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Drug

Compounds that are used or were used or marketed as medication. A chemical substance used to treat, cure, prevent, or diagnose a disease
Substrate Main targeted enzyme families Type Structure
TXH1033 ACHE Piperidine Pyridine Pro-Drug Carboxamide
POM-HEX ACPH_Peptidase_S9 Pro-Drug Drug tert-Butyl
POM-ERJ ACPH_Peptidase_S9 Pro-Drug Drug Propionate tert-Butyl
Epalrestat-RM-13 Not AlphaBeta Hydrolase target Pro-Drug Drug Fluorescent Probe Coumarin Chromen Thiazolidine Sulfur Compound
Epalrestat-RM-28 Not AlphaBeta Hydrolase target Pro-Drug Drug Fluorescent Probe Coumarin Chromen
KGP-25 Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Multitarget
Unecritinib Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Piperidine Pyrazole Pyridine
Ramipril Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Peptide
NT-0796 Carboxylesterase Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Indacen Pyrimidine
Candesartan-cilexetil Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-receptor blocker Benzimidazole
Fosinopril Plasmodium_subtelomeric_PST-A Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor Organophosphate
Fenofibrate Carb_B_Chordata Pro-Drug Drug Propionate
Sirpiglenastat Carb_B_Chordata Pro-Drug Drug Peptide
QA-Cbl BCHE Pro-Drug Drug Choline ester Trimethylammonium
Anordrin Carb_B_Chordata Pro-Drug Drug Propionate
Phospho-Ibuprofen Carb_B_Chordata phospho-NSAID Drug Pro-Drug
Rufinamide Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Carboxamide Triazol
Dimethyl-fumarate Carb_B_Chordata Drug Pro-Drug Not AlphaBeta Hydrolase target
Beclomethasone-dipropionate Arylacetamide_deacetylase Drug Pro-Drug Not AlphaBeta Hydrolase target Steroid Propionate Phenanthrene
Esmolol Carb_B_Chordata LYsophospholipase_carboxylesterase Not AlphaBeta Hydrolase target Drug Propionate
S-bromobenzylglutathione-dicyclopentyl-ester Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Sulfur Compound Peptide
Diltiazem Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Calcium Channel Antagonist Azepane Benzothiazepine
ADP-ribose Plant_lipase_EDS1-like Aminopurin Not AlphaBeta Hydrolase target Purine Drug Ribose
Remimazolam Carb_B_Chordata Benzodiazepin Not AlphaBeta Hydrolase target Drug Propionate Azepane
MGS0274 Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug
Tenofovir-alafenamide Carboxypeptidase_S10 Carb_B_Chordata Drug Pro-Drug Aminopurin Propionate Purine
Mirabegron BCHE Drug Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand Thiazol Sulfur Compound
Ethyl-Zaltoprofen Hormone-sensitive_lipase_like Bacterial_lip_FamI.3 Not AlphaBeta Hydrolase target Drug Pro-Drug Propionate Alkyl ester
Ethyl-Carprofen Hormone-sensitive_lipase_like Not AlphaBeta Hydrolase target Drug Pro-Drug Carbazol Propionate Alkyl ester
Ethyl-Flurbiprofen Hormone-sensitive_lipase_like Bacterial_lip_FamI.3 Canar_LipB Not AlphaBeta Hydrolase target Drug Pro-Drug Propionate Alkyl ester
Imidapril Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Imidazole
Indiplon Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Sulfur Compound Pyrimidine Pyrazole Thiophen
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Antibiotic
Rifabutin Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperidine Antibiotic
Baloxavir-marboxil Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Sulfur Compound
Abiraterone-acetate Arylacetamide_deacetylase Pro-Drug Drug Pyridine Not AlphaBeta Hydrolase target Phenanthrene
Ketoconazole Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Imidazole Dioxolane
