavus
9actn-a0a2c9zmw6 Streptomyces swartbergensis. Alpha\/beta hydrolase Streptomyces swartbergensis
9actn-a0a2g9dzt5 Streptomyces sp. JV178. Alpha\/beta hydrolase Streptomyces sp. JV178
9actn-a0a2h5b973 Kitasatospora sp. MMS16-BH015. Hydrolase Kitasatospora sp. MMS16-BH015
strla-a0a2k8pbx6 Streptomyces lavendulae subsp. lavendulae. Tripeptidyl aminopeptidase Streptomyces lavendulae subsp. lavendulae
9actn-a0a2p2gqg7 Streptomyces showdoensis. Hydrolase Streptomyces showdoensis
9actn-a0a2p4uq66 Actinomadura rubteroloni. Tripeptidyl aminopeptidase Actinomadura rubteroloni
9actn-DynA4 Micromonospora chersina\; Micromonospora sp. MH33. Tripeptidyl aminopeptidase DynA4 Micromonospora chersina
9actn-a0a2s1sta8 Streptomyces tirandamycinicus. Alpha\/beta hydrolase Streptomyces tirandamycinicus
9pseu-a0a2s6gmr9 Actinokineospora auranticolor. Alpha\/beta hydrolase family protein Actinokineospora auranticolor
9actn-a0a2u2zku5 Streptomyces sp. Act143. Alpha\/beta hydrolase Streptomyces sp. Act143
9actn-a0a2w2f2p9 Nonomuraea aridisoli. Alpha\/beta hydrolase Nonomuraea aridisoli
9actn-a0a2w2i222 Spongiactinospora gelatinilytica. Alpha\/beta hydrolase Spongiactinospora gelatinilytica
9actn-a0a2w2jlq1 Streptomyces sp. NTH33. Alpha\/beta hydrolase Streptomyces sp. NTH33
9actn-a0a2z4v7t6 Streptomyces sp. ICC1. Alpha\/beta hydrolase Streptomyces sp. ICC1
9pseu-a0a344l4x5 Amycolatopsis albispora. Hydrolase Amycolatopsis albispora
9pseu-a0a344l7z4 Amycolatopsis albispora. AB hydrolase-1 domain-containing protein Amycolatopsis albispora
9pseu-a0a344ljv5 Amycolatopsis albispora. AB hydrolase-1 domain-containing protein Amycolatopsis albispora
9actn-a0a344tzg1 Streptomyces globosus. Alpha\/beta hydrolase Streptomyces globosus
9actn-a0a370b5a3 Streptomyces corynorhini. Alpha\/beta hydrolase Streptomyces corynorhini
9noca-a0a370hz10 Nocardia pseudobrasiliensis. TAP-like protein Nocardia pseudobrasiliensis
9noca-a0a370i147 Nocardia pseudobrasiliensis. Alpha\/beta hydrolase family protein Nocardia pseudobrasiliensis
9actn-a0a371pqm2 Streptomyces inhibens. Alpha\/beta fold hydrolase Streptomyces inhibens
9actn-a0a371puy0 Streptomyces inhibens. Alpha\/beta hydrolase Streptomyces inhibens
9actn-a0a371pxl9 Streptomyces inhibens. Alpha\/beta hydrolase Streptomyces inhibens
9actn-a0a372gf89 Actinomadura sp. LHW52907. Alpha\/beta hydrolase Actinomadura sp. LHW52907
9actn-a0a372jcb2 Actinomadura logoneensis. Alpha\/beta hydrolase Actinomadura logoneensis
9noca-a0a3a4ju86 Nocardia panacis. Alpha\/beta fold hydrolase Nocardia panacis
9actn-a0a3e2ykr0 Micromonospora sp. MW-13. Tripeptidyl aminopeptidase Micromonospora sp. MW-13
9actn-a0a3m0hue9 Streptomyces shenzhenensis. Hydrolase Streptomyces shenzhenensis
9actn-a0a3n1czw5 Actinocorallia herbida. Alpha\/beta hydrolase family protein Actinocorallia herbida
9actn-a0a3n5a0f8 Streptomyces sp. TLI_185. TAP-like protein Streptomyces sp. TLI_185
9actn-a0a3n5bkf2 Streptomyces sp. Ag109_G2-6. TAP-like protein Streptomyces sp. Ag109_G2-6
9actn-a0a3n6ews0 Streptomyces sp. ADI96-02. Tripeptidyl aminopeptidase Streptomyces sp. ADI96-02
9actn-a0a3n6fd75 Streptomyces sp. ADI93-02. Tripeptidyl aminopeptidase Streptomyces sp. ADI93-02
