Isosorbide-2,5-diaspirinate
General
Type : Isosorbide, Salicylic, Acetate, Benzoate, Pro-Drug, Drug
Chemical_Nomenclature : [(3S,3aR,6R,6aR)-6-(2-acetyloxybenzoyl)oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] 2-acetyloxybenzoate
Canonical SMILES : CC(=O)OC1=CC=CC=C1C(=O)OC2COC3C2OCC3OC(=O)C4=CC=CC=C4OC(=O)C
InChI : InChI=1S\/C24H22O10\/c1-13(25)31-17-9-5-3-7-15(17)23(27)33-19-11-29-22-20(12-30-21(19)22)34-24(28)16-8-4-6-10-18(16)32-14(2)26\/h3-10,19-22H,11-12H2,1-2H3\/t19-,20+,21-,22-\/m1\/s1
InChIKey : HUDBTWVKIKXIGG-CIAFKFPVSA-N
Other name(s) : ISDA || CHEMBL458299 || SCHEMBL12860815 || DTXSID601177840
MW : 470.4
Formula : C24H22O10
CAS_number : 208338-33-4
PubChem : 9890875
UniChem : HUDBTWVKIKXIGG-CIAFKFPVSA-N
Target
Structures : No structure
Families : BCHE
References (2)
| Title : Discovery of a true aspirin prodrug - Moriarty_2008_J.Med.Chem_51_7991 |
| Author(s) : Moriarty LM , Lally MN , Carolan CG , Jones M , Clancy JM , Gilmer JF |
| Ref : Journal of Medicinal Chemistry , 51 :7991 , 2008 |
| Abstract : |
| PubMedSearch : Moriarty_2008_J.Med.Chem_51_7991 |
| PubMedID: 19049433 |
| Title : Single oral dose study of two isosorbide-based aspirin prodrugs in the dog - Gilmer_2003_J.Pharm.Pharmacol_55_1351 |
| Author(s) : Gilmer JF , Murphy MA , Shannon JA , Breen CG , Ryder SA , Clancy JM |
| Ref : J Pharm Pharmacol , 55 :1351 , 2003 |
| Abstract : |
| PubMedSearch : Gilmer_2003_J.Pharm.Pharmacol_55_1351 |
| PubMedID: 14607016 |