Acidic_Lipase

Relationship

Family: Acidic_Lipase

Block: X

Parent Family: Abhydrolase_6

Comment

This entry represents a family of eukaryotic lipases, including gastric triacylglycerol lipase (LIPF) lysosomal acid lipase (LIPA) and LIPJ, LIPK, LIPM, LIPN. Mutations in LIPA cause Wolman disease, Cholesterol Ester Storage Disease, CESD and mutation in LIPN causes Late-Onset Form of Autosomal-Recessive Congenital Ichthyosis

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (3)

Genes Proteins in Acidic_Lipase family (672)

Fragments of genes in Acidic_Lipase family (83)

Structures in Acidic_Lipase family (3)

Substrates in Acidic_Lipase family (38)

Inhibitors in Acidic_Lipase family (15)

References (20)

Title : Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis - Duta-Mare_2018_Biochim.Biophys.Acta_1863_467
Author(s) : Duta-Mare M , Sachdev V , Leopold C , Kolb D , Vujic N , Korbelius M , Hofer DC , Xia W , Huber K , Auer M , Gottschalk B , Magnes C , Graier WF , Prokesch A , Radovic B , Bogner-Strauss JG , Kratky D
Ref : Biochimica & Biophysica Acta , 1863 :467 , 2018
PubMedID: 29374543
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages - Schlager_2017_Oncotarget_8_40037
Author(s) : Schlager S , Vujic N , Korbelius M , Duta-Mare M , Dorow J , Leopold C , Rainer S , Wegscheider M , Reicher H , Ceglarek U , Sattler W , Radovic B , Kratky D
Ref : Oncotarget , 8 :40037 , 2017
PubMedID: 28402950
Gene_locus related to this paper: mouse-1llip

Title : Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice - Zhao_2017_J.Biol.Chem_292_19198
Author(s) : Zhao T , Ding X , Yan C , Du H
Ref : Journal of Biological Chemistry , 292 :19198 , 2017
PubMedID: 28924047
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover - Grumet_2016_J.Biol.Chem_291_17977
Author(s) : Grumet L , Eichmann TO , Taschler U , Zierler KA , Leopold C , Moustafa T , Radovic B , Romauch M , Yan C , Du H , Haemmerle G , Zechner R , Fickert P , Kratky D , Zimmermann R , Lass A
Ref : Journal of Biological Chemistry , 291 :17977 , 2016
PubMedID: 27354281
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-\/-) Mice - Du_2015_Am.J.Pathol_185_2379
Author(s) : Du H , Zhao T , Ding X , Yan C
Ref : American Journal of Pathology , 185 :2379 , 2015
PubMedID: 26212911
Gene_locus related to this paper: mouse-1llip

Title : Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease - Sun_2014_Mol.Genet.Metab_112_229
Author(s) : Sun Y , Xu YH , Du H , Quinn B , Liou B , Stanton L , Inskeep V , Ran H , Jakubowitz P , Grilliot N , Grabowski GA
Ref : Mol Genet Metab , 112 :229 , 2014
PubMedID: 24837159
Gene_locus related to this paper: mouse-1llip

Title : Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations - Ramirez_2011_J.Lipid.Res_52_688
Author(s) : Ramirez CM , Liu B , Aqul A , Taylor AM , Repa JJ , Turley SD , Dietschy JM
Ref : J Lipid Res , 52 :688 , 2011
PubMedID: 21289032
Gene_locus related to this paper: mouse-1llip

Title : A mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis - Israeli_2011_Am.J.Hum.Genet_88_482
Author(s) : Israeli S , Khamaysi Z , Fuchs-Telem D , Nousbeck J , Bergman R , Sarig O , Sprecher E
Ref : American Journal of Human Genetics , 88 :482 , 2011
PubMedID: 21439540
Gene_locus related to this paper: human-LIPN