9actn-a0a3n6geu6 Streptomyces sp. ADI97-07. Tripeptidyl aminopeptidase Streptomyces sp. ADI97-07
strlt-LutK2 Streptomyces luteoverticillatus (Streptoverticillium luteoverticillatus). Alpha\/beta fold hydrolase LutK2 Streptomyces luteoverticillatus
9actn-a0a3r9uv91 Streptomyces sp. WAC06614. Alpha\/beta hydrolase Streptomyces sp. WAC06614
9actn-a0a3r9wap3 Streptomyces sp. WAC06614. Alpha\/beta hydrolase Streptomyces sp. WAC06614
strlt-LutK1 Streptomyces luteoverticillatus (Streptoverticillium luteoverticillatus). Alpha\/beta fold hydrolase LutK1 Streptomyces luteoverticillatus
9actn-a0a429a7c1 Nonomuraea sp. WAC 01424. Alpha\/beta hydrolase Nonomuraea sp. WAC 01424
9actn-a0a429b7z5 Nonomuraea sp. WAC 01424. Alpha\/beta hydrolase Nonomuraea sp. WAC 01424
9actn-a0a429bst3 Nonomuraea sp. WAC 01424. Alpha\/beta hydrolase Nonomuraea sp. WAC 01424
9actn-a0a429re93 Streptomyces sp. WAC01280. Alpha\/beta hydrolase Streptomyces sp. WAC01280
9actn-a0a429rze9 Streptomyces sp. WAC06614. Alpha\/beta hydrolase Streptomyces sp. WAC06614
9actn-a0a429ued7 Streptomyces sp. WAC04770. Alpha\/beta hydrolase Streptomyces sp. WAC04770
strne-a0a445nfa3 Streptomyces netropsis (Streptoverticillium netropsis). Tripeptidyl aminopeptidase Streptomyces netropsis
9actn-a0a494v822 Streptomyces fungicidicus. Hydrolase Streptomyces fungicidicus
9pseu-a0a495vxd6 Saccharothrix australiensis. Alpha\/beta hydrolase family protein Saccharothrix australiensis
9actn-a0a498dqz6 Streptomyces sp. Z26. Alpha\/beta hydrolase Streptomyces sp. Z26
9pseu-a0a4q7j5g4 Amycolatopsis suaedae. Alpha\/beta hydrolase Amycolatopsis suaedae
9pseu-a0a4q7l4w6 Herbihabitans rhizosphaerae. TAP-like protein Herbihabitans rhizosphaerae
strka-a0a4q9hpv5 Streptomyces kasugaensis. Alpha\/beta hydrolase Streptomyces kasugaensis
9actn-a0a4r1dkr0 Streptomyces sp. KM273126. Alpha\/beta hydrolase Streptomyces sp. KM273126
9pseu-a0a4r2j744 Actinocrispum wychmicini. Pimeloyl-ACP methyl ester carboxylesterase Actinocrispum wychmicini
9actn-a0a4r4tuy2 Streptomyces hainanensis. Alpha\/beta hydrolase Streptomyces hainanensis
9actn-a0a4r4twl3 Streptomyces hainanensis. Alpha\/beta hydrolase Streptomyces hainanensis
9actn-a0a4s2teb7 Streptomyces sp. A1136. Alpha\/beta hydrolase Streptomyces sp. A1136
strst-a0a516rf07 Streptomyces spectabilis. Alpha\/beta hydrolase Streptomyces spectabilis
strst-a0a516rjy6 Streptomyces spectabilis. Alpha\/beta hydrolase Streptomyces spectabilis
strst-a0a516rkv9 Streptomyces spectabilis. Alpha\/beta hydrolase Streptomyces spectabilis
9actn-a0a540w0w2 Kitasatospora acidiphila. Alpha\/beta hydrolase Kitasatospora acidiphila
9actn-a0a561up83 Kitasatospora viridis. TAP-like protein Kitasatospora viridis
nonsp-NonK2 Nonomuraea sp. C10. Alpha\/beta hydrolase NonK2 Nonomuraea sp. C10
nonsp-NonK1 Nonomuraea sp. C10. Alpha\/beta hydrolase Nonomuraea sp. C10
9actn-a0a5d0nut6 Actinomadura chibensis. Alpha\/beta hydrolase Actinomadura chibensis
strad-a0a5j6hqe5 Streptomyces alboniger. Alpha\/beta hydrolase Streptomyces alboniger
9actn-a0a5r9mas1 Streptomyces sp. So13.3. Alpha\/beta hydrolase Streptomyces sp. So13.3
9actn-a0a5s4gzr9 Nonomuraea zeae. Alpha\/beta hydrolase Nonomuraea zeae
