human-PREP
Homo sapiens (Human) Prolyl endopeptidase PE, Post-proline cleaving enzyme PPCE, prolyl oligopeptidase POP hPOP
Comment
also dj355l5.1 PREP Q9BX53 || Belongs to peptidase family s9A
Relationship
Family : S9N_PPCE_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
Sequence
Peptide
MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS IREGCDPVNR LWYCDLQQES SGIAGILKWV KLIDNFEGEY DYVTNEGTVF TFKTNRQSPN YRVINIDFWD PEESKWKVLV PEHEKDVLEW IACVRSNFLV LCYLHDVKNI LQLHDLTTGA LLKTFPLDVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP
References (30)
| Title : Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications - Plescia_2022_Eur.J.Med.Chem_240_114543 |
| Author(s) : Plescia J , Hedou D , Pousse ME , Labarre A , Dufresne C , Mittermaier A , Moitessier N |
| Ref : Eur Journal of Medicinal Chemistry , 240 :114543 , 2022 |
| Abstract : |
| PubMedSearch : Plescia_2022_Eur.J.Med.Chem_240_114543 |
| PubMedID: 35797897 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase - Kulkarni_2021_Evid.Based.Complement.Alternat.Med_2021_6687572 |
| Author(s) : Kulkarni AM , Rampogu S , Lee KW |
| Ref : Evid Based Complement Alternat Med , 2021 :6687572 , 2021 |
| Abstract : |
| PubMedSearch : Kulkarni_2021_Evid.Based.Complement.Alternat.Med_2021_6687572 |
| PubMedID: 33897801 |
| Gene_locus related to this paper: human-PREP |
| Title : Discovery of covalent prolyl oligopeptidase boronic ester inhibitors - Plescia_2020_Eur.J.Med.Chem_185_111783 |
| Author(s) : Plescia J , Dufresne C , Janmamode N , Wahba AS , Mittermaier AK , Moitessier N |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111783 , 2020 |
| Abstract : |
| PubMedSearch : Plescia_2020_Eur.J.Med.Chem_185_111783 |
| PubMedID: 31732257 |
| Gene_locus related to this paper: human-PREP |
| Title : Computational design of substrate selective inhibition - Da'adoosh_2020_PLoS.Comput.Biol_16_e1007713 |
| Author(s) : Da'adoosh B , Kaito K , Miyashita K , Sakaguchi M , Goldblum A |
| Ref : PLoS Comput Biol , 16 :e1007713 , 2020 |
| Abstract : |
| PubMedSearch : Da'adoosh_2020_PLoS.Comput.Biol_16_e1007713 |
| PubMedID: 32196495 |
| Gene_locus related to this paper: human-PREP |
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| Abstract : |
| PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision - Takahashi_2018_Bioorg.Med.Chem.Lett_28_930 |
| Author(s) : Takahashi S , Kawano T , Nakajima N , Suda Y , Usukhbayar N , Kimura KI , Koshino H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 28 :930 , 2018 |
| Abstract : |
| PubMedSearch : Takahashi_2018_Bioorg.Med.Chem.Lett_28_930 |
| PubMedID: 29429833 |
| Gene_locus related to this paper: human-PREP |
| Title : Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics - Guardiola_2018_Cell.Chem.Biol_25_1031 |
| Author(s) : Guardiola S , Prades R , Mendieta L , Brouwer AJ , Streefkerk J , Nevola L , Tarrago T , Liskamp RMJ , Giralt E |
| Ref : Cell Chemical Biology , 25 :1031 , 2018 |
| Abstract : |
| PubMedSearch : Guardiola_2018_Cell.Chem.Biol_25_1031 |
| PubMedID: 29779956 |
| Gene_locus related to this paper: human-PREP |