Title : Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo) - Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217
Author(s) : Holmes RS , Cox LA , Vandeberg JL
Ref : Comparative Biochemistry & Physiology Part D Genomics Proteomics , 5 :217 , 2010
PubMedID: 20598663
Gene_locus related to this paper: human-LIPF , human-LIPJ , human-LIPK , human-LIPM , human-LIPN , mouse-LIPK

Title : Critical roles of lysosomal acid lipase in myelopoiesis - Qu_2010_Am.J.Pathol_176_2394
Author(s) : Qu P , Shelley WC , Yoder MC , Wu L , Du H , Yan C
Ref : American Journal of Pathology , 176 :2394 , 2010
PubMedID: 20348241
Gene_locus related to this paper: mouse-1llip

Title : Critical roles of lysosomal acid lipase in T cell development and function - Qu_2009_Am.J.Pathol_174_944
Author(s) : Qu P , Du H , Wilkes DS , Yan C
Ref : American Journal of Pathology , 174 :944 , 2009
PubMedID: 19179613
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung - Li_2007_Int.J.Exp.Pathol_88_427
Author(s) : Li Y , Qin Y , Li H , Wu R , Yan C , Du H
Ref : International Journal of Experimental Pathology , 88 :427 , 2007
PubMedID: 18039279
Gene_locus related to this paper: mouse-1llip

Title : Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice - Lian_2005_Am.J.Pathol_167_813
Author(s) : Lian X , Yan C , Qin Y , Knox L , Li T , Du H
Ref : American Journal of Pathology , 167 :813 , 2005
PubMedID: 16127159
Gene_locus related to this paper: mouse-1llip

Title : Identification and characterization of a triacylglycerol lipase in Arabidopsis homologous to mammalian acid lipases - El-Kouhen_2005_FEBS.Lett_579_6067
Author(s) : El-Kouhen K , Blangy S , Ortiz E , Gardies AM , Ferte N , Arondel V
Ref : FEBS Letters , 579 :6067 , 2005
PubMedID: 16226259
Gene_locus related to this paper: arath-At2g15230

Title : Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung - Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801
Author(s) : Lian X , Yan C , Yang L , Xu Y , Du H
Ref : American Journal of Physiology Lung Cell Mol Physiol , 286 :L801 , 2004
PubMedID: 14644759
Gene_locus related to this paper: mouse-1llip

Title : Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor - Roussel_2002_J.Biol.Chem_277_2266
Author(s) : Roussel A , Miled N , Berti-Dupuis L , Riviere M , Spinelli S , Berna P , Gruber V , Verger R , Cambillau C
Ref : Journal of Biological Chemistry , 277 :2266 , 2002
PubMedID: 11689574
Gene_locus related to this paper: canfa-1lipg

Title : Gastric lipase: crystal structure and activity - Canaan_1999_Biochim.Biophys.Acta_1441_197
Author(s) : Canaan S , Roussel A , Verger R , Cambillau C
Ref : Biochimica & Biophysica Acta , 1441 :197 , 1999
PubMedID: 10570247
Gene_locus related to this paper: human-LIPF

Title : Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest - Roussel_1999_J.Biol.Chem_274_16995
Author(s) : Roussel A , Canaan S , Egloff MP , Riviere M , Dupuis L , Verger R , Cambillau C
Ref : Journal of Biological Chemistry , 274 :16995 , 1999
PubMedID: 10358049
Gene_locus related to this paper: human-LIPF

Title : Occurrence of a mutation associated with Wolman disease in a family with cholesteryl ester storage disease - Maslen_1995_J.Inherit.Metab.Dis_18_620
Author(s) : Maslen CL , Babcock D , Illingworth DR
Ref : J Inherit Metab Dis , 18 :620 , 1995
PubMedID: 8598644

Title : Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease - Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718
Author(s) : Anderson RA , Byrum RS , Coates PM , Sando GN
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :2718 , 1994
PubMedID: 8146180
Gene_locus related to this paper: human-LIPA