strju-a0a646kds0 Streptomyces jumonjinensis. Alpha\/beta hydrolase Streptomyces jumonjinensis
strju-a0a646kja6 Streptomyces jumonjinensis. Alpha\/beta hydrolase Streptomyces jumonjinensis
9actn-a0a652k8z0 Streptomyces sp. adm13(2018). Alpha\/beta hydrolase Streptomyces sp. adm13(2018)
9pseu-a0a6b2dyi3 Amycolatopsis sp. SID8362. Alpha\/beta hydrolase Amycolatopsis sp. SID8362
9actn-a0a6b2snt8 Streptomyces sp. SID10115. Alpha\/beta hydrolase Streptomyces sp. SID10115
9actn-a0a6b2xan5 Streptomyces sp. SID13726. Alpha\/beta hydrolase Streptomyces sp. SID13726
9actn-a0a6b3g2x5 Streptomyces sp. SID7982. Alpha\/beta hydrolase Streptomyces sp. SID7982
9actn-a0a6b3g971 Streptomyces sp. SID7982. Alpha\/beta hydrolase Streptomyces sp. SID7982
9actn-a0a6b3hsr7 Streptomyces sp. SID8455. Alpha\/beta hydrolase Streptomyces sp. SID8455
9actn-a0a6f8xn84 Phytohabitans flavus. Alpha\/beta hydrolase Phytohabitans flavus
9actn-a0a6h0cnf2 Streptomyces sp. DSM 40868. Alpha\/beta hydrolase Streptomyces sp. DSM 40868
9actn-a0a6h0czh6 Streptomyces sp. DSM 40868. Alpha\/beta hydrolase Streptomyces sp. DSM 40868
9actn-a0a6h9v780 Streptomyces luteolifulvus. Alpha\/beta hydrolase Streptomyces luteolifulvus
9actn-a0a6h9yr37 Actinomadura rudentiformis. Alpha\/beta fold hydrolase Actinomadura rudentiformis
9actn-a0a6i4pr03 Actinomadura sp. J1-007. Alpha\/beta fold hydrolase Actinomadura sp. J1-007
9actn-a0a6n2hw43 Streptomyces sp. sk2.1. Alpha\/beta fold hydrolase Streptomyces sp. sk2.1
strt9-a0a7g3u7a3 Streptomyces tsukubensis (strain DSM 42081 \/ NBRC 108919 \/ NRRL 18488 \/ 9993). Alpha\/beta hydrolase Streptomyces tsukubensis
strt9-a0a7g3uf98 Streptomyces tsukubensis (strain DSM 42081 \/ NBRC 108919 \/ NRRL 18488 \/ 9993). Alpha\/beta hydrolase Streptomyces tsukubensis
strt9-a0a7g3ufb8 Streptomyces tsukubensis (strain DSM 42081 \/ NBRC 108919 \/ NRRL 18488 \/ 9993). Alpha\/beta hydrolase Streptomyces tsukubensis
9actn-a0a7h8j2p6 Streptomyces sp. NA02950. Alpha\/beta fold hydrolase Streptomyces sp. NA02950
9actn-a0a7h8n9y8 Streptomyces buecherae. Alpha\/beta fold hydrolase Streptomyces buecherae
9actn-a0a7k0bx11 Actinomadura macrotermitis. Tripeptidyl aminopeptidase Actinomadura macrotermitis
9noca-a0a7k0d013 Nocardia macrotermitis. Tripeptidyl aminopeptidase Nocardia macrotermitis
9actn-a0a7k1ksi9 Actinomadura litoris. Alpha\/beta fold hydrolase Actinomadura litoris
9actn-a0a7k2qp72 Streptomyces sp. SID7760. Alpha\/beta fold hydrolase Streptomyces sp. SID7760
9actn-a0a7k2xc29 Streptomyces sp. SID2131. Alpha\/beta fold hydrolase Streptomyces sp. SID2131
9actn-a0a7k2zeb5 Streptomyces sp. SID2119. Alpha\/beta fold hydrolase Streptomyces sp. SID2119
9actn-a0a7k2znz3 Streptomyces sp. SID2119. Alpha\/beta fold hydrolase Streptomyces sp. SID2119
9actn-a0a7m2sd79 Streptomyces ferrugineus. Alpha\/beta fold hydrolase Streptomyces ferrugineus
9actn-a0a7m2sqa9 Streptomyces ferrugineus. Alpha\/beta fold hydrolase Streptomyces ferrugineus
actnm-a0a7w3lxp6 Actinomadura namibiensis. Pimeloyl-ACP methyl ester carboxylesterase Actinomadura namibiensis
9actn-a0a7w3r6d3 Thermomonospora cellulosilytica. Pimeloyl-ACP methyl ester carboxylesterase Thermomonospora cellulosilytica
9pseu-a0a7w7c6e0 Crossiella cryophila. Pimeloyl-ACP methyl ester carboxylesterase Crossiella cryophila