| Title : The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia - Prades_2017_Eur.Neuropsychopharmacol_27_180 |
| Author(s) : Prades R , Munarriz-Cuezva E , Uriguen L , Gil-Pisa I , Gomez L , Mendieta L , Royo S , Giralt E , Tarrago T , Meana JJ |
| Ref : European Neuropsychopharmacology , 27 :180 , 2017 |
| Abstract : |
| PubMedSearch : Prades_2017_Eur.Neuropsychopharmacol_27_180 |
| PubMedID: 27986355 |
| Gene_locus related to this paper: human-PREP |
| Title : Chemical Composition and Inhibitory Effects of Hypericum brasiliense and H. connatum on Prolyl Oligopeptidase and Acetylcholinesterase Activities - Dos_2016_Med.Chem_12_457 |
| Author(s) : Dos Santos MZ , Dalcol, II , Adolpho L , Teixido M , Tarrago T , Morel A , Giralt E |
| Ref : Med Chem , 12 :457 , 2016 |
| Abstract : |
| PubMedSearch : Dos_2016_Med.Chem_12_457 |
| PubMedID: 26497127 |
| Gene_locus related to this paper: human-PREP |
| Title : 3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors - Mariaule_2016_J.Med.Chem_59_4221 |
| Author(s) : Mariaule G , De Cesco S , Airaghi F , Kurian J , Schiavini P , Rocheleau S , Huskic I , Auclair K , Mittermaier A , Moitessier N |
| Ref : Journal of Medicinal Chemistry , 59 :4221 , 2016 |
| Abstract : |
| PubMedSearch : Mariaule_2016_J.Med.Chem_59_4221 |
| PubMedID: 26619267 |
| Gene_locus related to this paper: human-PREP |
| Title : Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics - Lopez_2016_Chembiochem_17_913 |
| Author(s) : Lopez A , Herranz-Trillo F , Kotev M , Gairi M , Guallar V , Bernado P , Millet O , Tarrago T , Giralt E |
| Ref : Chembiochem , 17 :913 , 2016 |
| Abstract : |
| PubMedSearch : Lopez_2016_Chembiochem_17_913 |
| PubMedID: 26918396 |
| Gene_locus related to this paper: human-PREP |
| Title : Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques - Kotev_2015_Biophys.J_108_116 |
| Author(s) : Kotev M , Lecina D , Tarrago T , Giralt E , Guallar V |
| Ref : Biophysical Journal , 108 :116 , 2015 |
| Abstract : |
| PubMedSearch : Kotev_2015_Biophys.J_108_116 |
| PubMedID: 25564858 |
| Gene_locus related to this paper: human-PREP |
| Title : Prolyl Oligopeptidase Enhances alpha-Synuclein Dimerization via Direct Protein-Protein Interaction - Savolainen_2015_J.Biol.Chem_290_5117 |
| Author(s) : Savolainen MH , Yan X , Myohanen TT , Huttunen HJ |
| Ref : Journal of Biological Chemistry , 290 :5117 , 2015 |
| Abstract : |
| PubMedSearch : Savolainen_2015_J.Biol.Chem_290_5117 |
| PubMedID: 25555914 |
| Gene_locus related to this paper: human-PREP |
| Title : Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice - Kim_2014_Proc.Natl.Acad.Sci.U.S.A_111_11876 |
| Author(s) : Kim JD , Toda C , D'Agostino G , Zeiss CJ , DiLeone RJ , Elsworth JD , Kibbey RG , Chan O , Harvey BK , Richie CT , Savolainen M , Myohanen T , Jeong JK , Diano S |
| Ref : Proc Natl Acad Sci U S A , 111 :11876 , 2014 |
| Abstract : |
| PubMedSearch : Kim_2014_Proc.Natl.Acad.Sci.U.S.A_111_11876 |
| PubMedID: 25071172 |
| Gene_locus related to this paper: human-PREP , mouse-ppce |
| Title : Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells - Suzuki_2014_Biochem.Biophys.Res.Commun_443_91 |
