ChERT
Texaphyrin gadolinium undergoes enzymatic processing that reduces its solubility, promoting accumulation near sites of cholinesterase activity. ChERT produces MRI (magnetic resonance imaging) contrast changes in brain regions known to be enriched in cholinesterases
General
Type : Fluorescent Probe, Trimethylammonium, Ammonium
Chemical_Nomenclature : 2-{5-[N-3-(23,24-Diethyl-11,12-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}-5,18-dimethyl-19-(3-{5-[2-(trimethylammonio)ethoxycarbonyl]valerylamino}propyl)-24,84,154,264,274-pentaaza-1-gadolinanonacyclo[15.9.1.13,25.01,8.01,15.02,6.09,14.020,27.022,26]octacosa-2(6),3(28),4,7,9(14),10,12,15,17(27),18,20,22(26),24-tridecaen-4-yl)propylcarbamoyl]valeroxy}-1-(trimethylammonio)ethane
Canonical SMILES : C1(=CC3=C(C=C1OCCOCCOCCOC)N=CC5=NC(=CC2=NC(=C([C@@H]2CC)CC)C=C4N=C(C=N3)C(=C4CCCNC(CCCCC(OCC[N+](C)(C)C)=O)=O)C)C(=C5C)CCCNC(CCCCC(OCC[N+](C)(C)C)=O)=O)OCCOCCOCCOC.[Gd]
InChI : InChI=1S\/C70H107N9O14.Gd\/c1-13-53-54(14-2)58-46-60-56(22-20-28-72-68(81)24-16-18-26-70(83)93-32-30-79(8,9)10)52(4)64(77-60)50-74-62-48-66(91-44-42-89-40-38-87-36-34-85-12)65(90-43-41-88-39-37-86-35-33-84-11)47-61(62)73-49-63-51(3)55(59(76-63)45-57(53)75-58)21-19-27-71-67(80)23-15-17-25-69(82)92-31-29-78(5,6)7\;\/h45-50,53H,13-44H2,1-12H3\;\/p+2\/t53-\;\/m0.\/s1
InChIKey : DUCNBYWOMVZUGC-ZLXAPJAGSA-P
Other name(s) :
References (3)
| Title : A molecular probe for detecting cholinesterase activity in MRI - Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| Author(s) : Sen S , Dawson M , Thiabaud GD , Backman K , Fayer I , Das S , Whitmire E , Kung C , Barandov A , Jasanoff A |
| Ref : Proc Natl Acad Sci U S A , 122 :e2504547122 , 2025 |
| Abstract : |
| PubMedSearch : Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| PubMedID: 41060756 |
| Title : A molecular probe for detecting cholinesterase activity in MRI - Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| Author(s) : Sen S , Dawson M , Thiabaud GD , Backman K , Fayer I , Das S , Whitmire E , Kung C , Barandov A , Jasanoff A |
| Ref : Proc Natl Acad Sci U S A , 122 :e2504547122 , 2025 |
| Abstract : |
| PubMedSearch : Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| PubMedID: 41060756 |
| Title : A molecular probe for detecting cholinesterase activity in MRI - Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| Author(s) : Sen S , Dawson M , Thiabaud GD , Backman K , Fayer I , Das S , Whitmire E , Kung C , Barandov A , Jasanoff A |
| Ref : Proc Natl Acad Sci U S A , 122 :e2504547122 , 2025 |
| Abstract : |
| PubMedSearch : Sen_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2504547122 |
| PubMedID: 41060756 |