9pseu-a0a7w7c9p5 Crossiella cryophila. Pimeloyl-ACP methyl ester carboxylesterase Crossiella cryophila
9actn-a0a7w7plv4 Streptomyces olivoverticillatus. Pimeloyl-ACP methyl ester carboxylesterase Streptomyces olivoverticillatus
9actn-a0a7w8eig5 Nonomuraea endophytica. Pimeloyl-ACP methyl ester carboxylesterase Nonomuraea endophytica
9actn-a0a7w9mke9 Streptosporangium becharense. Pimeloyl-ACP methyl ester carboxylesterase Streptosporangium becharense
9actn-a0a7w9q9w3 Streptomyces zagrosensis. Pimeloyl-ACP methyl ester carboxylesterase Streptomyces zagrosensis
9actn-a0a7w9qeb0 Streptomyces zagrosensis. Pimeloyl-ACP methyl ester carboxylesterase Streptomyces zagrosensis
9actn-a0a7x0heg5 Streptomyces candidus. Pimeloyl-ACP methyl ester carboxylesterase Streptomyces candidus
9actn-a0a7x0iez5 Sphaerisporangium rubeum. Pimeloyl-ACP methyl ester carboxylesterase Sphaerisporangium rubeum
9actn-a0a7y0g1x4 Streptomyces sp. R302. Alpha\/beta hydrolase Streptomyces sp. R302
9actn-a0a7y6id81 Nonomuraea montanisoli. Alpha\/beta fold hydrolase Nonomuraea montanisoli
9actn-a0a7y6m322 Nonomuraea montanisoli. Alpha\/beta fold hydrolase Nonomuraea montanisoli
9actn-a0a7y8wz83 Streptomyces sp. BR123. Alpha\/beta fold hydrolase Streptomyces sp. BR123
9pseu-a0a840iz68 Amycolatopsis jiangsuensis. Pimeloyl-ACP methyl ester carboxylesterase Amycolatopsis jiangsuensis
9pseu-a0a840izr4 Amycolatopsis jiangsuensis. Pimeloyl-ACP methyl ester carboxylesterase Amycolatopsis jiangsuensis
9pseu-a0a840nme0 Saccharopolyspora gloriosae. Pimeloyl-ACP methyl ester carboxylesterase Saccharopolyspora gloriosae
9pseu-a0a840ntw1 Saccharopolyspora gloriosae. Pimeloyl-ACP methyl ester carboxylesterase Saccharopolyspora gloriosae
9actn-a0a840p210 Thermocatellispora tengchongensis. Pimeloyl-ACP methyl ester carboxylesterase Thermocatellispora tengchongensis
9pseu-a0a841ckv4 Saccharothrix tamanrassetensis. Pimeloyl-ACP methyl ester carboxylesterase Saccharothrix tamanrassetensis
9noca-a0a846xnn7 Nocardia speluncae. Alpha\/beta hydrolase Nocardia speluncae
9actn-a0a852v6f8 Streptosporangium sandarakinum. Pimeloyl-ACP methyl ester carboxylesterase Streptosporangium sandarakinum
9pseu-a0a8h9iwe9 Amycolatopsis bartoniae. Alpha\/beta hydrolase Amycolatopsis bartoniae
9actn-a0a8j3t5u8 Planobispora takensis. Tripeptidyl aminopeptidase Planobispora takensis
plaro-a0a8j3whv8 Planobispora rosea. Tripeptidyl aminopeptidase Planobispora rosea
9actn-a0a8j3wty5 Planobispora takensis. Alpha\/beta hydrolase Planobispora takensis
9actn-a0a8j3wxz9 Planosporangium mesophilum. Alpha\/beta hydrolase Planosporangium mesophilum
9actn-a0a8j4edz1 Virgisporangium ochraceum. Alpha\/beta hydrolase Virgisporangium ochraceum
strsw-c9yz80 Streptomyces scabiei (strain 87.22). Putative secreted hydrolase Streptomyces scabiei
strsw-c9z9q3 Streptomyces scabiei (strain 87.22). Putative secreted hydrolase Streptomyces scabiei
strsw-c9zg57 Streptomyces scabiei (strain 87.22). Putative secreted hydrolase Streptomyces scabiei
strrd-d2b1i6 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/ NI 9100). Abhydrolase_4 domain-containing protein Streptosporangium roseum
