Tiancimycin-TnmK-Tripeptidase-HIP

Relationship

Family: Tiancimycin-TnmK-Tripeptidase-HIP

Block: X

Parent Family: No family

Comment

Tnmk1 enzymes responsible for the C-C bond formation linking the anthraquinone moiety and enediyne core together in tiancimycin (TNM) biosynthesis. The anthraquinone-fused enediyne (AFE) are a class of DNA-cleaving bacterial natural products composed of a DNA-intercalating anthraquinone moiety and a 10-membered enediyne warhead. AFE are used to produce AFE-based antibody-drug conjugates. The family contains also members of other gene products included in different biosynthetic gene clusters (BGC) and polyketide synthases (PKS) including UcmK1, and DynA4. TnmK1 shares significant homology with proteases including the serine protease Hip1 (Hydrolase important for pathogenesis) from Mycobacterium tuberculosis now included in this family. All bacterial sequences. Fungi sequences might be due to horizontal transfer.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (11)

Genes Proteins in Tiancimycin-TnmK-Tripeptidase-HIP family (317)

No fragment of genes

Structures in Tiancimycin-TnmK-Tripeptidase-HIP family (11)

Substrates in Tiancimycin-TnmK-Tripeptidase-HIP family (5)

Inhibitors in Tiancimycin-TnmK-Tripeptidase-HIP family (2)

References (6)

Title : Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis - Gui_2023_Nat.Chem.Biol__
Author(s) : Gui C , Kalkreuter E , Liu YC , Li G , Steele AD , Yang D , Chang C , Shen B
Ref : Nat Chemical Biology , : , 2023
PubMedID: 37945897
Gene_locus related to this paper: strsp-TnmK2

Title : Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis - Gui_2022_J.Am.Chem.Soc__
Author(s) : Gui C , Kalkreuter E , Liu YC , Adhikari A , Teijaro CN , Yang D , Chang C , Shen B
Ref : Journal of the American Chemical Society , : , 2022
PubMedID: 36279548
Gene_locus related to this paper: strsp-TnmK1

Title : Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) - Naffin-Olivos_2017_Biochemistry_56_2304
Author(s) : Naffin-Olivos JL , Daab A , White A , Goldfarb NE , Milne AC , Liu D , Baikovitz J , Dunn BM , Rengarajan J , Petsko GA , Ringe D
Ref : Biochemistry , 56 :2304 , 2017
PubMedID: 28346784
Gene_locus related to this paper: myctu-ym24

Title : Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2 - Naffin-Olivos_2014_PLoS.Pathog_10_e1004132
Author(s) : Naffin-Olivos JL , Georgieva M , Goldfarb N , Madan-Lala R , Dong L , Bizzell E , Valinetz E , Brandt GS , Yu S , Shabashvili DE , Ringe D , Dunn BM , Petsko GA , Rengarajan J
Ref : PLoS Pathog , 10 :e1004132 , 2014
PubMedID: 24830429
Gene_locus related to this paper: myctu-ym24

Title : Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation - Madan-Lala_2011_Infect.Immun_79_4828
Author(s) : Madan-Lala R , Peixoto KV , Re F , Rengarajan J
Ref : Infect Immun , 79 :4828 , 2011
PubMedID: 21947769
Gene_locus related to this paper: myctu-ym24

Title : Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66 - Butler_1995_Appl.Environ.Microbiol_61_3145
Author(s) : Butler MJ , Binnie C , DiZonno MA , Krygsman P , Soltes GA , Soostmeyer G , Walczyk E , Malek LT
Ref : Applied Environmental Microbiology , 61 :3145 , 1995
PubMedID: 7487044
Gene_locus related to this paper: strco-TAP