human-PREP
Homo sapiens (Human) Prolyl endopeptidase PE, Post-proline cleaving enzyme PPCE, prolyl oligopeptidase POP
Comment
also dj355l5.1 PREP Q9BX53 || Belongs to peptidase family s9A
Relationship
Family : S9N_PPCE_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
Sequence
Peptide
MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS IREGCDPVNR LWYCDLQQES SGIAGILKWV KLIDNFEGEY DYVTNEGTVF TFKTNRQSPN YRVINIDFWD PEESKWKVLV PEHEKDVLEW IACVRSNFLV LCYLHDVKNI LQLHDLTTGA LLKTFPLDVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP
References (9)
| Title : Discovery of covalent prolyl oligopeptidase boronic ester inhibitors - Plescia_2020_Eur.J.Med.Chem_185_111783 |
| Author(s) : Plescia J , Dufresne C , Janmamode N , Wahba AS , Mittermaier AK , Moitessier N |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111783 , 2020 |
| Abstract : |
| PubMedSearch : Plescia_2020_Eur.J.Med.Chem_185_111783 |
| PubMedID: 31732257 |
| Gene_locus related to this paper: human-PREP |
| Title : Computational design of substrate selective inhibition - Da'adoosh_2020_PLoS.Comput.Biol_16_e1007713 |
| Author(s) : Da'adoosh B , Kaito K , Miyashita K , Sakaguchi M , Goldblum A |
| Ref : PLoS Comput Biol , 16 :e1007713 , 2020 |
| Abstract : |
| PubMedSearch : Da'adoosh_2020_PLoS.Comput.Biol_16_e1007713 |
| PubMedID: 32196495 |
| Gene_locus related to this paper: human-PREP |
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| Abstract : |
| PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision - Takahashi_2018_Bioorg.Med.Chem.Lett_28_930 |
| Author(s) : Takahashi S , Kawano T , Nakajima N , Suda Y , Usukhbayar N , Kimura KI , Koshino H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 28 :930 , 2018 |
| Abstract : |
| PubMedSearch : Takahashi_2018_Bioorg.Med.Chem.Lett_28_930 |
| PubMedID: 29429833 |
| Gene_locus related to this paper: human-PREP |
| Title : Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics - Lopez_2016_Chembiochem_17_913 |
| Author(s) : Lopez A , Herranz-Trillo F , Kotev M , Gairi M , Guallar V , Bernado P , Millet O , Tarrago T , Giralt E |
| Ref : Chembiochem , 17 :913 , 2016 |
| Abstract : |
| PubMedSearch : Lopez_2016_Chembiochem_17_913 |
| PubMedID: 26918396 |
| Gene_locus related to this paper: human-PREP |
| Title : Prolyl Oligopeptidase Enhances alpha-Synuclein Dimerization via Direct Protein-Protein Interaction - Savolainen_2015_J.Biol.Chem_290_5117 |
| Author(s) : Savolainen MH , Yan X , Myohanen TT , Huttunen HJ |
| Ref : Journal of Biological Chemistry , 290 :5117 , 2015 |
| Abstract : |
| PubMedSearch : Savolainen_2015_J.Biol.Chem_290_5117 |
| PubMedID: 25555914 |
| Gene_locus related to this paper: human-PREP |
| Title : Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells - Suzuki_2014_Biochem.Biophys.Res.Commun_443_91 |
| Author(s) : Suzuki K , Sakaguchi M , Tanaka S , Yoshimoto T , Takaoka M |
| Ref : Biochemical & Biophysical Research Communications , 443 :91 , 2014 |
| Abstract : |
| PubMedSearch : Suzuki_2014_Biochem.Biophys.Res.Commun_443_91 |
| PubMedID: 24269815 |
| Gene_locus related to this paper: human-PREP |
| Title : The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha\/beta hydrolase fold family - Goossens_1995_Eur.J.Biochem_233_432 |
| Author(s) : Goossens F , De Meester I , Vanhoof G , Hendriks D , Vriend G , Scharpe S |
| Ref : European Journal of Biochemistry , 233 :432 , 1995 |
| Abstract : |
| PubMedSearch : Goossens_1995_Eur.J.Biochem_233_432 |
| PubMedID: 7588785 |
| Gene_locus related to this paper: human-PREP |
| Title : Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase - Vanhoof_1994_Gene_149_363 |
| Author(s) : Vanhoof G , Goossens F , Hendriks L , De Meester I , Hendriks D , Vriend G , Van Broeckhoven C , Scharpe S |
| Ref : Gene , 149 :363 , 1994 |
| Abstract : |
| PubMedSearch : Vanhoof_1994_Gene_149_363 |
| PubMedID: 7959018 |
| Gene_locus related to this paper: human-PREP |