| Author(s) : Suzuki K , Sakaguchi M , Tanaka S , Yoshimoto T , Takaoka M |
| Ref : Biochemical & Biophysical Research Communications , 443 :91 , 2014 |
| Abstract : |
| PubMedSearch : Suzuki_2014_Biochem.Biophys.Res.Commun_443_91 |
| PubMedID: 24269815 |
| Gene_locus related to this paper: human-PREP |
| Title : Inhibitory Effect of Verbascoside Isolated from Buddleja brasiliensis Jacq. ex Spreng on Prolyl Oligopeptidase Activity - Filho_2012_Phytother.Res_26_1472 |
| Author(s) : Filho AG , Morel AF , Adolpho L , Ilha V , Giralt E , Tarrago T , Dalcol II |
| Ref : Phytother Res , 26 :1472 , 2012 |
| Abstract : |
| PubMedSearch : Filho_2012_Phytother.Res_26_1472 |
| PubMedID: 22275311 |
| Gene_locus related to this paper: human-PREP |
| Title : Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010 - Lopez_2011_Expert.Opin.Ther.Pat_21_1023 |
| Author(s) : Lopez A , Tarrago T , Giralt E |
| Ref : Expert Opin Ther Pat , 21 :1023 , 2011 |
| Abstract : |
| PubMedSearch : Lopez_2011_Expert.Opin.Ther.Pat_21_1023 |
| PubMedID: 21539473 |
| Gene_locus related to this paper: human-PREP |
| Title : Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat - Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| Author(s) : Jalkanen AJ , Hakkarainen JJ , Lehtonen M , Venalainen T , Kaariainen TM , Jarho E , Suhonen M , Forsberg MM |
| Ref : Basic Clin Pharmacol Toxicol , 109 :443 , 2011 |
| Abstract : |
| PubMedSearch : Jalkanen_2011_Basic.Clin.Pharmacol.Toxicol_109_443 |
| PubMedID: 21707925 |
| Gene_locus related to this paper: human-PREP , ratno-RPOP |
| Title : A new side opening on prolyl oligopeptidase revealed by electron microscopy - Tarrago_2009_FEBS.Lett_583_3344 |
| Author(s) : Tarrago T , Martin-Benito J , Sabido E , Claasen B , Madurga S , Gairi M , Valpuesta JM , Giralt E |
| Ref : FEBS Letters , 583 :3344 , 2009 |
| Abstract : |
| PubMedSearch : Tarrago_2009_FEBS.Lett_583_3344 |
| PubMedID: 19782684 |
| Gene_locus related to this paper: human-PREP |
| Title : Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity - Di Daniel_2009_Mol.Cell.Neurosci_41_373 |
| Author(s) : Di Daniel E , Glover CP , Grot E , Chan MK , Sanderson TH , White JH , Ellis CL , Gallagher KT , Uney J , Thomas J , Maycox PR , Mudge AW |
| Ref : Molecular & Cellular Neurosciences , 41 :373 , 2009 |
| Abstract : |
| PubMedSearch : Di Daniel_2009_Mol.Cell.Neurosci_41_373 |
| PubMedID: 19332125 |
| Gene_locus related to this paper: human-PREP , mouse-ppce |
| Title : Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity - Myohanen_2009_J.Histochem.Cytochem_57_831 |
| Author(s) : Myohanen TT , Garcia-Horsman JA , Tenorio-Laranga J , Mannisto PT |
| Ref : Journal of Histochemistry & Cytochemistry , 57 :831 , 2009 |
| Abstract : |
| PubMedSearch : Myohanen_2009_J.Histochem.Cytochem_57_831 |
| PubMedID: 19687473 |
| Gene_locus related to this paper: human-PREP |
| Title : Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor - Tarrago_2008_Bioorg.Med.Chem_16_7516 |
| Author(s) : Tarrago T , Kichik N , Claasen B , Prades R , Teixido M , Giralt E |
| Ref : Bioorganic & Medicinal Chemistry , 16 :7516 , 2008 |
| Abstract : |
| PubMedSearch : Tarrago_2008_Bioorg.Med.Chem_16_7516 |