Flupirtine Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Carbamate
Acebutolol Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target
Mycophenolate-mofetil Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Morpholine Benzofuran
Nintedanib Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine
Vixotrigine Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Pyrrolidine Carboxamide
Clofibrate Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate
Bemnifosbuvir Carboxypeptidase_S10 Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Purine
Remdesivir Carb_B_Chordata Carboxypeptidase_S10 Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Triazine
Molnupiravir Carb_B_Chordata BCHE Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Nucleoside
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Indole Carbamate Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand
CHEMBL1784957 ACHE Drug Pro-Drug Carbamate Derivative of Rivastigmine
CurDD BCHE CMBL Carb_B_Chordata Drug Pro-Drug Natural_modified
Rifampicin Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Natural Antibiotic
Prasugrel Carb_B_Chordata Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Cyclopropyl Antiplatlet
Eslicarbazepine-acetate Carb_B_Chordata Arylacetamide_deacetylase Drug Pro-Drug Benzazepin Carbamate Acetate Carboxamide Azepane
Trandolapril Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor
Probenecid-glucuronide ABHD10 Lactone Drug Not AlphaBeta Hydrolase target Glucuronide
Mycophenolic-acid-acyl-glucuronide ABHD10 Lactone Drug Not AlphaBeta Hydrolase target Glucuronoyl Benzofuran Glucuronide
Simvastatin Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Naphthalen
Selexipag Carb_B_Chordata Sulfonyl Sulfur Compound Not AlphaBeta Hydrolase target Pro-Drug Drug
Ciclesonide Carb_B_Chordata BCHE Not AlphaBeta Hydrolase target Pro-Drug Butyrate Drug
Clevidipine Not AlphaBeta Hydrolase target Pro-Drug Butyrate Drug
Iomazenil Carb_B_Chordata Benzodiazepin Not AlphaBeta Hydrolase target Drug Azepane
Vicagrel Arylacetamide_deacetylase Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Acetate Antiplatlet
2-oxo-clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyridine Acetate Antiplatlet
Benzoylecgonine BCHE Cocaine_esterase Drug Not AlphaBeta Hydrolase target Alkaloid Azabicyclo
Dipivefrin Carb_B_Chordata ACHE BCHE Drug Not AlphaBeta Hydrolase target Pro-Drug Propionate
CHR-2863 Carb_B_Chordata Drug
Homatropine Carb_B_Chordata A85-Mycolyl-transferase Not AlphaBeta Hydrolase target Drug Azabicyclo
W22-methyl-ester Bacterial_esterase Canar_LipB Benzodiazepin Not AlphaBeta Hydrolase target Drug Pro-Drug Azepane
Enalapril Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor
Quinapril Carb_B_Chordata Isoquinoline Not AlphaBeta Hydrolase target Drug Pro-Drug Angiotensin-converting enzyme inhibitor
Sacubitril Carb_B_Chordata Pro-Drug Not AlphaBeta Hydrolase target Drug Oxobutanoate
Dabigatran-etexilate Carb_B_Chordata Pro-Drug Not AlphaBeta Hydrolase target Drug Pyridine Propionate Benzimidazole
Clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Antiplatlet
Temocapril Carb_B_Chordata Not AlphaBeta Hydrolase target Pro-Drug Drug Angiotensin-converting enzyme inhibitor Azepane Thiophen
Sivelestat Carb_B_Chordata Peptide Drug Not AlphaBeta Hydrolase target Pro-Drug Sulfur Compound Sulfonamide Benzenesulfonamide
Camostat Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Pro-Drug
Dilazep Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Pro-Drug Diazepane
Delapril Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Pro-Drug Peptide
