9Q6I

Name : Human prolyl endopeptidase (PREP) - complex with JP-6-1-7

Revelation date : 01-Jul-2026

Family : S9N_PPCE_Peptidase_S9

Gene_locus : human-PREP

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Fucci, I.J., Thakur, K., Pandian, J., Yoo, E., Monteiro, D.C.F.

Ligand : Inhibitor JP-6-1-7 Ligand in structure: Ligplot

References (1)

Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__
Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E
Ref : Journal of Medicinal Chemistry , : , 2026
Abstract :
PubMedSearch : Thakur_2026_J.Med.Chem__
PubMedID: 41512187
Gene_locus related to this paper: human-PREPL

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 9Q6I Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 9Q6I Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 9Q6I Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 9Q6I 3D, interactive encyclopedia of proteins - PROTEOPEDIA server