Labrasol
Labrasol is a lipid-based self-emulsifying excipient used in the preparation of lipophilic drugs intended for oral delivery. It is mainly composed of PEG esters and glycerides with medium acyl chains, which are potential substrates for lipases. Labrasol is a non-ionic water dispersible surfactant composed of well-characterised polyethylene glycol (PEG) esters, a small glyceride fraction and free PEG PEG-8 mono and diesters, mono-, di- and triglycerides and free PEG-8. The main fatty acids are caprylic (C8) and capric (C10) acids
General
Type : complex mix, Polymer, Poly-ethylene-glycol
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Other name(s) : Labrasol || C440220
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Target
Structures : No structure
Families : Acidic_Lipase
References (2)
| Title : In vitro digestion of the self-emulsifying lipid excipient Labrasol() by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate - Fernandez_2013_Pharm.Res_30_3077 |
| Author(s) : Fernandez S , Jannin V , Chevrier S , Chavant Y , Demarne F , Carriere F |
| Ref : Pharm Res , 30 :3077 , 2013 |
| Abstract : |
| PubMedSearch : Fernandez_2013_Pharm.Res_30_3077 |
| PubMedID: 23636839 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters - Fernandez_2007_Biochim.Biophys.Acta_1771_633 |
| Author(s) : Fernandez S , Jannin V , Rodier JD , Ritter N , Mahler B , Carriere F |
| Ref : Biochimica & Biophysica Acta , 1771 :633 , 2007 |
| Abstract : |
| PubMedSearch : Fernandez_2007_Biochim.Biophys.Acta_1771_633 |
| PubMedID: 17418634 |