Benazepril Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Pro-Drug Benzazepin Azepane
Oxybutinin Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Pro-Drug Muscarinic antagonist Neuromuscular Nondepolarizing Agents
Methylphenidate Carb_B_Chordata Piperidine Not AlphaBeta Hydrolase target Drug
Oseltamivir Carb_B_Chordata BCHE Pro-Drug Drug Not AlphaBeta Hydrolase target
DTS-108 Carboxylesterase Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Peptide
Valgancyclovir Valacyclovir-hydrolase Purine Drug Not AlphaBeta Hydrolase target
Valacyclovir Valacyclovir-hydrolase Purine Drug Not AlphaBeta Hydrolase target Nucleoside
Remifentanil Carboxylesterase Carb_B_Chordata Drug Not AlphaBeta Hydrolase target Opioid analgesic
Atropine BCHE AlphaBeta_hydrolase Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Carbachol ACHE Drug Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Choline ester Analogue of substrate Muscarinic agonist Nicotinic agonist
NPC Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan Not AlphaBeta Hydrolase target Piperidine
Meperidine BCHE Carboxylesterase Carb_B_Chordata Piperidine Opioid analgesic Drug Not AlphaBeta Hydrolase target
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Drug Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Permethrin Carboxylesterase Carb_B_Chordata Carb_B_Arthropoda Carb_B_Bacteria Pyrethroid Insecticide Drug Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl
Irinotecan Carb_B_Chordata BCHE Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan
Isosorbide-2-aspirinate BCHE Isosorbide Salicylic Acetate Benzoate Pro-Drug Drug
Isosorbide-2,5-diaspirinate BCHE Isosorbide Salicylic Acetate Benzoate Pro-Drug Drug
Nitroaspirin BCHE Salicylic Pro-Drug
Oxybuprocaine BCHE Drug Local anesthetic Not AlphaBeta Hydrolase target
Isosorbide-2-aspirinate-5-mononitrate BCHE Isosorbide Salicylic Pro-Drug
Isosorbide-2-aspirinate-5-salicylate BCHE Carb_B_Chordata Isosorbide Salicylic Acetate Benzoate Pro-Drug
Aspirin BCHE Carb_B_Chordata Salicylic Acetate Benzoate Drug Antiplatelet
Bambuterol BCHE Pro-Drug Drug Carbamate tert-Butyl Adrenergic-Receptor-ligand
N-Methylnaloxonium Carb_B_Chordata Drug Isoquinoline
Cocaine BCHE Carb_B_Chordata Cocaine_esterase Natural Drug Alkaloid Benzoate Azabicyclo
6-monoacetylmorphine BCHE Natural Drug Isoquinoline Alkaloid
Heroin BCHE Carb_B_Chordata Natural Drug Isoquinoline Alkaloid
Methylprednisolone-acetate BCHE Acetate Steroid Phenanthrene Drug
Naproxen-Ethyl-Ester Canar_LipB 6_AlphaBeta_hydrolase Hormone-sensitive_lipase_like Profen prodrug Pro-Drug Drug Naphthalen Propionate
Naproxen 6_AlphaBeta_hydrolase Canar_LipB Lipase_3 Hormone-sensitive_lipase_like Drug Naphthalen
Naproxen-Methyl-Ester 6_AlphaBeta_hydrolase Hormone-sensitive_lipase_like Profen prodrug Pro-Drug Drug Naphthalen Propionate
Ibuprofen-Ethyl-Ester Hormone-sensitive_lipase_like Profen prodrug Pro-Drug Drug Propionate
Ketoprofen-Glycerol-Ester Canar_LipB Profen prodrug Pro-Drug Drug Propionate
Ketoprofen-Vinyl-Ester Canar_LipB Profen prodrug Pro-Drug Drug Aryl ester Propionate
Ketoprofen-Butyl-Ester Canar_LipB Profen prodrug Pro-Drug Drug Aryl ester Propionate
Ketoprofen-Ethyl-Ester CarbLipBact_1 Hormone-sensitive_lipase_like Bacterial_lip_FamI.3 Lipase_2 Canar_LipB Profen prodrug Pro-Drug Drug Alkyl ester Propionate
Procaine BCHE Carb_B_Chordata Local anesthetic Drug Not AlphaBeta Hydrolase target
Lidocaine Carboxylesterase Carb_B_Chordata Local anesthetic Drug Not AlphaBeta Hydrolase target
Capecitabine Carboxylesterase Carb_B_Chordata Drug Carbamate Pyrimidine Pro-Drug