human-PREP

Homo sapiens (Human) Prolyl endopeptidase PE, Post-proline cleaving enzyme PPCE, prolyl oligopeptidase POP

Comment

also dj355l5.1 PREP Q9BX53 || Belongs to peptidase family s9A

Relationship

Family : S9N_PPCE_Peptidase_S9

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Sequence

Peptide

MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS IREGCDPVNR LWYCDLQQES SGIAGILKWV KLIDNFEGEY DYVTNEGTVF TFKTNRQSPN YRVINIDFWD PEESKWKVLV PEHEKDVLEW IACVRSNFLV LCYLHDVKNI LQLHDLTTGA LLKTFPLDVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP

References (9)

Title : Discovery of covalent prolyl oligopeptidase boronic ester inhibitors - Plescia_2020_Eur.J.Med.Chem_185_111783
Author(s) : Plescia J , Dufresne C , Janmamode N , Wahba AS , Mittermaier AK , Moitessier N
Ref : Eur Journal of Medicinal Chemistry , 185 :111783 , 2020
PubMedID: 31732257
Gene_locus related to this paper: human-PREP

Title : Computational design of substrate selective inhibition - Da'adoosh_2020_PLoS.Comput.Biol_16_e1007713
Author(s) : Da'adoosh B , Kaito K , Miyashita K , Sakaguchi M , Goldblum A
Ref : PLoS Comput Biol , 16 :e1007713 , 2020
PubMedID: 32196495
Gene_locus related to this paper: human-PREP

Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154
Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM
Ref : Clinica Chimica Acta , 495 :154 , 2019
PubMedID: 30981844
Gene_locus related to this paper: human-FAP , human-PREP

Title : Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision - Takahashi_2018_Bioorg.Med.Chem.Lett_28_930
Author(s) : Takahashi S , Kawano T , Nakajima N , Suda Y , Usukhbayar N , Kimura KI , Koshino H
Ref : Bioorganic & Medicinal Chemistry Lett , 28 :930 , 2018
PubMedID: 29429833
Gene_locus related to this paper: human-PREP

Title : Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics - Lopez_2016_Chembiochem_17_913
Author(s) : Lopez A , Herranz-Trillo F , Kotev M , Gairi M , Guallar V , Bernado P , Millet O , Tarrago T , Giralt E
Ref : Chembiochem , 17 :913 , 2016
PubMedID: 26918396
Gene_locus related to this paper: human-PREP

Title : Prolyl Oligopeptidase Enhances alpha-Synuclein Dimerization via Direct Protein-Protein Interaction - Savolainen_2015_J.Biol.Chem_290_5117
Author(s) : Savolainen MH , Yan X , Myohanen TT , Huttunen HJ
Ref : Journal of Biological Chemistry , 290 :5117 , 2015
PubMedID: 25555914
Gene_locus related to this paper: human-PREP

Title : Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells - Suzuki_2014_Biochem.Biophys.Res.Commun_443_91
Author(s) : Suzuki K , Sakaguchi M , Tanaka S , Yoshimoto T , Takaoka M
Ref : Biochemical & Biophysical Research Communications , 443 :91 , 2014
PubMedID: 24269815
Gene_locus related to this paper: human-PREP

Title : The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha\/beta hydrolase fold family - Goossens_1995_Eur.J.Biochem_233_432
Author(s) : Goossens F , De Meester I , Vanhoof G , Hendriks D , Vriend G , Scharpe S
Ref : European Journal of Biochemistry , 233 :432 , 1995
PubMedID: 7588785
Gene_locus related to this paper: human-PREP

Title : Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase - Vanhoof_1994_Gene_149_363
Author(s) : Vanhoof G , Goossens F , Hendriks L , De Meester I , Hendriks D , Vriend G , Van Broeckhoven C , Scharpe S
Ref : Gene , 149 :363 , 1994
PubMedID: 7959018
Gene_locus related to this paper: human-PREP