Florfenicol
A synthetic veterinary antibiotic closqe to chloramphenicol, that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture
General
Type : Antibiotic, Sulfonyl, Sulfur Compound
Chemical_Nomenclature : 2,2-dichloro-~{N}-[(1~{R},2~{S})-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Canonical SMILES : CS(=O)(=O)C1=CC=C(C=C1)C(C(CF)NC(=O)C(Cl)Cl)O
InChI : InChI=1S\/C12H14Cl2FNO4S\/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14\/h2-5,9-11,17H,6H2,1H3,(H,16,18)\/t9-,10-\/m1\/s1
InChIKey : AYIRNRDRBQJXIF-NXEZZACHSA-N
Other name(s) : Nuflor || (-)-Florfenicol || Sch-25298 || 3-fluorothiamphenicol || chloramphen || florphenicol || Sch 25298 || thiamphenicol, 3-fluoro
MW : 358.20
Formula : C12H14Cl2FNO4S
CAS_number : 73231-34-2, 76639-94-6
PubChem : 114811
UniChem : AYIRNRDRBQJXIF-NXEZZACHSA-N
Target
Structures : No structure
Families : Hormone-sensitive_lipase_like
References (3)
| Title : Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome - Kim_2019_PLoS.One_14_e0210298 |
| Author(s) : Kim SH , Kang PA , Han K , Lee SW , Rhee S |
| Ref : PLoS ONE , 14 :e0210298 , 2019 |
| Abstract : |
| PubMedSearch : Kim_2019_PLoS.One_14_e0210298 |
| PubMedID: 30645605 |
| Gene_locus related to this paper: 9bact-g3cr02 |
| Title : Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase - Tao_2012_Appl.Environ.Microbiol_78_6295 |
| Author(s) : Tao W , Lee MH , Wu J , Kim NH , Kim JC , Chung E , Hwang EC , Lee SW |
| Ref : Applied Environmental Microbiology , 78 :6295 , 2012 |
| Abstract : |
| PubMedSearch : Tao_2012_Appl.Environ.Microbiol_78_6295 |
| PubMedID: 22752166 |
| Gene_locus related to this paper: 9bact-g3cr00 , 9bact-g3cr02 |
| Title : Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase - Tao_2011_J.Microbiol.Biotechnol_21_1203 |
| Author(s) : Tao W , Lee MH , Yoon MY , Kim JC , Malhotra S , Wu J , Hwang EC , Lee SW |
| Ref : J Microbiol Biotechnol , 21 :1203 , 2011 |
| Abstract : |
| PubMedSearch : Tao_2011_J.Microbiol.Biotechnol_21_1203 |
| PubMedID: 22210605 |
| Gene_locus related to this paper: 9bact-g3cr00 , 9bact-g3cr02 |