conwi-d3fc89 Conexibacter woesei (strain DSM 14684 \/ CIP 108061 \/ JCM 11494 \/ NBRC 100937 \/ ID131577). TAP domain protein Conexibacter woesei
9actn-d6k900 Streptomyces sp. e14. Secreted hydrolase Streptomyces sp. e14
9actn-d9vsp4 Streptomyces sp. C. Secreted hydrolase Streptomyces sp. C
9actn-d9wtd7 Streptomyces himastatinicus ATCC 53653. Putative secreted hydrolase Streptomyces himastatinicus ATCC 53653
strvt-d9xap6 Streptomyces viridochromogenes (strain DSM 40736 \/ JCM 4977 \/ BCRC 1201 \/ Tue 494). TAP domain-containing protein Streptomyces viridochromogenes
strcl-e2pyy1 Streptomyces clavuligerus. Putative hydrolase Streptomyces clavuligerus
strcl-e2pyy5 Streptomyces clavuligerus. Putative hydrolase Streptomyces clavuligerus
strcl-e2q7g1 Streptomyces clavuligerus. Putative hydrolase Streptomyces clavuligerus
strvp-f2r4c1 Streptomyces venezuelae (strain ATCC 10712 \/ CBS 650.69 \/ DSM 40230 \/ JCM 4526 \/ NBRC 13096 \/ PD 04745). Putative hydrolase Streptomyces venezuelae
9actn-g2glb4 Streptomyces zinciresistens K42. Hydrolase Streptomyces zinciresistens K42
strhj-h2k4a5 Streptomyces hygroscopicus subsp. jinggangensis (strain 5008). Putative peptidase Streptomyces hygroscopicus subsp. jinggangensis
saces-k0jp24 Saccharothrix espanaensis (strain ATCC 51144 \/ DSM 44229 \/ JCM 9112 \/ NBRC 15066 \/ NRRL 15764). TAP domain containing protein Saccharothrix espanaensis
saces-k0k985 Saccharothrix espanaensis (strain ATCC 51144 \/ DSM 44229 \/ JCM 9112 \/ NBRC 15066 \/ NRRL 15764). Alpha\/beta hydrolase Saccharothrix espanaensis
9actn-l1l109 Streptomyces ipomoeae 91-03. Hydrolase, alpha\/beta domain protein Streptomyces ipomoeae 91-03
9actn-l7f5u9 Streptomyces turgidiscabies Car8. Hydrolase, alpha\/beta domain protein Streptomyces turgidiscabies Car8
strmb-m2zv71 Streptomyces mobaraensis NBRC 13819 = DSM 40847. Hydrolase Streptomyces mobaraensis NBRC 13819 = DSM 40847
9actn-s3znz2 Streptomyces aurantiacus JA 4570. Putative Tripeptidyl aminopeptidase Streptomyces aurantiacus JA 4570
9actn-s4m5z1 Streptomyces afghaniensis 772. Putative Tripeptidyl aminopeptidase Streptomyces afghaniensis 772
9actn-s4m741 Streptomyces afghaniensis 772. Putative Tripeptidyl aminopeptidase Streptomyces afghaniensis 772
strc3-s5va60 Streptomyces collinus (strain DSM 40733 \/ Tue 365). Hydrolase Streptomyces collinus
nocas-u5eg51 Nocardia asteroides NBRC 15531. Putative tripeptidylaminopeptidase Nocardia asteroides NBRC 15531
nocas-u5eht1 Nocardia asteroides NBRC 15531. Putative tripeptidylaminopeptidase Nocardia asteroides NBRC 15531
9actn-u5w4l0 Actinoplanes friuliensis DSM 7358. TAP domain-containing protein Actinoplanes friuliensis DSM 7358
9actn-v4inm8 Streptomyces sp. PVA_94-07. Secreted hydrolase Streptomyces sp. PVA_94-07
9actn-v4isq3 Streptomyces sp. PVA_94-07. AB hydrolase-1 domain-containing protein Streptomyces sp. PVA_94-07
strrc-v6jgj1 Streptomyces roseochromogenus subsp. oscitans DS 12.976. Alpha\/beta hydrolase Streptomyces roseochromogenus subsp. oscitans DS 12.976
strrc-v6ks41 Streptomyces roseochromogenus subsp. oscitans DS 12.976. Hydrolase Streptomyces roseochromogenus subsp. oscitans DS 12.976
9pseu-w7ica9 Actinokineospora spheciospongiae. Secreted hydrolase Actinokineospora spheciospongiae
