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Structure Report for: 5YE7

NameThe crystal structure of Lp-PLA2 in complex with a novel inhibitor
Revelation date25-Jul-2018
FamilyPAF-Acetylhydrolase: there are 149 genes in this family, 35 structure(s)
Gene_locushuman-PLA2G7
PDB FileESTHER: header of PDB entry RCSB: Full entry
CommentLiu, Q.F.,, Xu, Y.C.
Reference
    Title: Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2
    Liu Q, Huang F, Yuan X, Wang K, Zou Y, Shen J, Xu Y
    Ref: Journal of Medicinal Chemistry, 60:10231, 2017 : PubMed

            

LigandInhibitor: CHEMBL4069230 Ligand in structure: Ligplot
Representative scheme of PAF-Acetylhydrolase structure and an image from PDBsum server
Databases
PDB-Sum5YE7 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5YE7 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5YE7 Structural Classification Of Protein - SCOP server
PROTEOPEDIA5ye7 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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