| PubMedID: 18650094 |
| Gene_locus related to this paper: human-PREP |
| Title : Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging - Moreno-Baylach_2008_Neurosci_156_580 |
| Author(s) : Moreno-Baylach MJ , Felipo V , Mannisto PT , Garcia-Horsman JA |
| Ref : Neuroscience , 156 :580 , 2008 |
| Abstract : |
| PubMedSearch : Moreno-Baylach_2008_Neurosci_156_580 |
| PubMedID: 18718510 |
| Gene_locus related to this paper: human-PREP |
| Title : The natural product berberine is a human prolyl oligopeptidase inhibitor - Tarrago_2007_ChemMedChem_2_354 |
| Author(s) : Tarrago T , Kichik N , Segui J , Giralt E |
| Ref : ChemMedChem , 2 :354 , 2007 |
| Abstract : |
| PubMedSearch : Tarrago_2007_ChemMedChem_2_354 |
| PubMedID: 17295371 |
| Gene_locus related to this paper: human-PREP |
| Title : Identification by 19F NMR of traditional Chinese medicinal plants possessing prolyl oligopeptidase inhibitory activity - Tarrago_2006_Chembiochem_7_827 |
| Author(s) : Tarrago T , Frutos S , Rodriguez-Mias RA , Giralt E |
| Ref : Chembiochem , 7 :827 , 2006 |
| Abstract : |
| PubMedSearch : Tarrago_2006_Chembiochem_7_827 |
| PubMedID: 16628753 |
| Gene_locus related to this paper: human-PREP |
| Title : Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP - Cavasin_2004_Hypertension_43_1140 |
| Author(s) : Cavasin MA , Rhaleb NE , Yang XP , Carretero OA |
| Ref : Hypertension , 43 :1140 , 2004 |
| Abstract : |
| PubMedSearch : Cavasin_2004_Hypertension_43_1140 |
| PubMedID: 15037553 |
| Gene_locus related to this paper: human-PREP |
| Title : Early prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH - Yamanaka_1999_Endocrinology_140_4609 |
| Author(s) : Yamanaka C , Lebrethon MC , Vandersmissen E , Gerard A , Purnelle G , Lemaitre M , Wilk S , Bourguignon JP |
| Ref : Endocrinology , 140 :4609 , 1999 |
| Abstract : |
| PubMedSearch : Yamanaka_1999_Endocrinology_140_4609 |
| PubMedID: 10499517 |
| Gene_locus related to this paper: human-PREP |
| Title : Inhibition of prolyl oligopeptidase by Fmoc-aminoacylpyrrolidine-2-nitriles - Li_1996_J.Neurochem_66_2105 |
| Author(s) : Li J , Wilk E , Wilk S |
| Ref : Journal of Neurochemistry , 66 :2105 , 1996 |
| Abstract : |
| PubMedSearch : Li_1996_J.Neurochem_66_2105 |
| PubMedID: 8780042 |
| Gene_locus related to this paper: human-PREP |
| Title : The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha\/beta hydrolase fold family - Goossens_1995_Eur.J.Biochem_233_432 |
| Author(s) : Goossens F , De Meester I , Vanhoof G , Hendriks D , Vriend G , Scharpe S |
| Ref : European Journal of Biochemistry , 233 :432 , 1995 |
| Abstract : |
| PubMedSearch : Goossens_1995_Eur.J.Biochem_233_432 |
| PubMedID: 7588785 |
| Gene_locus related to this paper: human-PREP |
| Title : Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase - Vanhoof_1994_Gene_149_363 |
| Author(s) : Vanhoof G , Goossens F , Hendriks L , De Meester I , Hendriks D , Vriend G , Van Broeckhoven C , Scharpe S |
| Ref : Gene , 149 :363 , 1994 |
| Abstract : |
| PubMedSearch : Vanhoof_1994_Gene_149_363 |
| PubMedID: 7959018 |
| Gene_locus related to this paper: human-PREP |