9pseu-w7ixg5 Actinokineospora spheciospongiae. Putative hydrolase Actinokineospora spheciospongiae
9pseu-H5.K2 Amycolatopsis vastitatis alpha\/beta fold hydrolase HS-K2 Amycolatopsis vastitatis
9pseu-H5.K1 Amycolatopsis vastitatis alpha\/beta fold hydrolase HS-K1 Amycolatopsis vastitatis

Substrate Chemical Nomenclature Proteins
Tiancimycin-B methyl (E)-3-[(1S,17S,20Z,24R,26S)-4,24-dihydroxy-6,13-dioxo-25-oxa-16-azahexacyclo[15.7.2.01,26.02,15.05,14.07,12]hexacosa-2,4,7,9,11,14,20-heptaen-18,22-diyn-26-yl]but-2-enoate strsp-TnmK2
Dabcyl-EARRGLE-edans myctu-ym24
Gly-Pro-Leu-beta-NA 1-(2-aminoacetyl)-N-[4-methyl-1-(naphthalen-2-ylamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide strco-TAP
Tiancimycin-H strsp-TnmK1
Ala-Pro-Ala-pNA (2S)-1-[(2S)-2-aminopropanoyl]-N-[(2S)-1-(4-nitroanilino)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide myctu-ym24

Inhibitor Chemical Nomenclature Proteins
Palmitate hexadecanoic acid bacan-BA4983    human-CES1    bovin-ppt    humla-1lipa    myctu-ym24    chatd-g0s652
AEBSF 4-(2-aminoethyl)benzenesulfonyl fluoride pig-dpp4    leima-OPB    halo1-d0lmj0    human-FAP    myctu-ym24

References (6)

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Gene_locus related to this paper: strsp-TnmK2

Title : Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis - Gui_2022_J.Am.Chem.Soc__
Author(s) : Gui C , Kalkreuter E , Liu YC , Adhikari A , Teijaro CN , Yang D , Chang C , Shen B
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Gene_locus related to this paper: strsp-TnmK1

Title : Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) - Naffin-Olivos_2017_Biochemistry_56_2304
Author(s) : Naffin-Olivos JL , Daab A , White A , Goldfarb NE , Milne AC , Liu D , Baikovitz J , Dunn BM , Rengarajan J , Petsko GA , Ringe D
Ref : Biochemistry , 56 :2304 , 2017
Abstract :
PubMedSearch : Naffin-Olivos_2017_Biochemistry_56_2304
PubMedID: 28346784
Gene_locus related to this paper: myctu-ym24

Title : Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2 - Naffin-Olivos_2014_PLoS.Pathog_10_e1004132
Author(s) : Naffin-Olivos JL , Georgieva M , Goldfarb N , Madan-Lala R , Dong L , Bizzell E , Valinetz E , Brandt GS , Yu S , Shabashvili DE , Ringe D , Dunn BM , Petsko GA , Rengarajan J
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PubMedSearch : Naffin-Olivos_2014_PLoS.Pathog_10_e1004132
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Gene_locus related to this paper: myctu-ym24

Title : Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation - Madan-Lala_2011_Infect.Immun_79_4828
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Abstract :
PubMedSearch : Madan-Lala_2011_Infect.Immun_79_4828
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Gene_locus related to this paper: myctu-ym24

Title : Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66 - Butler_1995_Appl.Environ.Microbiol_61_3145
Author(s) : Butler MJ , Binnie C , DiZonno MA , Krygsman P , Soltes GA , Soostmeyer G , Walczyk E , Malek LT
Ref : Applied Environmental Microbiology , 61 :3145 , 1995
Abstract :
PubMedSearch : Butler_1995_Appl.Environ.Microbiol_61_3145
PubMedID: 7487044
Gene_locus related to this paper: strco-TAP